Hypoglycemia and hypothermia induced by ethanol: Antagonism by indomethacin

Ethanol-induced hypothermia in rats is antagonized by dexamethasone

“…The results presented in Figure 1 show that ethanol treatment resulted in a dosedependent reduction in body temperature, in agreement with previous results (20,29). ANOVA revealed that dexamethasone produced a significant antagonism of the hypothermic effect of 2.…”

“…Since dexamethasone antagonized the cytokine-induced Ca 2+ increase in the brain accompanying the pyretic response in rabbits (31), we speculate that a reduction in Ca 2+ ions produced by dexamethasone may be involved in the antagonism of ethanol-induced hypothermia in the present study. Since indomethacin effectively antagonized ethanol-induced hypothermia in rats (20), another possibility is that the inhibition of prostaglandin synthesis by dexamethasone could interfere with this effect. Our findings do not permit a conclusion about the molecular mechanism by which dexamethasone blocked the hypothermic effect of ethanol.…”

“…Hypothermia induced by ethanol has been related, at least partially, to neurotransmission mediated by monoamines (3,17,18) and to cellular Ca 2+ (9,19), and may be modulated by other substances such as prostaglandins (20).…”

“…Thus, each ethanol dose group had a respective saline or dexamethasone control group. The doses of ethanol and dexamethasone were obtained from the literature and from previous experiments (20,24). Colon temperature was measured again 30, 60 and 90 min after ethanol administration.…”

Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats

“…Ethanol affects CNS function by several different mechanisms, such as the induction of primary perturbations of neural membranes, reduction of calcium influx through voltage-sensitive calcium channels (Wang et al,1991), alteration in the release of the neurotransmitters dopamine (Morikawa & Morrisett, 2010), acetylcholine (Aistrup et al,1999), norepinephrine (Shefner & Tabakoff,1985), serotonin (Tabakoff et al,1977), and alteration in neurotransmission mediated by inhibitory and excitatory amino acids (Tabakoff & Hoffman, 1991). Hypothermia induced by ethanol has been related, at least partially, to neurotransmission mediated by monoamines (French & Weiner, 1991) and to cellular Ca 2+ (Paez & Myers, 1989), and may be modulated by other substances such as PGs (Morato et al,1986).…”