Hypoglycemic Activity of Polypeptide-p From a Plant Source

Khanna, P. K.; Jain, Shaili; Panagariya, A.; Dixit, V. P.

doi:10.1021/np50018a002

Cited by 248 publications

(159 citation statements)

References 2 publications

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“…Karunanayeke et al [6] have reported the insulin secretogouge effect of bitter gourd. Khanna et al [27] have reported hypoglycaemic activity of polypeptide-p and Baldwa et al [24] has reported plant insulin from bitter gourd. In some of the studies, fresh aqueous extract of the fruit appears to be more effective compared to dried bitter gourd during diabetes [6,7].…”

Section: Discussionmentioning

confidence: 99%

Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats

Shetty

Kumar

Sambaiah

et al. 2005

Plant Foods Hum Nutr

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Abstract. Bitter gourd (Momordica charantia), a commonly consumed vegetable is used as an adjunct in the management of diabetes mellitus. A study was carried out to examine the effect of edible portion of bitter gourd at 10% level in the diet in streptozotocin induced diabetic rats. To evaluate the glycaemic control of bitter gourd during diabetes, diet intake, gain in body weight, water intake, urine sugar, urine volume, glomerular filtration rate and fasting blood glucose profiles were monitored. Water consumption, urine volume and urine sugar were significantly higher in diabetic controls compared to normal rats and bitter gourd feeding alleviated this rise during diabetes by about 30%. Renal hypertrophy was higher in diabetic controls and bitter gourd supplementation, partially, but effectively prevented it (38%) during diabetes. Increased glomerular filtration rate in diabetes was significantly reduced (27%) by bitter gourd. An amelioration of about 30% in fasting blood glucose was observed with bitter gourd feeding in diabetic rats. These results clearly provided experimental evidence that dried bitter gourd powder in the diet at 10% level improved diabetic status signifying its beneficial effect during diabetes.

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Section: Discussionmentioning

confidence: 99%

Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats

Shetty

Kumar

Sambaiah

et al. 2005

Plant Foods Hum Nutr

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“…The most noteworthy health benefit of bitter gourd are the hypoglycemic potential demonstrated in normal [36] and diabetic [2,7,27,31] rats as well as in human subjects with type II diabetes mellitus [21] and its hypolipidemic effect [3,15,26,29]. The mechanism for the hypoglycemic effect of bitter gourd is still unclear, although it has been shown to inhibit glucose absorption [23], promote hepatic glucose utilization [31], possess an insulin-like polypeptide [18], and even to increase the insulin-positive cell number in the pancreas [1].…”

Section: Introductionmentioning

confidence: 99%

Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)

et al. 2006

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SummaryBitter gourd (Momordica charantia L.) is a common vegetable in Asia that has been used in traditional medicine for the treatment of Diabetes. PPARs are ligand-dependent transcription factors that belong to the steroid hormone nuclear receptor family and control lipid and glucose homeostasis in the body. We previously reported that the ethyl acetate (EA) extract of bitter gourd activated peroxisome proliferator receptors (PPARs) a and c. To identify the active compound that activated PPARa, wild bitter gourd EA extract was partitioned between n-hexane and 90% methanol/10% H 2 O, and the n-hexane soluble fraction was further separated by silica gel column chromatography and finally by preparative HPLC. A transactivation assay employing a clone of CHOK1 cells stably transfected with a (UAS) 4 -tk-alkaline phosphatase reporter and a chimeric receptor of GAL4-rPPARa LBD was used to track the active component. Based on Mass, NMR, and IR spectroscopy, 9cis, 11trans, 13trans-conjugated linolenic acid (9c, 11t, 13t-CLN) was identified as a PPARa activator in wild bitter gourd. The isolated 9c, 11t, 13t-CLN rich fraction also significantly induced acyl CoA oxidase (ACO) activity in a peroxisome proliferator-responsive murine hepatoma cell line, H4IIEC3, implying that 9c, 11t, 13t-CLN was able to act on a natural PPARa signaling pathway as well. The content of 9c, 11t, 13t-CLN was estimated to be about 7.1 g/kg of our dried wild bitter gourd sample. The concentration of 9c, 11t, 13t-CLN and activation activity in the hydrolyzed EA extract of the seeds was higher than that of the flesh. The potential health benefits of 9c, 11t, 13t-CLN through the PPARa regulated mechanism are worthy to be further characterized in in vivo studies.

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“…Khanna P, Jain SC et. al [7] did Polypeptide-p isolation from the fruit and seeds of Karela and showed a potent hypoglycaemic effect when administered subcutaneously to diabetic rats. Therefore, Karela which is normal ingredient of diet possess the hypoglycaemic properties probably by utilization of plasma glucose.…”

Section: Discussionmentioning

confidence: 99%

“…The dietary modifications include alterations in energy giving nutrients and supply of sufficient vitamins and minerals. Previous studies have shown that bitter melon (Momordica charantia)( karela) [5][6][7][8], have been reported that lower the blood glucose level, improved the carbohydrate metabolism, rich in iron, bitter melon has twice the beta carotene of broccoli, twice the calcium of spinach, twice the potassium of bananas, and contains vitamins C and B 1 to 3, phosphorus and good dietary fibre. It is believed to be good for the liver and has been proven by western scientists to contain insulin like substances, possesses anti-oxidant properties, acts as an anti-tumour agent, and inhibit HIV-1 infection and are effective hypolipidemic agent in normals and diabetes mellitus.…”

mentioning

confidence: 99%

Effect of Indigenous Drug Administration (KARELA) on Different Parameters Studied Among Healthy and NIDDM Subjects: A Hospital Based Study

Gupta¹,

Srivastava²

2016

IJIMS

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Hypoglycemic Activity of Polypeptide-p From a Plant Source

Cited by 248 publications

References 2 publications

Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats

Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats

Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)

Effect of Indigenous Drug Administration (KARELA) on Different Parameters Studied Among Healthy and NIDDM Subjects: A Hospital Based Study

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