Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets

An overview on antidiabetic medicinal plants having insulin mimetic property

“…Aqueous extract of Teucrium polium crude extract is able to enhance insulin secretion through enhancing insulin secretion by the pancreas [44] . The insulinotropic properties of Teucrium polium extracts can be attributed to the presence of apigenin existing only in methanol fraction but not in aqueoue fractions [45] .…”

Inhibitory Activity on Xanthine Oxidase and Antioxidant Properties of <i>Teucrium polium</i>

“…Teucrium polium and related species (Teucrium oliverianum and Teucrium mascatense) are commonly used in folk medicine for various types of pathological conditions. Previous studies have demonstrated some of the pharmacological effects of Teucrium polium such as anti-bacterial [12], anti-inflammatory [13,14], anti-ulcerogenic [15], anti-nociceptive [14,16], antidiabetes [17], antihypertensive [18], hypo-lipidemic [19] and calcium antagonist [20]. The goal of this study was to investigate the antioxidant and radical scavenging effects of the T poluim and its active fractions by applying various established in vitro assays.…”

Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice

“…It might also have been due to the extract stimulating β cells in islet of Langerhans, increased serum insulin and reduced blood sugar [16]. Glucose lowering effect might also be attributed to the increased release of insulin from regenerated β-cells [17,18], restored insulin sensitivity [19], interference on absorption of dietary carbohydrates as well as disaccharides in small intestine [20] or facilitated utilization of glucose by peripheral tissues mediated by GLUT-4, an insulin dependent glucose transporter [21]. The lowering of blood glucose levels by M. putterkloides in the same manner regardless of the dosage might suggest that the extract may reflect uptake of the active constituents through saturable active transport; it may also reflect maximum hypoglycemic activity at the lowest dose used (50 mg/kg body weight).…”