Hypoglycaemic activity of four plants used in Chilean popular medicine

Lemus, Igor; Garcı́a, Ricardo; Delvillar, E.; Knop, G.

doi:10.1002/(sici)1099-1573(199903)13:2<91::aid-ptr350>3.0.co;2-8

Cited by 79 publications

(46 citation statements)

References 3 publications

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“…Also, in the case of metabolic and nutritional pathologies, it is worth noting the use of the genus Rubus for hypoglycemia in Cyprus (Rubus sanctus) and Spain (Rubus ulmifolius). Different species of this genus have proven effective for treating hypoglycemia in experimental assays (Lemus et al, 1999;Jouad et al, 2002).…”

Section: Medicinal Usementioning

confidence: 99%

Medicinal plants in the Mediterranean area: Synthesis of the results of the project Rubia

González-Tejero

Casares-Porcel

Sánchez-Rojas

et al. 2008

Journal of Ethnopharmacology

415

238

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Aim of study: Within the scope of the European project RUBIA (ICA3-2002-10023), research has been performed on the traditional use and handling of plant species in several Mediterranean countries, Albania, Algeria, Cyprus, Egypt, Italy, Morocco, and Spain. This paper synthesises the chief results related to the medicinal utilization of those plants. Material and methods:The information has been gathered by means of semi-structured interviews (1256) and techniques of participant observation with 803 informants. In each of the participating countries the study areas were selected by means of uniform criteria defined at the beginning of the study. Results and conclusions:A total of 985 species have been catalogued, of which 406 have medicinal use. This work constitutes the first comparative study performed with ethnobotanical data gathered by a coordinated methodology in the Mediterranean area. An exhaustive list is provided for the species catalogued, indicating the regions where each plant was mentioned. Ethnopharmacological relevance: This information underlines the ethnobotanical richness of the region and the need to broaden this study to other areas of the Mediterranean. Furthermore, this constitutes a base for future phytochemical and pharmacological studies which could lead to new therapeutic products.

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Section: Medicinal Usementioning

confidence: 99%

Medicinal plants in the Mediterranean area: Synthesis of the results of the project Rubia

González-Tejero

Casares-Porcel

Sánchez-Rojas

et al. 2008

Journal of Ethnopharmacology

415

238

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“…[2][3][4] Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity. [5][6][7] Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources.…”

mentioning

confidence: 99%

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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Rosaceae consists of a large family of plants, represented by fruits such as plums, cherries, damson plums, quinces, strawberries, pears and peaches.1) The plants to the genus Rubus, have been traditionally used to treat different diseases, particularly diabetes.2-4) Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity.5-7) Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives. 8,9,11) Recently, we have shown that another species, R. imperialis, presents hypoglycaemic, cytotoxic and antinociceptive actions. 9,[11][12][13] The main isolated active compound, named niga-ichigoside F1, showed marked antinociception and its mechanism of action appears to be related to the dopaminergic, cholinergic, glutamatergic, and tachykininergic and oxinitrergic systems. 14)Rubus rosaefolius, popularly known as "amora-do-mato" or "amora-vermelha" in Brazil, is a shrub measuring between 4 and 5 m, and is well distributed in the South of Brazil. 1,15) The current study extends our previous work on the biological properties of the Rubus species, and describes its phytochemical analysis and in vivo antinociceptive activity against two pain models in mice (writhing and formalin tests) of the extract, fractions and a pure compound isolated from the aerial parts of R. rosaefolius. Phytochemical Analysis Air-dried material from R. rosaefolius (700 g) was cut into small pieces and macerated with methanol at room temperature for 7 d. After filtration, the solvent was removed by rotatory evaporation under reduced pressure, yielding the respective methanolic extract (ME). Parallel to this, a hydroalcoholic extract (HE) was prepared through maceration of 100 g of plant with an ethanol-water (50 : 50) mixture and stored for use in the pharmacological test. The methanolic extract (35 g), were then suspended in a MeOH : water mixture (9 : 1) and successively partitioned with n-hexane, dichlomethane, ethyl acetate and n-butanol, to provide the respective fractions. The hexane and dichloromethane fractions (7.4, 4.2 g) were chromatographed on silica gel column eluted with a hexane : acetone mixture with increasing polarity. Similar fractions, which showed a positive reaction with anisaldehyde sulfuric reagents, were combined and rechromatographed as in the The Rubus species has been used in folk medicine to treat several ailments, including infectious and dolorous diseases. In this work we evaluate the phytochemical and analgesic activity of hydroalcoholic extract (HE), some fractions (hexane, dichloromethane, ethyl acetate and butanolic), as well as a pure compound denoted as 28-methoxytormentic acid (1) obtained from aerial parts of R. rosaefolius. The compounds were isolated and identified by chromatographic and spect...

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“…In 1999, a Chilean study discovered the actions of pata de vaca in alloxan-induced diabetic rats. The study showed that pata de vaca exerted exceptional hypoglycemic effects, and generated a decrease of glycemia in alloxan diabetic rats by thirty nine percent [137].…”

Section: Bauhinia Candicans (Pata De Vaca)mentioning

confidence: 95%

Alternative Medicine in Diabetes - Role of Angiogenesis, Oxidative Stress, and Chronic Inflammation

Elrefaei¹,

Abduljawad²,

Alghamdi³

2014

Rev Diabet Stud

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■ AbstractDiabetes is a chronic metabolic disorder that is characterized by hyperglycemia due to lack of or resistance to insulin. Patients with diabetes are frequently afflicted with ischemic vascular disease and impaired wound healing. Type 2 diabetes (T2D) is known to accelerate atherosclerotic processes, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation. Herbal medicines and naturally occurring substances may positively affect diabetes management, and could thus be utilized as costeffective means of supporting treatment in developing countries. Natural treatments have been used in these countries for a long time to treat diabetes. The present review analyses the features of aberrant angiogenesis, abnormalities in growth factors, oxidative stress, and metabolic derangements relevant to diabetes, and how herbal substances and their active chemical constituents may counteract these events. Evidence for possible biochemical effectiveness and limitations of herbal medicines are given, as well as details regarding the role of cytokines and nitric oxide.

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Hypoglycaemic activity of four plants used in Chilean popular medicine

Cited by 79 publications

References 3 publications

Medicinal plants in the Mediterranean area: Synthesis of the results of the project Rubia

Medicinal plants in the Mediterranean area: Synthesis of the results of the project Rubia

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Alternative Medicine in Diabetes - Role of Angiogenesis, Oxidative Stress, and Chronic Inflammation

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