Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium

Han, Chunchao; Yuan, Jun; Wang, Yingzi; Li, Lingjun

doi:10.1016/j.jtemb.2006.06.003

Cited by 60 publications

(40 citation statements)

References 26 publications

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“…Although suggested that the hypoglycemic effects of EPS were generally lower than those of the mycelia of fruiting bodies, in the present study comparatively high hypoglycemic activity was observed with the EPS of the studied mushroom isolates. Submerged mycelia of C. comatus caused a 7.5% reduction in blood glucose level (Han et al, 2006), whereas, in the present study EPS of this species reduced blood glucose by 42.78%. As shown in Table 3, the hypoglycemic activity of the EPS of the three mushroom isolates, especially Cerrena unicolor, was higher than most reported in the literature, even if they were used as intravenously and intraperitoneally.…”

Section: Discussioncontrasting

confidence: 75%

“…Non-diabetic animals given saline as negative control (A), diabetic animals animals given saline as diabetic control (B), diabetic animals animals given Cerrena unicolor exopolysaccharide at 100 mg/kg dose (C), diabetic animals animals given Coprinus comatus exopolysaccharide at 100 mg/kg dose (D), diabetic animals animals given Lenzites betulina exopolysaccharide at 100 mg/kg dose (E). Scale bar: 125 µm comatus is a mushroom claimed to benefit glycemic control in diabetes (Han et al, 2006), but there are no previous studies of the hypoglycemic activity of the EPS of these mushrooms we studied. The hypoglycemic activity of various mushroom species is well documented in the literature (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…The hypoglycemic activities of ganoderan A and B (Hikino et al, 1985), coriolan (Ikuzawa et al, 1985), and an acidic glucuronoxylomannan (Kiho et al, 2000) have been reported. Although there are some reports on the hypoglycemic effects of mushroom exopolysaccharides (EPS) (Kim et al, 2001b(Kim et al, , 2001cYang et al, 2002;, most of these studies were carried out with the fruiting bodies (Kubo et al, 1994;Gray & Flatt, 1998;Lo et al, 2006), submerged culture biomass (Kim et al, 2001a;Han et al, 2006;Lo et al, 2006;Yang et al, 2006) or intracellular polysaccharides (Kiho et al, 1993(Kiho et al, , 1994(Kiho et al, , 1995(Kiho et al, , 1996Yuan et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Yamaç

Zeytinoğlu

Kanbak

et al. 2009

Pharmaceutical Biology

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Yamaç

Zeytinoğlu

Kanbak

et al. 2009

Pharmaceutical Biology

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“…Fruiting bodies are very unstable, easy to decompose into black liquid, reminiscent of ink. Carpophores of C. comatus are valued source of nutrients and medicinal substances showing various health properties such as: antibacterial, anti-inflammatory antitumor action, lowering the blood sugar, and triglycerides cholesterol (Liu and Zhang, 2003;Han et al, 2006Han et al, , 2008Zaidman et al, 2008;Zhou and Han, 2008;Yu et al, 2009;Sabo et al, 2010).…”

Section: Biological Materialsmentioning

confidence: 99%

Growth of Mycelium of Different Edible and Medicinal Mushrooms on Medium Supplemented with Digestate from AD Biogas Plant

Jasińska

Dawidowicz

Siwulski

et al. 2017

Not Bot Horti Agrobo

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Digestate is remaining material after anaerobic digestion (AD) of a biodegradable feedstock. The AD process produces two main products: digestate and biogas; digestate is considered as a waste; however, it found application in agriculture i.e. as a soil conditioner or cultivation substrate component. Digestate is rich in nitrogen and phosphorus and can be used as a substrate component for mycelial growth of mushrooms. Aim of the study was examination of agar media supplementation with digestate from AD of foodwaste material on mycelial growth of cultivated and medicinal mushrooms. Mycelial growth of four mushroom species was investigated: Coprinus comatus, Ganoderma lucidum, Agaricus subrufescens and Laetiporus sulphureus. First experiment investigated four mushroom species and 3 digestate-only based agar media with growing amount of digestate extract. Later fastest growing mushrooms from exp. 1, C. comatus and G. lucidum, was chosen, mycelial growth was performed on 2 digestate-only based agar media and 2 what/digestate extract based agar media. Wheat-based and manure-based agar media was used as control medium. Study confirmed positive effect of digestate from AD as an addition or main component of agar media culture for mushroom mycelium growth. The amount of digestate extract affected mycelial growth of investigated species. The best agar media was digestate-based only with 25 g of extract and wheat/digestate based (150/50 g extract). The fastest and the best growth were obtained for C. comatus. The residue from AD biogas production could have found additional application as media product for mushroom mycelia production and further as a component for mushroom cultivation substrate.

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“…Rats were orally dosed with 100 mg/kg bw, 250 mg/kg bw, 500 mg/kg bw, 1000 mg/kg bw, 2000 mg/kg bw or 3000 mg/kg bw individually. Each treated groups was closely observed at different time intervals (one hour, four hour, and intermittently for next six hours, 24 hour and 48 hours [9][10] . The study was continued further for next 21 days in order to check any delayed toxic effects on gross behavioural activities 11 .…”

Section: Toxicity Analysismentioning

confidence: 99%

Untitled

2016

IJPSR

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Recent reports show that germination process increases the hypoglycemic activity of seeds many fold, and can act in a better way for diabetes management. Despite large use of fenugreek seeds than any part of the plant for the treatment of broad range of maladies including diabetes, the anti-diabetic effects of germinated seeds have not been assessed. In the present study, the effect of 21 days oral administration of germinated fenugreek seed extracts (100mg/kg bw, 200mg/kg bw, and 300mg/kg bw) on various biochemical markers like blood, glucose, blood insulin, hepatic glycogen content and key molecular markers of insulin signalling pathway in STZ-induced diabetic rats were assessed. Compared to its respective seed extract, the aqueous sprout extracts from IL8 seed genotype showed significantly higher hypoglycemic activity against the diabetic state and the best dose was established to be 300mg/kg bw. The antidiabetic effect of sprout extracts were quite comparable to standard antidiabetic drug, Voglibiose (1mg/kg bw). The germinated seed extract normalised significantly, various dysregulated biochemical and molecular markers of insulin signalling pathway than their seeds including Akt2 and GSK-3β and GS in the diabetic rats within 21 days of experimental period. To best of our knowledge, we report for the first time that germination of fenugreek seeds increases their antdiabetic activity many fold than their respective seeds. We also demonstrated a mechanistic rationale of germinated fenugreek seeds to be used alone or as an adjuvant to current therapies for better management of diabetes.

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Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium

Cited by 60 publications

References 26 publications

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Growth of Mycelium of Different Edible and Medicinal Mushrooms on Medium Supplemented with Digestate from AD Biogas Plant

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