Hypoglycaemia in Type 2 diabetes

Heller, Simon

doi:10.1016/j.diabres.2008.09.026

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…Diabetic ketoacidosis (DKA) is characterized by hyperglycemia, ketone bodies, and metabolic acidosis, and it can be initiated by a deficit in insulin levels [3]. In contrast, the hypoglycemia in diabetic patients -the most common type of hypoglycemia -usually develops due to an excess of therapeutic insulin [4]. Thus, the clinical manifestations of hypoglycemia are usually not observed in diabetic patients after insulin is discontinued.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Hypoglycemia due to Insulin Antibody after Insulin Treatment of Diabetic Ketoacidosis

et al. 2010

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Hypoglycemia in diabetic patients is usually caused by excessive exogenous insulin or the administration of an insulin secretagogue relative to the prevailing glucose concentration. Thus, the clinical manifestations of hypoglycemia are usually not observed in diabetic patients after either insulin or an oral hypoglycemic agent is discontinued. In contrast, diabetic ketoacidosis results from relative or absolute insulin deficiency. Although about 40% of diabetic patients who inject human insulin have insulin antibodies, these antibodies seldom significantly affect the glycemic control. It has not been reported in the literature that insulin antibody in the setting of human insulin therapy is associated with diabetic ketoacidosis and subsequent hypoglycemia. We describe here a rare case of spontaneous hypoglycemia due to insulin antibody after the improvement of diabetic ketoacidosis in a patient with type 2 diabetes mellitus and who had been treated with human insulin. (Endocrinol Metab 25:217-220, 2010)

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Section: Introductionmentioning

confidence: 99%