Hypoglycaemic Effect of Lycopene in Streptozotocin-Induced Diabetic Wistar Rats

Eze, Ejike Daniel; Mohammed, Aliyu; Tanko, Y.; Ahmed, Amran; Rabiu, Karimah Mohammed

doi:10.9734/bjmmr/2015/15908

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Lycopene is the most predominant carotenoid in tomatoes and has the highest antioxidant property among all dietary carotenoids (Rao and Agrawal, 1999). Studies reported on lycopene's effects in STZ-induced diabetic animals included altered thyroid profile (Eze et al, 2015a), atherogenic cardiovascular risk (Eze et al, 2015b), kidney antioxidant enzyme activity (Eze et al, 2015c), a hypoglycemic effect (Eze et al, 2015d), altered liver markers and glucokinase activity of diabetic animals (Eze et al, 2016) as well as histological changes (Soleymaninejad et al, 2017). Haribabu et al (2013) found that lycopene at 2 and 4 mg/kg body weight in combination with glipizide and metformin had antidiabetic activity on the 21st day of treatment in alloxaninduced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Eze¹,

Afodun²,

Sulaiman³

et al. 2018

J. Diabetes Endocrinol.

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The purpose of this study is to evaluate the capacity of lycopene against diabetes-induced oxidative damage in Wistar rats. Thirty Wistar rats of both sexes, twenty-five of which were diabetic, were used. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight and it was confirmed by the elevated blood glucose ≥200 mg/dl after three days. The rats were divided randomly into groups 1 to 6, each containing 5 rats. Group 1 (Normal control) and Group 2 (Diabetic control) rats were administered 0.5 ml of olive oil; Groups 3, 4, and 5 rats were respectively administered 10, 20 and 40 mg/kg body weight of lycopene, while Group 6 rats were administered 2 mg/kg body weight of Glibenclamide. All administrations were done orally and once daily for twentyeight days. At the end of the treatment, serum levels of antioxidant enzymes, cortisol and malondialdehyde (MDA) were determined. Administration of graded doses of lycopene to diabetic animals significantly (P<0.05) decreased the blood glucose concentration after four weeks of treatment when compared to diabetic untreated animals. Serum levels of cortisol and MDA (index of oxidative stress) were reduced while there were up-regulated activities of serum endogenous enzymes (superoxide dismutase, catalase and glutathione peroxidase) in diabetic animals treated with all doses of lycopene when compared with diabetic untreated animals. Overall, lycopene attenuated the biomedical alterations in STZ-induced diabetic Wistar rats. Lycopene therefore possesses antioxidant activity at the doses tested in this study.

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Section: Introductionmentioning

confidence: 99%

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Eze¹,

Afodun²,

Sulaiman³

et al. 2018

J. Diabetes Endocrinol.

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“…18,22 The large number of conjugated double bonds in lycopene makes it a potent antioxidant because the delocalization of π electrons that occurs along the double bond allows the neutralization reaction of molecules containing unpaired electrons. 19,35 The radical neutralization reaction of lycopene can occur in various ways, including adding radicals to the polyene chain, electron transfer from lycopene to radicals, or eliminating hydrogen atoms from lycopene. 41 These three reactions are explained in succession as follows: (i) adding radicals to the polyene chain of lycopene: Lycopene + R• R-Lycopene•, (ii) electron transfer from lycopene to the radical: Lycopene + R• Lycopene •+ + Rand (iii) hydrogen elimination from lycopene: Lycopene + R•  Lycopene• + RH.…”

Section: Lycopene Ameliorates Oxidative Stress In Dmmentioning

confidence: 99%

“…16 The large number of conjugated double bonds that lycopene has is the basis of its antioxidant properties. [17][18][19] Moreover, lycopene also has anti-inflammatory effects. Many studies have shown that lycopene shows potential beneficial effects in cancer and lifelong diseases, such as cardiovascular, neurodegenerative, and metabolic diseases which includes diabetes.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review

2021

TJNPR

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Lycopene has received a lot of attention because of its benefits in various chronic diseases such as cancer, cardiovascular, neurodegenerative, and metabolic diseases such as diabetes. Various studies using cell culture, animals, and humans as subjects have proven the benefits of lycopene in diabetes, but none have yet explained its molecular mechanism in detail. Therefore, this study aims to summarize and describe the benefits of lycopene in diabetes mellitus and the potential underlying mechanisms. This study is a literature review that uses articles obtained from the PubMed and Google Scholar databases by entering the keywords lycopene, diabetes, oxidative stress, inflammation, apoptosis, and autophagy either separately or in combination to obtain a logical concept. There are 33 main articles summarized and discussed in this study. Lycopene shows potential use in the therapy and prevention of diabetes complications, particularly through its antioxidant and anti-inflammatory activities. Lycopene also increases insulin signaling activity via the PI3K/AKT pathway. Moreover, lycopene supplementation contributes to decrease apoptosis in brain cells and weakens apoptosis in podocytes through the autophagy process. Knowing these benefits, lycopene supplementation in diabetics needs to be considered, but further research is needed in the form of large clinical trials to prove the benefits of lycopene in diabetes and the optimal dosage required.

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“…DISCUSSION: The present study revealed a dosespecific pharmacologic activity of the aqueous leaf extract of N. laevis at 100 and 200 mg/kg body weight. Alloxan monohydrate is a hydrophilic and unstable compound of glucose analogues that specifically accumulate in pancreatic β-cells via the Glucose Transporter 2 41 to induce hyperglycaemia (type I diabetes) 9,42 . The cytotoxic activity of alloxan monohydrate involves oxidation of essential sulphydryl (-SH) group, inhibition of glucokinase enzymes, generation of free radicals and disturbance of intracellular calcium homeostasis 42 .…”

Section: Day 14mentioning

confidence: 99%

“…Diabetes mellitus is therefore a group of metabolic diseases characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action, or both. Report have it that protection against the alloxan-induced hyperglycaemia can be achieved by a combination of superoxide dismutase and catalase, which completely prevents redox imbalance between alloxan, ROS species generation and antioxidant status 9,10 . Studies have also been reported in the open scientific literature on induced hyperglycaemia following administration of alloxan and or extracts of medicinal plants 5,11,12,13,14 .…”

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confidence: 99%

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2018

IJPSR

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The antihyperglycaemic activity of aqueous leaf extract of Newbouldia laevis (ALENL) was evaluated in rats. Twenty-five rats of both sexes (120-160 g) were divided into five groups (A-E) of 5 animals each. Group A (control) rats were administered 0.5 ml of distilled water (DW) orally while those in group B received 100 mg/kg body weight of ALENL. Animals in groups C, D and E which induced into hyperglycaemia (intraperitoneal administration of 150 mg/kg body weight of alloxan) were also administered DW, 100 and 200 mg/kg body weight of ALENL respectively, once daily for 14 days. Blood glucose levels (BGL) were determined at an interval of two days. Alloxan significantly (p<0.05) increased BGL in the DW treated hyperglycaemic animals (DWTHA) from 48.00 ± 1.79 to 142.80 ± 2.35 mg/dl after 24 h. After two days, administration of the extract at 100 and 200 mg/kg body weight increased blood glucose level, but this increase was not statistically significant (p>0.05) when compared with the DWTHA. On day 4, the extract at both doses decreased blood glucose level, but this decrease was not statistically significant (p>0.05) when compared with the DWTHA. On days 6, 8, 10, 12 and 14, the extract at both doses decreased blood glucose level, but this decrease was statistically significant (p<0.05) when compared with the DWTHA. The study indicates that the extract at both doses possesses antihyperglycaemic properties which may have acted by stimulating glucose utilization by peripheral tissues or increasing insulin production by the pancreas from regenerated β-cells.

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Hypoglycaemic Effect of Lycopene in Streptozotocin-Induced Diabetic Wistar Rats

Cited by 10 publications

References 30 publications

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review

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