Hypoglycaemic activity of Geranium core‐core, Oxalis rosea and Plantago major extract in rats

Abstract

The hypoglycaemic activity of 'Core-core' (Geranium core-core, Geraniaceae), 'Culle' (Oxalis rosea, Oxalidaceae) and 'Llanthn' (P lantago major, Plantaginaceae) crude extracts was assessed in normoglycaemic rats. Furthermore, the hypoglycaemic activity of Core-core extract was evaluated in alloxan-diabetic rats. A single oral dose of 500 mg/kg Core-core extract significantly reduced glycaemia in normal rats under glucose tolerance test conditions (p<O.Ol), while Culle and Llanthn were devoid of activity. The effect was lower than a single oral dose of 100 mg/kg tolbutamide. Afler 7 days oral treatment at 250 mg extractlkg body weight, Core-core significantly reduced glycaemia ( p < 0.01) in normal rats under oral glucose tolerance conditions. In alloxan-diabetic rats, a single oral dose of 500 mglkg and chronic treatment at 250 mglkg Core-core extract significantly reduced glycaemia in glucose tolerance test conditions at p < 0.05 and p < 0.01, respectively. During the acute oral toxicity study, animals treated with Core-core extract exhibited no symptoms of drug-induced toxicity with doses up to 5 g/kg.

The traditional uses, chemical constituents and biological activities of Plantago major L. A review

“…The reduction in arterial blood pressure was not significant (Schmeda-Hirschmann et al, 1992). Rodriguez et al (1994) have tested a 70% ethanol extract for its hypoglycaemic activity in normoglycaemic rats without finding any significant effect. The extract was given orally at a dose of 500 mg/kg.…”

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

“…Phenolic glycoside [183]. Antioxidative flavonoids [184] Significant antihyperglycemic effect in experimental diabetic rats [185,186] 20 Plantaginaceae P. ovata Forsk. (decoction of seeds [69])…”

Bioactivity of the Geranium Genus: A Comprehensive Review

“…Rodriguez et al evaluated the hypoglycaemic activity of a 70% aqueous EtOH extract of G. core-core in normoglycaemic and alloxan-induced diabetic rats [21]. The results showed that a single oral dose of 500 mg/Kg, as well as the chronic administration of 250 mg/Kg (7 days), significantly reduced blood glucose levels both of normoglycaemic and alloxan-diabetic rats under glucose tolerance test conditions.…”

“…20 Extraction at 130ºC. 21 Caffeic acid (IC50 = 1.7 µg/mL) was used as reference compound. 22 Caffeic acid (IC50 = 2.0 µg/mL) was used as a reference compound.…”