Hypoglycaemic Property of Yacon (Smallanthus sonchifolius (Poepp. and Hendl.) H. Robinson): A Review

Contreras‐Puentes, Neyder; Alvíz‐Amador, Antistio

doi:10.5530/phrev.2020.14.7

Cited by 9 publications

(11 citation statements)

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“…After the first step of screening of the compounds from natural sources ( Physalis peruvianus [ 90 , 91 , 92 ], Minthostachys mollis [ 54 , 93 ], Uncaria tomentosa [ 94 ], Croton lechleri [ 76 , 95 , 96 ], Smallanthus sonchifolius [ 97 , 98 , 99 , 100 ], and Lepidium meyenii [ 101 , 102 ]), the simplified molecular-input line-entry system (SMILE) was searched and retrieved from DrugBank ( , accessed on 17 July 2021) or PubChem ( , accessed on 18 July 2021) servers. The physicochemical properties such as total molecular weight (MW), octanol/water partition coefficient (cLogP), number of H-bond acceptors (HBAs), number of H-bond donors (HBDs), and the molecular polar surface area (PSA) for each compound were calculated within the Osiris DataWarrior v05.02.01 software [ 103 ].…”

Section: Methodsmentioning

confidence: 99%

“…After the first step of screening of the compounds from natural sources (Physalis peruvianus [90][91][92], Minthostachys mollis [54,93], Uncaria tomentosa [94], Croton lechleri [76,95,96], Smallanthus sonchifolius [97][98][99][100], and Lepidium meyenii [101,102]), the simplified molecularinput line-entry system (SMILE) was searched and retrieved from DrugBank (https://go. drugbank.com, accessed on 17 July 2021) or PubChem (https://pubchem.ncbi.nlm.nih.gov, accessed on 18 July 2021) servers.…”

Section: Literature Search Strategy and Data Collectionmentioning

confidence: 99%

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In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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Background: Despite research on the molecular bases of Alzheimer’s disease (AD), effective therapies against its progression are still needed. Recent studies have shown direct links between AD progression and neurovascular dysfunction, highlighting it as a potential target for new therapeutics development. In this work, we screened and evaluated the inhibitory effect of natural compounds from native Peruvian plants against tau protein, amyloid beta, and angiotensin II type 1 receptor (AT1R) pathologic AD markers. Methods: We applied in silico analysis, such as virtual screening, molecular docking, molecular dynamics simulation (MD), and MM/GBSA estimation, to identify metabolites from Peruvian plants with inhibitory properties, and compared them to nicotinamide, telmisartan, and grapeseed extract drugs in clinical trials. Results: Our results demonstrated the increased bioactivity of three plants’ metabolites against tau protein, amyloid beta, and AT1R. The MD simulations indicated the stability of the AT1R:floribundic acid, amyloid beta:rutin, and tau:brassicasterol systems. A polypharmaceutical potential was observed for rutin due to its high affinity to AT1R, amyloid beta, and tau. The metabolite floribundic acid showed bioactivity against the AT1R and tau, and the metabolite brassicasterol showed bioactivity against the amyloid beta and tau. Conclusions: This study has identified molecules from native Peruvian plants that have the potential to bind three pathologic markers of AD.

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Section: Methodsmentioning

confidence: 99%

Section: Literature Search Strategy and Data Collectionmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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“…Senyawa 3-O-metilkuersetin dan 3,4'-di-Ometilkuersetin turut terdeteksi saat diidentifikasi menggunakan senyawa standar khusus yang ada ditempat penelitiannya (dalam hal ini tidak diungkap oleh peneliti) [10]. Asam galat, asam rosmarinat, asam ferulat, asam P kumarat, asam protokatekuat, derivatif-O-kuinon, asam enkaurenoat, smallanthaditerpenat D, 5,7dihidroksi-4'-metoksiflavonol, asam 5,7,3'trihidroksi-4'-metoksiflavonol, asam en-kaurane-3β,16,β,17,19-tertol, asam en-kaurane-16β,17,18,19-tertol, asam 4,5-di-O-kafeoilkuinat 7,4'-dihidroksi-3,5'-dimetoksiflavon, dan asam 3,5-di-O-kafeoilkuinat terdeteksi untuk senyawa sebagai antihiperglikemia [11]. Saat isolasi senyawa baru yang dilakukan khusus untuk mendeteksi senyawa antikanker pada daun yakon terdeteksi senyawa enhidrofolin, uvedafolin dan sonchifolin [12].…”

Section: Daun Yakon Dan Kandungannyaunclassified

Review: Efek Farmakologis dan Efek Toksik dari Daun Yakon (Smallanthus sonchifolius)

Elawati

Yuanita

2021

UJC

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Abstract. Daun yakon mengandung senyawa fenolik seperti golongan asam organik, flavonoid, dan sesqueterpen lakton yang memiliki banyak efek farmakologis. Daun yakon sebagai antioksidan mengikat secara langsung gugus reaktif radikal serta menghambat pembentukan enzim penyebab terbentuknya radikal. Sebagai antidiabetes daun yakon menurunkan kadar glukosa darah dan meningkatkan pembentukan insulin serta menghambat proses glikogenolisis dan glukoneogenolisis. Daun yakon sebagai antikanker menginduksi nekrosis sel kanker secara kemopreventif melalui tahap primer, sekunder, dan tersier. Sesqueterpen lakton merupakan senyawa antimikroba daun yakon penghambat pertumbuhan bakteri dan jamur. Asam klorogenat dalam daun yakon mengganggu aktivitas dan metabolisme mikroba dengan merusak membran sel. Sebagai antiinflamasi daun yakon meredam terjadinya inflamasi melalui penghambatan dan pengikatan faktor DNA transkripsi NF-kB dengan mengatur transkripsi mediator pro inflamasi. Secara in vitro dan in vivo daun yakon terbukti aman dikonsumsi dalam jangka panjang sampai batas dosis efektif yang diteliti. Terdapat pula hasil bahwa efek menyembuhkan setelah pengobatan selama 30 hari bersifat reversibel, sehingga daun yakon tidak dapat dikonsumsi dalam jangka waktu panjang. Perbedaan tersebut disebabkan banyak faktor seperti spesies dan jumlah hewan uji, cara pemberian dan pemilihan dosis sampel serta efek samping yang terjadi, teknik dan prosedur pengujian termasuk cara penanganan hewan selama percobaan dan keadaan sampel harus diperhatikan dalam proses pengujian. Kata kunci : daun yakon, senyawa fenolik, efek farmakologis, efek toksik Abstract. Yacon leaves contain phenolic compounds such as organic acids, flavonoids, and lactone sesqueterpenes which have many pharmacological effects. As an antioxidant, yacon leaves bind directly to radical reactive groups and inhibit the formation of enzymes that cause radical formation. As an antidiabetic, yacon leaves reduce blood glucose levels and increase insulin formation and inhibit the processes of glycogenolysis and gluconeogenolysis. As an anti-cancer agent, yacon leaves induce chemopreventive cancer cell necrosis through primary, secondary, and tertiary stages. Sesqueterpen lactone is an antimicrobial compound of yacon leaves that inhibits the growth of bacteria and fungi. The chlorogenic acid in yacon leaves disrupts microbial activity and metabolism by damaging cell membranes. As an anti-inflammatory, yacon leaves reduce inflammation through inhibition and binding of the transcription DNA factor NF-kB by regulating the transcription of pro-inflammatory mediators. In vitro and in vivo yacon leaves are proven to be safe for consumption in the long term until the effective dosage limit studied. There is also the result that the healing effect after 30 days of treatment is reversible, so that the yakon leaves cannot be consumed in the long term. This difference is due to many factors such as species and number of tested animals, method of administration and selection of sample doses and side effects that occur, testing techniques and procedures including how to handle animals during the experiment and the state of the sample must be considered in the testing process. Key words: yavon leaves, fenolic compound, pharmacological effects, toxic effects

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“…A la planta de yacón se le han atribuido muchas propiedades beneficiosas para el organismo, entre las cuales destacan efectos antioxidantes, antimicrobianos, hipolipidémicos, antidiabéticos e incluso anticancerígenos (4,5). El yacón tiene una Más Vita.…”

Section: Introductionunclassified

“…Las raíces y tubérculos del yacón contienen antioxidantes, fructooligosacáridos (FOS), fructosa, glucosa y sacarosa. Las aplicaciones terapéuticas del tubérculo del yacón en el aparato digestivo, se fundamentan en su alto contenido de FOS con actividad prebiótica, que mejoran el crecimiento y la actividad de la flora intestinal (5,6).…”

Section: Introductionunclassified

Propiedades beneficiosas del yacón (smallanthus sonchifolius) en la salud

Minchola-Castañeda

Tirado

Montalvo-Rodríguez

et al. 2022

Más Vita. Rev. Cienc. Salud

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Introducción: El yacón (Smallanthus sonchifolius), es una planta nativa de las zonas andinas sudamericanas y se le han atribuido muchas propiedades beneficiosas para el organismo; entre las cuales destacan efectos antioxidantes, antimicrobianos, hipolipidémicos, antidiabéticos e incluso anticancerígenos. Objetivo: Ampliar el conocimiento sobre las propiedades funcionales atribuidas al yacón; para este propósito se hará una recopilación y lectura de los estudios publicados hasta la fecha sobre el yacón y se utilizarán para validar las propiedades beneficiosas que el yacón tiene sobre la salud. Materiales y métodos: Para el presente artículo se realizó una revisión sistemática desde noviembre del 2021 hasta enero del 2022, a través de búsquedas electrónicas en bases de datos como MedLine, PubMed y SciELO. Resultados: Este trabajo empieza con una breve descripción acerca de la fitoquímica del yacón; luego desarrolla las posibles propiedades antioxidante, antiinflamatoria, prebiótica, anticancerígena, hipoglicemiante e hipolipidémica atribuidas al yacón. Conclusiones: El yacón es un alimento muy nutritivo que cada vez se vuelve más conocido entre la población debido a la divulgación de sus propiedades beneficiosas, las cuales comprenden según la literatura consultada, efectos antioxidantes, antiinflamatorios, prebióticos, anticancerígenos, hipoglicemiantes e hipolipidémicos. Se considera necesario realizar más estudios sobre este alimento para dilucidar mejor sus efectos, ya que muchos de los datos reportados hasta ahora se originan en estudios con modelos animales y muy pocos con seres humanos. SUMMARY Introduction: Yacón (Smallanthus sonchifolius), is a plant native to the South American Andean areas and many properties have been attributed beneficial to the body; including antioxidant effects, antimicrobial, hypolipidemic, antidiabetic and even anticancer. Objective: Expand knowledge about the functional properties attributed to yacon; For this purpose, a compilation and reading of the studies will be made. published to date on yacon and will be used to validate the properties beneficial that yacon has on health. Materials and methods: For the This article carried out a systematic review since November 2021 until January 2022, through electronic searches in databases such as MedLine, PubMed and SciELO. Results: This work begins with a brief description about the phytochemistry of yacon; then develop the possible antioxidant, anti-inflammatory, prebiotic, anticancer, hypoglycemic and hypolipidemic properties attributed to yacón. Conclusions: Yacon is a very nutritious food that is becoming more and more known among the population due to the disclosure of its beneficial properties, which include according to the consulted literature, antioxidant, anti-inflammatory, prebiotic, anticarcinogenic, hypoglycemic and hypolipidemic. It is considered necessary carry out more studies on this food to better elucidate its effects, since much of the data reported so far originates from model studies animals and very few with humans.

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Hypoglycaemic Property of Yacon (Smallanthus sonchifolius (Poepp. and Hendl.) H. Robinson): A Review

Cited by 9 publications

References 0 publications

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

Review: Efek Farmakologis dan Efek Toksik dari Daun Yakon (Smallanthus sonchifolius)

Propiedades beneficiosas del yacón (smallanthus sonchifolius) en la salud

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