Hypoglycaemic effect ofBawang Dayakextracts (Eleutherine palmifolia(L.) Merr.) on Sprague Dawley rats

Abstract

The Dayak tribe in Kalimantan has long used bawang dayak as a traditional cure for various degenerative diseases. Previous research showed that bawang dayak bulb has an active compound that can inhibit the enzyme alpha-glucosidase, known as alpha-glucosidase inhibitor (AGI). Compounds that have such ability has a potential in controlling blood glucose level in diabetes mellitus. This research aims to study the effective dosage of aqueous extract and ethanolic extract of bawang dayak bulb as an AGI through an oral glucose tolerance test in male Sprague Dawley rats. Experimental rats were divided into 14 groups, 7 for the ethanolic extract test and 7 for the aqueous extract test. The extracts were applied in 5 dosage levels in each test, with acarbose as a drug control and distilled water as a positive control. Data were plotted to determine the area under the curve (AUC). The effective dosage was the lowest dosage that gave a significantly smaller AUC value than the AUC value of the positive control group. The effective dosage for bawang dayak aqueous extract and bawang dayak ethanolic extract was 200 mg/kg and 100 mg/kg, respectively.

Organoleptic Analysis, Quality Requirement, And Color Determination of Tilapia Nuggets with Eleutherine palmifolia Extract Coating

“…The test results showed that the antioxidant activity of tilapia nuggets with Dayak onion ethanol extract coating was more significant than tilapia nuggets with Dayak onion water extract coating. In line with Febrinda et al (2022), the effective dose of Dayak onion water extract is greater than ethanolic extract in inhibiting the action of alpha-glucosidase enzymes. It shows that ethanol extract has a higher ability than aqueous extract to inhibit the activity of alpha glucosidase enzyme.…”

Evaluasi Kadar Senyawa Fenolat, Flavonoid Total, serta Aktivitas Antioksidan Secara in vitro dalam Ekstrak Metanol Bawang Dayak (Eleutherine palmifolia (L.) Merr

“…glukosidase(Febrinda et al 2022), aktivitas antibakteri(Wicaksono et al, 2018), serta berpotensi sebagai antimikoba terhadap MRSA (methicilin-resistant Staphylococcus aureus) (Subramaniam et al 2012). dan hasil positif terbentuk warna merah coklat atau kuning.…”