Hypoglycaemic effect of Artemisia herba alba. I. Effect of different parts and influence of the solvent on hypoglycaemic activity

Al-Khazraji, Shahba M.; Al-Shamaony, Loai A.; Twaij, Husni A.A.

doi:10.1016/0378-8741(93)90064-c

Cited by 50 publications

(21 citation statements)

References 4 publications

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“…L'armoise blanche de la région de Biskra pour les nomades du désert [10]. Des études ethnopharmacologiques ont montré l'intérêt de l'armoise blanche contre le diabète, grâce à son activité hypoglycémiante, ainsi que contre l'hypertension, mais également la présence d'activité emménagogue [6,7,8,24,35]. Les extraits aqueux d'armoise blanche montrent des activités antileshmaniose, antigénotoxiques, antidiabétiques, antibactériennes et antispasmodiques [11,22,27,37].…”

Section: Introductionunclassified

Chemical composition of the essential oil of Artemisia herba-alba issued from the district of Biskra (Algeria)

Bezza¹,

Mannarino²,

Fattarsi³

et al. 2010

Phytothérapie

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L'huile essentielle (HE) d'Artemisia herba-alba Asso (Asteraceae), obtenue par entraînement à la vapeur des sommités, a été étudiée par CPG-FID et CPG-SM. La détermination de l'HE correspond à 0,95 ml pour 100 g de matière sèche. Quarante-six composés correspondant à 92,61 % ont été identifiés. L'HE contient en majorité de l'acétate de cis-chrysanthényle (25,12 %), du 2E,3Z-2-éthyliden-6-méthyl-3,5-heptadiènal (8,39 %), de l'α-thujone (7,85 %), de l'acétate de myrtényle (7,39 %), de la verbénone (7,19 %), de la chrysanthénone (4,98 %). La composition chimique est très spécifique pour cette plante algérienne.Mots clés : Artemisia herba-alba -Armoise blanche -Composition de l'huile essentielle -Acétate de cis-chrysanthényle -Chémotype Chemical composition of the essential oil of Artemisia herba-alba issued from the district of Biskra (Algeria)Abstract: Artemisia herba-alba Asso (Asteraceae) essential oil (EO), obtained by hydrodistillation from aerial parts, and was investigated using GC-FID and GC-MS techniques. The EO yield, based on dry weight, was 0.95% (v/w). Forty six components corresponding to 92.61% of the oil were identified. The EO contained in majority: cis-chrysanthenyl acetate (25.12%); (2E,3Z) 3,5-heptadienal-2-ethyliden-6-methyl (8.39%); α-thujone (7.85%); myrtenyl acetate (7.39%); verbenone (7.19%), chrysanthenone (4.98%). Chemical composition was very specific for this Algerian plant.

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Section: Introductionunclassified

Chemical composition of the essential oil of Artemisia herba-alba issued from the district of Biskra (Algeria)

Bezza¹,

Mannarino²,

Fattarsi³

et al. 2010

Phytothérapie

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“…These species include Trigonella foenum-graecum [48][49][50], Artemisia herbaalba [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69], Juglans regia [60], Lavandula maroccana [24,39], Salvia lavandulifolia [61], Olea europaea [21, 24,38,39,52,54,62,63], Citrullus colocynthis [64][65][66], Nigella [67,68], Argania spinosa [47,69], Ajuga iva [70,71], Capparis spinosa [72], Cistus laurifolius [73], Teucrium polium [74], Ziziphus lotus [75], Zea mays [76] and Hibiscus sabdariffa [63]. To the best of our knowledge, Cistus creticus and Cladanthus scariosus are mentioned for the first time for treating diab...…”

Section: Ethnobotanical Indicesmentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used for the Treatment of Diabetes in the Tizi n’ Test Region (Taroudant Province, Morocco)

Katiri¹,

Barkaoui²,

Ms³

et al. 2017

J Pharmacogn Nat Prod

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“…FTE solution was prepared by using a modified method that has been previously described. [12,13] The extract was freshly dissolved in dimethyl sulfoxide (DMSO, 2 ml) and normal saline (19 ml) before use in each case. Urine samples were collected for 1 h (control period) for measurements of urine flow and Na + and K + excretion rates, following which the extract solution was infused at 0.06 μg·min −1 for 1.5 h (treatment period), resulting in a total dose of 18 g·kg −1 (for a 300-g rat).…”

Section: Treated Groupmentioning

confidence: 99%

Effects ofFicus thonningii(Blume) [Morarceae] Stem-Bark Ethanolic Extract on Blood Glucose, Cardiovascular and Kidney Functions of Rats, and on Kidney Cell Lines of the Proximal (LLC-PK1) and Distal Tubules (MDBK)

et al. 2007

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Previous observations indicate that Ficus thonningii (Blume) [Moraceae] stem-bark extracts may be useful in the control of diabetes mellitus. Accordingly, we investigated in some experimental animal paradigms the effects of F. thonningii stembark ethanolic extract (FTE) on renal and cardiovascular functions as complications of diabetes. Oral glucose tolerance tests were conducted in separate groups of non-diabetic and STZtreated diabetic rats given glucose load (0.86 g.kg ). Rats treated with deionized water (3 mL.kg −1 p.o.), or metformin (500 mg.kg −1 p.o.) acted as untreated and treated positive controls, respectively. Blood glucose was monitored at 15-min intervals for the first hour, and hourly thereafter for 3 h. Acute effects of FTE on kidney function and mean arterial blood pressure (MAP) were investigated in anaesthetized rats challenged with hypotonic saline after a 3.5-h equilibration for 4 h of 1 h control, 1.5 h treatment, and 1.5 h recovery periods. FTE was added to the infusate during the treatment period. Chronic effects of FTE were studied in individually caged rats treated daily with FTE (120 mg.kg −1 , p.o.) for five weeks. Cytotoxicity of FTE was assessed by dye-reduction colorimetric (MTT) assay on MDBK and LLCPK1 kidney cell lines exposed for 24 h, 48 h, and 72 h to graded concentrations of the extract. Myocardial contractile performance was evaluated on rat isolated atrial muscle strips. FTE, like metformin, decreased blood glucose levels in non-diabetic and STZ-diabetic rats. Both acute and chronic FTE treatments did not affect renal function. In vitro studies demonstrated that FTE increased MDBK cell metabolic activity by an average of 15% (72 h), and LLCPK1 mirrored the controls. Acute intravenous infusion of FTE reduced the MAP from 119 ± 1 mmHg to 98 ± 4 mmHg. The MAP also was reduced throughout the fiveweek experimental study period. FTE also produced concentrationdependent, negative inotropic and chronotropic effects on rat isolated, electrically driven left-, and spontaneously beating right-, atrial muscle preparations. Our experimental findings suggest that FTE possesses reno-and cardio-protective effects in diabetes mellitus.

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Hypoglycaemic effect of Artemisia herba alba. I. Effect of different parts and influence of the solvent on hypoglycaemic activity

Cited by 50 publications

References 4 publications

Chemical composition of the essential oil of Artemisia herba-alba issued from the district of Biskra (Algeria)

Chemical composition of the essential oil of Artemisia herba-alba issued from the district of Biskra (Algeria)

Ethnobotanical Survey of Medicinal Plants Used for the Treatment of Diabetes in the Tizi n’ Test Region (Taroudant Province, Morocco)

Effects ofFicus thonningii(Blume) [Morarceae] Stem-Bark Ethanolic Extract on Blood Glucose, Cardiovascular and Kidney Functions of Rats, and on Kidney Cell Lines of the Proximal (LLC-PK1) and Distal Tubules (MDBK)

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