Hypoglycemia Requiring Ambulance Services in Patients with Type 2 Diabetes is Associated with Increased Long-Term Mortality

Parsaik, Ajay K.; Carter, Rickey E.; Myers, Lucas A.; Basu, Ananda; Kudva, Yogish C.

doi:10.4158/ep12197.or

Cited by 18 publications

(23 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, our finding related to documented hypoglycemia is consistent with existing studies suggesting an increased risk of hypoglycemia among patients using SUs [12,13] and studies suggesting an association between hypoglycemia and increased morbidity and mortality among patients with type 2 diabetes [14][15][16].…”

Section: Discussionsupporting

confidence: 91%

Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes

Rajpathak

Brodovicz

et al. 2015

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes

Rajpathak

Brodovicz

et al. 2015

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

“…This study also supplements the finding of significant long-term mortality in patients with diabetes requiring emergency care reported in a similar study from the USA 16 17. The 1-year mortality seen in this study was comparable to that reported 16 17.…”

Section: Discussionsupporting

confidence: 89%

“…Sulfonylurea-induced hospitalisation in the elderly is now increasingly recognised as a problem worldwide 14 15. A recent population-based study from a single county in the USA demonstrated significant long-term mortality in patients with type 2 diabetes who required emergency medical services for hypoglycaemia 16 17. Similar long-term mortality data are lacking in the UK.…”

Section: Introductionmentioning

confidence: 99%

Patients with diabetes requiring emergency department care for hypoglycaemia: characteristics and long-term outcomes determined from multiple data sources

Rajendran

Hodgkinson

Rayman

2015

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…The ACCORD and ADVANCE trials reported a 3 and 5% increased risk of hypoglycaemia, respectively, for each additional year of age. A history of severe hypoglycaemia is also a strong predictor of subsequent episodes: a previous emergency room visit for hypoglycaemia increases the odds of a subsequent inpatient admission for hypoglycaemia by more than ninefold [28]. Finally, as recently recognized by large meta-analyses, the form of treatment per se can be associated with different risks of hypoglycaemia, with SUs and glinides being associated with a greater risk of hypoglycaemia as compared with DPP-4 inhibitors and insulin sensitizers [44,45].…”

Section: Predictors Of Hypoglycaemiamentioning

confidence: 99%

Dipeptidyl peptidase‐4 inhibitors can minimize the hypoglycaemic burden and enhance safety in elderly people with diabetes

Avogaro

Dardano

Kreutzenberg

et al. 2014

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

The prevalence of type 2 diabetes mellitus (T2DM) among elderly people is increasing. Often associated with disabilities/comorbidities, T2DM lowers the chances of successful aging and is independently associated with frailty and an increased risk of hypoglycaemia, which can be further exacerbated by antihyperglycaemic treatment. From this perspective, the clinical management of T2DM in the elderly is challenging and requires individualization of optimum glycaemic targets depending on comorbidities, cognitive functioning and ability to recognize and self-manage the disease. The lack of solid evidence-based medicine supporting treatment guidelines for older people with diabetes further complicates the matter. Several classes of medicine for the treatment of T2DM are currently available and different drug combinations are often required to achieve individualized glycaemic goals. Many of these drugs, however, carry disadvantages such as the propensity to cause weight gain or hypoglycaemia. Dipeptidyl peptidase-4 (DPP-4) inhibitors, a recent addition to the pharmacological armamentarium, have become widely accepted in clinical practice because of their efficacy, low risk of hypoglycaemia, neutral effect on body weight, and apparently greater safety in patients with kidney failure. Although more information is needed to reach definitive conclusions, growing evidence suggests that DPP-4 inhibitors may become a valuable component in the pharmacological management of elderly people with T2DM. The present review aims to delineate the potential advantages of this pharmacological approach in the treatment of elderly people with T2DM. Keywords: comorbidities, diabetes treatment, frailty, hypoglycaemia, incretin therapy, renal impairment Date submitted 20 December 2013; date of first decision 3 February 2014; date of final acceptance 20 May 2014 IntroductionIt is well known and has been amply shown that the global population with diabetes has been growing over the past decades and that it will continue to increase even further in the near future [1]. What is less appreciated is that diabetes, particularly in the Western Hemisphere, will become a major problem in the elderly population. Life expectancy has increased in the general population as well as in those with diabetes [1]. More people with diabetes will grow older and more people will develop diabetes later in life. The result will be an increase in the prevalence of diabetes in the elderly. The number of people with diabetes aged ≥65 years is expected to double between 2010 and 2015, with the actual number rising from 55 to almost 130 million [2].Diabetes in the elderly is often associated with disabilities, and >70% of the elderly people with type 2 diabetes mellitus (T2DM) have some degree of impaired physical activity [3]. Elderly subjects, especially those with diabetes, tend to be frailer and experience weight loss, to be more prone to exhaustion, to have lower energy expenditure, slower gait speed and Correspondence to: Angelo Avogaro, MD, PhD, Department of Medi...

show abstract

Hypoglycemia Requiring Ambulance Services in Patients with Type 2 Diabetes is Associated with Increased Long-Term Mortality

Cited by 18 publications

References 19 publications

Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes

Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes

Patients with diabetes requiring emergency department care for hypoglycaemia: characteristics and long-term outcomes determined from multiple data sources

Dipeptidyl peptidase‐4 inhibitors can minimize the hypoglycaemic burden and enhance safety in elderly people with diabetes

Contact Info

Product

Resources

About