Hypoglycemia in the neonate

Cornblath, Marvin; Ichord, Rebecca

doi:10.1053/sp.2000.6364

Cited by 162 publications

(138 citation statements)

References 54 publications

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“…There was a substantial delay between these neonatal symptoms and the diagnosis (age 5.8 Ϯ 3.8 months), similar to that in previous reports (22,23). The presence of a microgenitalism may have resulted in an earlier diagnosis in boys.…”

Section: Discussionsupporting

confidence: 74%

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Huet

Jc²,

Nivelon³

et al. 1999

European Journal of Endocrinology

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Objectives: To evaluate the long-term effects of GH therapy in early diagnosed GH-deficient patients treated before 1 year of age. Study design: We studied all 59 patients (33 males) recorded by Association France-Hypophyse and treated with GH (0.50 Ϯ 0.15 IU/kg (S.D.) per week) before 1 year of age. Clinical presentation and growth parameters under GH treatment were analyzed. Results: Neonatal manifestations of hypopituitarism were frequent: hypoglycemia (n ¼ 50), jaundice (n ¼ 25) and micropenis (n ¼ 17/33). Although birth length was moderately reduced (¹0.9 Ϯ 1.4), growth retardation at diagnosis (5.8 Ϯ 3.8 months) was severe (¹3.5 Ϯ 1.9 standard deviation scores (SDS)). Fifty patients (85%) had thyrotropin and/or corticotropin deficiency. After a mean duration of GH therapy of 8.0 Ϯ 3.6 years, change in height SDS was þ3:11 Ϯ 2:06 S.D., exceeding 4 SDS in 19 patients. Only 9 patients (15%) did not reach a height of ¹2 S.D. for chronological age and 20 patients (34%) exceeded their target height. Pretreatment height SDS was independently associated with total catch-up growth. Conclusion: Conventional doses of GH allow normalization of height in patients with early GH deficiency and treatment.

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Section: Discussionsupporting

confidence: 74%

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Huet

Jc²,

Nivelon³

et al. 1999

European Journal of Endocrinology

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“…However if this cannot maintain normal glucose levels or if the baby becomes symptomatic, a bolus of 2ml/kg of 10% dextrose is given over a minute followed by dextrose infusion starting @ 8 mg/kg/hr with frequent blood sugar monitoring [7]. If blood glucose does not normalize with dextrose, a number of agents which reduce the excess insulin secretion such as glucocorticoids, glucagon and diazoxide have been employed [2].…”

Section: Discussionmentioning

confidence: 99%

Cases of Beckwith-Wiedman Syndrome

Mohan

Simalti²,

Kanitkar

2009

Medical Journal Armed Forces India

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“…Hypoglycemia has been linked to poor neuro-developmental outcome and therefore they recommended aggressive screening and treatment with continuous infusion of glucoes (Narayan et al, 2001). (Cranmer, 2009, Cornblath andIchord, 2000): Any child with documented hypoglycemia not secondary to insulin therapy should be admitted in a critical care unit for careful monitoring and diagnostic testing.…”

Section: If the Child Is Unconscious Lethargic Or Convulsingmentioning

confidence: 99%