Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice

Guan, Ying; Dai, Ruitong; Deng, Yulin; Sun, Lili; Meng, Shiying; Xin, Nian

doi:10.1016/j.biopha.2018.11.094

Cited by 17 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PEPCK and G-6-Pase are two rate-limiting enzymes that regulate hepatic gluconeogenesis and accelerate the transformation of glycogen, fat, and protein into glucose. The inhibition of PEPCK and G-6-Pase expression can effectively regulate the increased blood glucose (36, 40), which is consistent with the results of our present study. Lipid peroxidation caused by hyperglycemia induces liver damage in diabetes (41).…”

Section: Discussionsupporting

confidence: 92%

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

et al. 2019

View full text Add to dashboard Cite

This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, serum levels of glycated hemoglobin A1c and glucagon, hepatic levels of phosphoenolpyruvate carboxykinase and lucose-6-phosphatasem, and increased serum levels of insulin. The effect of hypolipidemic functions were indicated by suppressed levels of total cholesterol and triglyceride, and enhanced levels of hepatic glycogen and high-density lipoprotein cholesterol. The renal protective effect of AU was confirmed by the protection in renal structures and the regulation of potential indicators of nephropathy. The anti-oxidative and anti-inflammatory effects of AU were verified by a cytokine array combined with an enzyme-linked immunosorbent assay. AU decreased the expression of protein kinase C α and β2 and phosphor-nuclear factor-κB, and enhanced the expression of catalase, nuclear respiratory factor 2 (Nrf2), manganese superoxide dismutase 2, heme oxygenase-1 and−2, heat shock protein 27 (HSP27), HSP60, and HSP70 in the kidneys of db/db mice. The results confirmed that AU's anti-diabetic and anti-nephritic effects are related to its modulation on oxidative stress.

show abstract

Section: Discussionsupporting

confidence: 92%

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The improved insulin sensitivity is achieved by either systemic sensitization of insulin or direct PPAR‐γ action on the transcription of glucose disposal genes, such as Glut‐2, which is one of the downstream target genes of PPAR‐γ. [ 90,91 ] Impaired pancreatic Glut‐2 mRNA expression by an HFD resulted in increased insulin secretion by pancreatic β‐cells in response to hyperglycemia, [ 92 ] subsequently resulting in uncorrected postprandial hyperglycemia. [ 93 ] In the present investigation, Glut‐2 gene expression in the diabetic group was suppressed in parallel with the results of several previous studies.…”

Section: Discussionmentioning

confidence: 99%

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

Gamil

Fattah

Ahmed

et al. 2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Dapagliflozin (DAPA) is used for treating type 2 diabetes, whereas lansoprazole (LPZ) is used as a traditional antiulcer drug. The present study investigated the possible antidiabetic effects of LPZ on fortified diet‐fed streptozotocin (FDF/STZ)‐induced insulin‐resistant diabetic rats. On the basis of the current results, it can be concluded that LPZ could be used as an add‐on drug along with the conventional treatment for T2D as it showed beneficial effects in the current experimental model of insulin resistance.

show abstract

“…Diabetes mellitus (DM) is a common and prevalent metabolic disorder characterized by hyperglycemia and abnormal lipid and protein. 1 It is one of the five leading causes death in the world affecting both developed and developing countries alike. It was projected that about 300 million people will have the disease by the year 2025.…”

Section: Introductionmentioning

confidence: 99%

“…7 There are many oral hypoglycemic agents for the management of type-2 diabetes currently, such as biguanides and sulfonylureas, but these synthetic agents are associated with certain adverse side effects (such as hypoglycemia, drug resistance, dropsy and weight gain) and even toxicity. 1,2 In addition, these therapeutic measures have inadequate efficacy or significant mechanism-based adverse effect when used as a combined therapy. Hence, there is need for drug that has fewer side effects and elicit less hypersensitivity with high anti-diabetic regulations.…”

Section: Introductionmentioning

confidence: 99%

Oral magnesium supplementation modulates hepatic and intestinal expression of some carbohydrate metabolizing genes in type 2 diabetic rats

Fapohunda¹,

Balogun²

2019

IJMBOA

View full text Add to dashboard Cite

Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice

Cited by 17 publications

References 23 publications

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

Oral magnesium supplementation modulates hepatic and intestinal expression of some carbohydrate metabolizing genes in type 2 diabetic rats

Contact Info

Product

Resources

About