Hypoglycemia Associated with the Administration of Angiotensin-Converting Enzyme Inhibitor in a Patient with Diabetes Mellitus.

Simple Reason for Hypoglycemia: ACE Inhibitor-induced Severe Recurrent Hypoglycemia in a Nondiabetic Patient

“…Experimental studies suggested that muscle response to insulin is increased in rats with streptozotocin-induced diabetes and in patients with noninsulin-dependent diabetes, suggesting that ACE inhibitors reduce glucose concentrations by elevating systemic kinin levels [9]. In 1997, a patient with diabetes experienced alacepril-induced hypoglycemia complicated by nephropathy, with hypoglycemia in this patient correlating with the use of ACE inhibitors and impaired kidney function [11].…”