Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of <i>Aloe perryi</i> Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Aldayel, Tahany Saleh; Alshammari, Ghedeir M.; Omar, Ulfat M.; Grace, Mary H.; Lila, Mary Ann; Yahya, Mohammed Abdo

doi:10.1080/16583655.2020.1855859

Cited by 8 publications

(10 citation statements)

References 80 publications

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“…According to the authors, the ameliorative effect of the treatment was essentially due to bioactive compounds [ 458 ]. They are known for their hepatoprotective activities and ability to lower serum transaminases, ALP, and MDA [ 459 , 460 ], with even greater success than glimepiride [ 461 , 462 ].…”

Section: Resultsmentioning

confidence: 99%

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lahlou,

Carvalho,

Pereira

et al. 2024

Pharmaceutics

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The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic applications. In vitro studies have revealed their significant inhibition of carbohydrate-metabolizing enzymes, and certain plant co-products regulate genes involved in carbohydrate metabolism and insulin secretion. In vivo trials have demonstrated antidiabetic effects, including glycaemia regulation, insulin secretion, antioxidant activity, and lipid profile modulation. Medicinal plants in NPSE exhibit various activities beyond antidiabetic, such as antioxidant, anti-inflammatory, antibacterial, anti-cancer, and more. Chemical analyses have identified over fifty compounds like phenolic acids, flavonoids, terpenoids, and polysaccharides responsible for their efficacy against diabetes. These findings underscore the potential of NPSE medicinal plants as antidiabetic candidates, urging further research to develop effective plant-based antidiabetic drugs, beverages, and supplements.

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Section: Resultsmentioning

confidence: 99%

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lahlou,

Carvalho,

Pereira

et al. 2024

Pharmaceutics

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“…STZ is the preferred drug used in experimental rodents to cause T1DM, which is administered at 55–65 mg/kg ( Wang-Fischer and Garyantes, 2018 , Aldayel et al, 2020 ). The diabetogenic role of STZ is mediated by the specific induction of pancreatic oxidative stress through activating ROS-generating enzymes and elevating the levels of free radicals and ROS ( Wang-Fischer and Garyantes, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…At this dose of STZ, several studies have shown that 60–80% of the pancreatic β-cells are damaged, thus leaving about 20–40% of active cells which can produce insulin ( Wang-Fischer and Garyantes, 2018 ). This results in rapid severe hypoinsulinemia and hyperglycemia, which over time, promotes oxidative and inflammatory damage to organs, and diabetic health problems eventually arise ( Aldayel et al,2020 ). Moreover, despite the increase in appetite, the treatment of STZ is linked to a loss in body weight, resulting from muscle wasting and a depletion of glycogen contents in the liver and muscle in response to impaired insulin availability and action ( Montano et al, 2010 , Aldayel et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Lepidium sativum alleviates diabetic nephropathy in a rat model by attenuating glucose levels, oxidative stress, and inflammation with concomitant suppression of TGF-β1

Alsuliam

Albadr

Alshammari

et al. 2023

Saudi Journal of Biological Sciences

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“…Recent study showed that the A. perryi extract has anti-inflammatory action and cytotoxic activities [ 28 ]. Moreover, another in vivo study showed its antidiabetic action due to hypoglycemic and insulin-releasing effects and hepatic antioxidant potentials in STZ-induced diabetic rats [ 29 ] and alloxan-induced diabetic rats [ 30 ]. Also, recent in vitro study showed antidiabetic and antioxidant activities of Aloe species [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats

Al-Gabri

Elnagar

Saghir

et al. 2022

BioMed Research International

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Objective. The present study was aimed at investigating the possible antiulcer activities of some natural phytochemicals Aloe perryi leaf extract (APLE) and flower extract (APFE) in addition to the date palm seed extract (DPSE) and the oily samples of DPSE in a pylorus ligation-induced ulcer model using ranitidine as a standard antiulcer drug. Background. Peptic ulcer is a prevalent gastrointestinal disorder due to hypersecretion of gastric acid. It affects four million people worldwide, and 2-10% of these ulcers are perforated and cause bleeding. This increases the risk of morbidity and mortality. So we aimed to introduce a primary study alternatively safe method for treating peptic ulcer. Materials and Methods. Forty-two Wistar Albino rats of either sex were randomly divided into seven groups (6/each). The pylorus ligation was done to induce ulcer in pretreated albino rats. The antiulcer activities of extracts were estimated at different dose levels (250 and 500 mg/kg) using ranitidine as a standard drug (50 mg/kg). Gastric volume, pH, and total and free acidity as well as ulcer index and percentage of ulcer inhibition were measured to elucidate the antiulcerogenic effects. Histological examination of gastric ulcer was also performed. Statistical analysis for the results was done where P < 0.05 was considered statistically significant. Results. Pylorus ligation for 6 h in control rats resulted in gastric ulcer which was indicated by the accumulation of gastric secretion and increased total acidity and decreased pH. The pretreatment of rats with APLE, APFE, and DPSE in addition to the oily samples of DPSE significantly inhibited the ulcers induced by pylorus ligation. These effects were attributed to significant reductions in total and free acidity, ulcer index, and gastric volume while there is a marked decrease in gastric pH (the antisecretory) as well as mucosal strengthening properties of these phytochemicals. Conclusion. These findings give these extracts the potential to be a promising tool for the management of gastric ulcer after performing further clinical and experimental studies. Our study demonstrated the promising antiulcer activity of extracts and oils in pyloric ligation-induced gastric ulcer. To the best of our knowledge, this is the first study to explore the antiulcer activity of these extracts; however, further investigations may be recommended for full details about this antiulcerogenic capacity.

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Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Cited by 8 publications

References 80 publications

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lepidium sativum alleviates diabetic nephropathy in a rat model by attenuating glucose levels, oxidative stress, and inflammation with concomitant suppression of TGF-β1

Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats

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