Hypoglycaemic effects of Ajuga extract in vitro and in vivo

Hsieh, Chang‐Wei; Cheng, Ju-Yun; Wang, Teng-Hsu; Wang, Hsiu-Ju; Ho, Wai‐Jane

doi:10.1016/j.jff.2013.10.010

Cited by 23 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the treated diabetic rats showed a significantly increase in catalase and SOD enzyme in liver and kidneys. Our findings confirm other investigations that reported a significant increase of antioxidant enzymes activities in tissues of diabetic rats treated with extracts from several plants (Hsieh et al, 2014).…”

Section: Discussionsupporting

confidence: 93%

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Jemaa¹,

Sarra²,

Hmed³

et al. 2015

International J. of Pharmacology

View full text Add to dashboard Cite

A B S T R A C TArtemisia herba alba was widely used in traditional medicine for the treatment of diabetes. The objective of this study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant effects of Artemisia herba alba extract on high fat diet and diabetic models. Wistar albinos male rats were divided into four groups, the first was fed with high fat diet, the second was mimetic diabetes type II with high fat diet combined with double low dose of streptozotocin , the third was a model of type I diabetes with high dose of streptozotocin and the fourth was a control group. The ethanolic extract of Artemisia herba alba was given orally (2 g kgG 1 b.wt.) and daily for a period of 8 weeks. Our results showed that Artemisia herba alba treatment reduces the blood glucose level significantly in type II diabetic group (17.50±2.34 g LG 1 vs., 10.93±3.19 g LG 1 ). The plasma lipoproteins HDL, LDL-cholesterol and the triglyceride levels were altered by high fat diet and also by streptozotocin injection. These levels were also reverted back to near normalcy by treatment. Lipid peroxidation was decreased significantly by Artemisia herba alba supplementation in high fat diet and diabetic groups (p<0.05). Treatment with investigational drug increases antioxidant enzymes activities (superoxide dismutase and catalase in liver and kidneys) for type I and type II diabetic groups. In conclusion, this study suggests that the Artemisia herba alba has a beneficial effect in controlling diabetes by reducing lipid peroxidation and increasing antioxidant enzymes activities, which reduces the risk of developing diabetes complications.

show abstract

Section: Discussionsupporting

confidence: 93%

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Jemaa¹,

Sarra²,

Hmed³

et al. 2015

International J. of Pharmacology

View full text Add to dashboard Cite

show abstract

“…In this respect, several Ajuga species are widely used. For example, A. iva is widely used in North-Africa ("chandgoura") for its antidiabetic properties [7][8][9], whereas A. remota is largely known for its antimalarial properties [6,10], and A. bracteosa ("jan-i-adam"), used in India and Pakistan, has anti-inflammatory, antihelminthic, anti-plasmodial and hepato-protective effects [11].…”

Section: Previous Reviews Have Underlined the Diversity Of Ecdysteroimentioning

confidence: 99%

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Bakrim

Ngunjiri²,

Crouzet

et al. 2014

Natural Product Communications

View full text Add to dashboard Cite

Phytoecdysteroids are plant analogues of insect moulting hormones and are used by plants to repel or disturb phytophagous insects. They are also active on mammals and present in many plants used in traditional medicine. The Ajuga genus contains several such species, which occur in various pharmacopoeias. We report the isolation and identification of major and minor ecdysteroids present in two Ajuga species, A. iva and A. remota, both of which are used as medicinal plants in Africa. Three minor ecdysteroids (abutasterone, ponasterone A and sidisterone) have been found for the first time in the Ajuga genus.

show abstract

“…Ultrasonic extraction is a novel method used to enhance production yield and to avoid thermal damage ( 28 ). It has been used in previous studies to extract natural products ( 29 ) and improve solvent extraction, mainly due to the mechanical effects of cavitational bubble collapse, causing better solvent penetration into plant materials ( 30 , 31 ). In the single factor experiment of the present study, the yield of flavonoids reached the maximum 4.87% by using ultrasonication for 40 min.…”

Section: Discussionmentioning

confidence: 99%

Extraction of flavonoids from Chrysanthemum morifolium and antitumor activity in vitro

et al. 2017

View full text Add to dashboard Cite

The aim of the present study was to optimize flavonoid extraction from Chrysanthemum morifolium and to study the antitumor effects of flavonoids on human gastric cancer MKN45 cells in vitro. A single factor experiment was designed and the extraction process was optimized using an orthogonal test. MKN45 cells were treated with different concentrations of flavonoid from Chrysanthemum morifolium for 24 and 48 h and the inhibitory effect on the MKN45 cells was evaluated using an MTT assay. Following staining with Annexin V-fluorescein isothiocyanate/propidium iodide, flow cytometry was performed. The optimized flavonoid extraction conditions were as follows: Duration of ultrasonic treatment: 35 min; ethanol concentration: 75%; extraction temperature: 80°Cand liquid-to-solid ratio 25: 1. Under the above conditions, the extraction rate of flavonoids was 5.24%. When compared with a blank control group, flavonoids extracted from Chrysanthemum morifolium inhibited the proliferation of MKN45 cells in a dose- and time-dependent manner. Furthermore, in cell groups treated with low, moderate and high concentrations of flavonoid, it was observed that the proportion of apoptotic cells increased in a dose-dependent manner. The extraction process optimized by the orthogonal test achieved a high yield and satisfactory extraction efficiency. Additionally, the experiment demonstrated that flavonoids from Chrysanthemum morifolium inhibited the growth of MKN45 cells and induced their apoptosis. Thus, flavonoids from Chrysanthemum morifolium exerted antitumor effects on MKN45 cells, which may be exploited as a potential antitumor therapeutic for gastric cancer.

show abstract

Hypoglycaemic effects of Ajuga extract in vitro and in vivo

Cited by 23 publications

References 31 publications

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Extraction of flavonoids from Chrysanthemum morifolium and antitumor activity in vitro

Contact Info

Product

Resources

About