Hypoglycaemia and Human Insulin

The Contribution of Medications to Hypoglycemia Unawareness

“…The fraction of patients reporting altered symptoms of hypoglycemia was consistent with the fraction of all longterm patients reporting these changes. 12 One study 13 evaluating patients who reported that they had developed hypoglycemia unawareness after being switched to human insulin reported no differences in symptomatic or hormonal responses to hypoglycemia.…”

Hypoglycemic Symptoms and Frequency of Severe Hypoglycemia in Patients Treated With Human and Animal Insulin Preparations

“…However, such classifications of various warning symptoms are controversial. Thus, the symptoms hunger, unrest, anxiety, and visual disturbances have been classified either as autonomic or as neuroglycopenic symptoms (6,9,10). It has been calculated that by reallocating the symptoms unrest and anxiety in the study of Berger et al (6), the significance of the suggested difference between the two insulin species would have disappeared (11).…”

“…These studies have been criticized because of retrospective data collection, patient selection, inappropriate questionnaire design, and data analysis (4,(9)(10)(11)(12)(13)(14)(15).…”

Nice insulins, pity about the evidence

“…Reports claimed that patients transferred to human insulin lost their warning symptoms of hypoglycaemia, and human insulin was also held to blame when a succession of young people treated with insulin died unexpectedly in their sleep. Public fears were easily aroused by the spectre of genetically modified insulin [13]. In the event, blinded crossover trials revealed that patients who reported loss of warning on human insulin could not tell the insulins apart [14,15].…”