Hypoglycemic and anti-diabetic activity of ethanolic extract of Catharanthus pusillus (murray) g.don

Navitha, A.; Sheeba, D. A. Helen; Ck, Ramesh; Banu, Munira

doi:10.9790/3013-24401721

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…The World Health Organization (WHO) has also recommended the use of traditional plants for the treatment of DM, due to their effectiveness, non-toxic nature, and minimal or no side effects. These plant-based treatments are considered excellent options for oral therapy in the management of DM [ 13 ]. This research impetus led to the discovery of phytochemicals with remarkable antihyperglycemic potentials including berberine, curcumin, resveratrol, quercetin, epigallocatechin gallate (EGCG), etc.…”

Section: Introductionmentioning

confidence: 99%

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats

et al. 2023

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Our previous study uncovered potent inhibitory effects of two naphthoquinones from Impatiens balsamina, namely lawsone methyl ether (2-methoxy-1,4-naphthoquinone, LME) and lawsone (2-hydroxy-1,4-naphthoquinone), against α-glucosidase. This gave us the insight to compare the hypoglycemic and hypolipidemic effects of LME and lawsone in high-fat/high-fructose-diet- and nicotinamide-streptozotocin-induced diabetic rats for 28 days. LME and lawsone at the doses of 15, 30, and 45 mg/kg, respectively, produced a substantial and dose-dependent reduction in the levels of fasting blood glucose (FBG), HbA1c, and food/water intake while boosting the insulin levels and body weights of diabetic rats. Additionally, the levels of total cholesterol (TC), triglycerides (TGs), high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), aspartate transaminase (AST), alanine transaminase (ALT), creatinine, and blood urea nitrogen (BUN) in diabetic rats were significantly normalized by LME and lawsone, without affecting the normal rats. LME at a dose of 45 mg/kg exhibited the most potent antihyperglycemic and antihyperlipidemic effects, which were significantly comparable to glibenclamide but higher than those of lawsone. Furthermore, the toxicity evaluation indicated that both naphthoquinones were entirely safe for use in rodent models at doses ≤ 50 mg/kg. Therefore, the remarkable antihyperglycemic and antihyperlipidemic potentials of LME make it a promising option for future drug development.

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Section: Introductionmentioning

confidence: 99%

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats

et al. 2023

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“…Ethanolic extracts of C. pusillus possesses hypoglycaemic and anti-diabetic activities (Navitha, 2012). It is reported to contain good number of oncolytic alkaloids (Debjani, 1992).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of leaf and root methanolic extracts from Vinca pusilla Murr.

Ankad¹,

Pednekar²,

Pai³

et al. 2016

Plant Sci. Today

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Vinca pusilla Murr. is a traditional medicinal plant used to treat several diseases. To substantiate the traditional medicinal utility of the plant, the present study aims at screening the antimicrobial activity of methanolic extracts of leaves and roots against five Gram positive, five Gram negative bacterial and four fungal strains. The minimum inhibitory concentration (MIC) were determined by two fold dilution assay. The results indicated that, leaf and root extracts were more effective on Bacillus subtilis and Staphylococcus aureus strains (MIC < 1 mg/mL). The tested organisms were sensitive to root extract compared to leaf extract. Fungal strains were resistant than the bacterial strains to both the extracts. Thus the present study illustrates the antimicrobial potential of the plant.

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Botanical Features of Periwinkle, Catharanthus roseus

Neetu

2022

Compendium of Plant Genomes

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Hypoglycemic and anti-diabetic activity of ethanolic extract of Catharanthus pusillus (murray) g.don

Cited by 3 publications

References 12 publications

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats

Antimicrobial activity of leaf and root methanolic extracts from Vinca pusilla Murr.

Botanical Features of Periwinkle, Catharanthus roseus

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