Hypoglycaemic effect of quinolizidine alkaloids — lupanine and 2-thionosparteine on non-diabetic and streptozotocin-induced diabetic rats

Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice

“…Although there are reports on the anti-diabetic activities of alkaloids isolated from several other plants (Ko et al, 2005;Bobkiewicz-Kozłowska et al, 2007;Kim et al, 2007;Jung et al, 2008;Zhang et al, 2008), the biological activities of the spermidine alkaloids isolated from the roots and barks of this plant are yet to be defined (Ahmad et al, 1992;Goyal et al, 2009).…”

The spatial structure of 13α-hydroxy-2-thionosparteine – a potential hypoglycemic agent – and some related compounds

“…The dependence of the C12 and C14 chemical shifts on the type of compound may suggest a slightly different conformational equilibrium in lactam derivatives (4,8,10) and thiolactam ones (7 and 9).…”

“…The solvent was evaporated under reduced pressure giving 2.690 g of the crude light yellow product, which was crystallized from methanol-hexane mixture. Table 1 13 C chemical shifts of 13a-hydroxylupanine (4), 13a-t-butyldimethylsilyloxylupanine (8), 13a-hydroxy-2-thionosparteine (7), 13a-t-butyldimethylsilyloxy-2-thionosparteine (9), 2-thionosparteine (5) and 13a-trimethylsilyloxylupanine (10) Zeisberg [14]. b Ref.…”

“…According to Kubo et al [9] ''the basic structure responsible for the hypoglycemic activity was presumed to be quinolizidin-2-one which has a substituent stereochemically similar to (-)-multiflorine on the B ring." Recently, 2-thionosparteine (5) was found to have a stronger hypoglycemic effect than glibenclamide, the compound used in the treatment of diabetes [10]. Although 2-thionosparteine (5) has a spatial structure similar to that of multiflorine (6), it has no carbonyl group at position 4, so this group is not a necessary factor for the potential antidiabetic drug.…”

Current methods of the modeling of experimental diabetes mellitus type 2: a literature review

“…It seems to be interesting the model of experimental DM2T based on a partial affection of the beta cells in result of repeated administration of low doses of STZ to adult rats [8]. Diabetes is induced by the everyday intraperitoneal administration of ex temporo solution of STZ (15 mg/kg of STZ in 1mM citrate buffer, pH=4.5) during 5 days to mature Wistar male rats with 280-300 g weight.…”