Hypoglycemic and anti–hyperglycemic study of Gynura procumbens leaf extracts

Algariri, Khalid; Meng, Kuong Yow; Atangwho, Item Justin; Asmawi, Mohd Zaini; Sadikun, Amirin; Murugaiyah, Vikneswaran; Ismail, Norhyati

doi:10.1016/s2221-1691(13)60077-5

Cited by 72 publications

(57 citation statements)

References 16 publications

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“…One intriguing finding on G. procumbens , is its specificity in inducing hypoglycemic effect only in diabetic animals as it has been shown to cause a significant decrease in fasting blood glucose levels and suppression of glucose elevation during glucose tolerance test in diabetic rats but not normal rats (Zhang and Tan, 2000; Algariri et al, 2013). …”

Section: Biological Activitiesmentioning

confidence: 99%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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Gynura procumbens (Lour.) Merr. (Family Asteraceae) is a medicinal plant commonly found in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension. Based on the traditional uses of G. procumbens, it seems to possess high therapeutic potential for treatment of various diseases making it a target for pharmacological studies aiming to validate and provide scientific evidence for the traditional claims of its efficacy. Although there has been considerable progress in the research on G. procumbens, to date there is no review paper gathering the reported biological activities of G. procumbens. Hence, this review aims to provide an overview of the biological activities of G. procumbens based on reported in vitro and in vivo studies. In brief, G. procumbens has been reported to exhibit antihypertensive, cardioprotective, antihyperglycemic, fertility enhancement, anticancer, antimicrobial, antioxidant, organ protective, and antiinflammatory activity. The commercial applications of G. procumbens have also been summarized in this paper based on existing patents. The data compiled illustrate that G. procumbens is a potential natural source of compounds with various pharmacological actions which can be utilized for the development of novel therapeutic agents.

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Section: Biological Activitiesmentioning

confidence: 99%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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“…It was found that 25% ethanolic extract of Gynura procumbens gave the best result in reducing blood glucose level. It was also found that the Gynura procumbens extract mimics the metformin mechanism (Algariri et al 2013) by increasing the glucose intake in the muscle cells (Zurina et al 2010). However, its potential in fertility on diabetic subjects remains hardly known.…”

Section: Introductionmentioning

confidence: 99%

Gynura procumbens Leaf Improves Blood Glucose Level, Restores Fertility and Libido of Diabetic-Induced Male Rats

Kamaruzaman

Noor²

2017

JSM

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“…25 The ethanolic extract of the plant leaves has been found to improve glucose tolerance as well as decrease serum cholesterol, triglycerides in streptozotocin-induced diabetic and normal rats. 26,27 Lactuca indica: Latucain C (3) and Lactucaside (4) were isolated from L. indica showed significant anti-diabetic activity. 28 Stevia rebaudiana: Stevioside (5), a natural sweetener and a diterpene glycoside was isolated from S. rebaudiana (Bertoni) that had been used as an anti-hyperglycemic agent for the treatment of diabetes for decades.…”

Section: Asteraceaementioning

confidence: 99%

A Review on Anti-diabetic Plants

Qais

Jahan

Shajib

2018

Dhaka Univ. J. Pharm. Sci

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Diabetes mellitus is a common metabolic disorder whose prevalence is rapidly increasing all over the world. According to WHO, diabetes will be the seventh leading cause of death in 2030. Since long back, plants have been used to heal or combat illness and are the source of many modern medicines. In view of the above aspects, the present review provides information about the antidiabetic plants, available through literature source from various database. From the present study it is evident that most of the plants having anti-diabetic properties belong to the family Moraceae, Cucurbitaceae, Liliaceae, Anacardiaceae, Myrtaceae, Fabaceae, Solanaceae, Asteraceae and many others. The hypoglycemic activities are contained in different parts of these plants like leaf, rhizomes, fruits, bark, seeds or other parts which differ from species to species. It is also evident from this review that the mode of action and dosage of administration differs from plant to plant.

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Hypoglycemic and anti–hyperglycemic study of Gynura procumbens leaf extracts

Cited by 72 publications

References 16 publications

Gynura procumbens: An Overview of the Biological Activities

Gynura procumbens: An Overview of the Biological Activities

Gynura procumbens Leaf Improves Blood Glucose Level, Restores Fertility and Libido of Diabetic-Induced Male Rats

A Review on Anti-diabetic Plants

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