Hypoglycaemic Potential of Mangifera indica Leaves in Rats

Abstract

Hypoglycaemic activity of 50% ethanol extract of Mangifera indica tender leaves was studied in normal and streptozotocin induced diabetic rats. In normal rats, the extract was administered only once in doses of 100, 250 and 500 mg/kg per os. The highest decrease (37.73%) in plasma glucose levels was obtained with 250 mg dose after 8 h of administration. In diabetic rats, the extract produced significant antihyperglycaemic effect within 3 days when given at 250 mg/kg/day per os for 10 days. LD 50 of the extract was above 4.64 gm/kg per os.

Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

“…Single oral administration of a dose of 250 mg/kg body weight produces a potent and strong hypoglycemic effect in type 2 rats. The obtained results are supported by the finding of other investigators (Sharma et al, 1997;Aderibigbe et al, 2001).…”

“…Experiment on normal, type 1 and type 2 diabetic model rats at different prandial states have been combined in this experimental approach, which screens materials for hypo-/antihyperglycemic activity as well as provide an approximate idea on the possible target tissue(s) involved. Mangifera indica has been reported to have hypoglycemic effect in both laboratory animals (Ojewole et al, 2005;Muruganandan et al, 2005;Perpetuo et al, 2003;Aderibigbe et al, 2001;Sharma et al, 1997) and human diabetic subjects (Mahabir et al, 1997). The purpose of this work was to evaluate the hypo-and antihyperglycemic effects of M. indica in normal and both type of diabetic model rats and to find out their possible mode(s) of antidiabetic action.…”

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

“…Ethanolic extract of the leaves of M. indica L. leaves produced a significant hypoglycemic effect at a dose of 250 mg/kg, both in normal and streptozotocin (STZ)-induced diabetic animals. The stimulation of β-cells to release insulin was thought to be part of the mechanism of action [25]. The effect of the aqueous extract of the leaves of M. indica L. leaves on blood glucose level in normoglycemic, glucose-induced hyperglycemic, and STZ-induced diabetic rats indicate that the aqueous extract of the leaves of M. indica L. possesses hypoglycemic activity.…”

Multifaceted Healthy Benefits of <em>Mangifera Indica</em> L. (Mango): The Inestimable Value of an Orchard Recently Rooted in Sicilian Rural Areas

“…Activation of AGE-RAGE axis is associated with diabetic compliances, as cardiomyopathy and nephropathy. Pulp and leaf extracts of mango produced a significant hypoglycemic effect in streptozotocin (STZ)-induced diabetic rats [25][26][27]. Furthermore, Gondi et al [28] showed that also mango peel extracts have the ability to ameliorate diabetes.…”