Hypofrontality in panic disorder and major depressive disorder assessed by multi-channel near-infrared spectroscopy

Ohta, Haruhisa; Yamagata, Bun; Tomioka, Haruaki; Takahashi, Taro; Yano, Masataka; Nakagome, Kazuyuki; Mimura, Masaru

doi:10.1002/da.20463

Cited by 77 publications

(43 citation statements)

References 27 publications

(51 reference statements)

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“…34 Recent fMRI studies have demonstrated robust activation by the WFT in the left Brodmann's area (BA) 44/45, as well as adjacent BA46 and BA47, together with the premotor cortex (BA6) and insula. 35 Previous studies using NIRS [23][24][25][26] demonstrated bilateral frontal activation during the WFT in healthy controls, suggesting that not only the left, but also the right frontal lobe may play crucial roles in voluntary speech intention and/or attentional resources required for performing the WFT. Interconnected areas such as these are believed to participate in a functional language network subserving word output.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are consistent with those of previous studies of activation in major depression using NIRS. [23][24][25][26] Neuropsychological studies of patients with lesions in the left prefrontal areas have revealed impairment of word list generation, suggesting the importance of the prefrontal areas for WFT. 34 Recent fMRI studies have demonstrated robust activation by the WFT in the left Brodmann's area (BA) 44/45, as well as adjacent BA46 and BA47, together with the premotor cortex (BA6) and insula.…”

Section: Discussionmentioning

confidence: 99%

“…These findings show that patients with LOD are more likely to display cortical dysfunction in the lateral prefrontal to the superior temporal areas than those with EOD. Because previous studies revealed that attenuation of increases in oxy-Hb in major depression is most clearly and commonly found in the anterior medial portion of frontal cortex, [23][24][25][26] it has been speculated that EOD and LOD exhibit indistinguishable impairment of medial frontal functions. Higher age of onset, rather than longer duration of illness or a large number of episodes, is linked with functional impairment in the lateral prefrontal to temporal areas of the cortex.…”

Section: Discussionmentioning

confidence: 99%

“…This procedure has been widely used for the Japanese WFT paradigm in NIRS experiments. [23][24][25][26] …”

Section: Taskmentioning

confidence: 99%

“…Using NIRS, several studies have demonstrated clear hypofrontality in major depression during engagement in cognitive tasks, among which the phonemic word fluency task (WFT) has been used most frequently. [23][24][25][26] Matsuo et al 27 examined LOD patients in remission using NIRS. Activation of the prefrontal cortex during a cognitive task was significantly less in patients compared with controls, although task performance did not differ significantly between the two groups.…”

Section: Introductionmentioning

confidence: 99%

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Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Background: Individuals with late-life depression can be divided into two categories, those with early and late-onset depression (EOD and LOD, respectively). It has been reported that LOD has more accentuated subcortical vascular lesions and frontal lobe dysfunction (hypofrontality). The aim of the present study was to examine whether LOD exhibits more prominent hypofrontality than EOD during performance of the word fluency task (WFT) under multichannel near-infrared spectroscopy (NIRS), a newly developed non-invasive functional neuroimaging technique. Methods: Eleven patients with EOD, 12 patients with LOD, and 13 healthy controls participated in the study. Clinical symptoms of depression were equivalent in the EOD and LOD groups. Brain magnetic resonance imaging demonstrated more robust subcortical vascular changes in LOD than EOD. The NIRS images were obtained using an ETG-4000, 52-channel NIRS system (Hitachi Medical, Tokyo, Japan). Mean changes in oxy-hemoglobin (oxy-Hb) were evaluated while the participants performed the phonemic WFT. Results: Healthy controls exhibited clear increases in oxy-Hb bilaterally throughout the medial to the lateral frontal cortices and the superior temporal areas during the WFT. In contrast, increases in oxy-Hb were mildly attenuated in EOD and severely attenuated in LOD in most channels. Subsequent analyses revealed that increases in oxy-Hb in LOD during the WFT was significantly poorer than in EOD in the left lateral portion of the cortex, including the dorsolateral prefrontal and the superior temporal areas. In addition, significant negative correlations were obtained between the age of onset and oxy-Hb, as well as between subcortical vascular changes and oxy-Hb in the lateral channels. These findings suggest that the higher the age of onset of depression, and the more prominent the vascular lesions, the greater the attenuation in lateral frontal and temporal activation, as indicated by NIRS. Conclusions: Multichannel NIRS is useful for demonstrating attenuated functional activation in the left lateral prefrontal and temporal areas in LOD and, thus, for differentiating between LOD and EOD. The NIRS findings observed may have useful clinical implications for treatment-resistant LOD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…This procedure has been widely used for the Japanese WFT paradigm in NIRS experiments. [23][24][25][26] …”

Section: Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Impaired response inhibition is associated with self‐reported symptoms of depression, anxiety, and ADHD in femaleFMR1premutation carriers

Kraan

Hocking

Georgiou‐Karistianis

et al. 2013

American J of Med Genetics Pt B

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Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age-and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on selfreported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7%;

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The Impact of Anxiety on Decision Making in Individuals with Intellectual and Developmental Disabilities or a Diagnosis on the Autism Spectrum

Adams

Malone

2021

Decision Making by Individuals With Intellectual and Developmental Disabilities

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Hypofrontality in panic disorder and major depressive disorder assessed by multi-channel near-infrared spectroscopy

Abstract: This study clarified that hypofrontality in panic disorder is evident even with neutral stimuli of little emotional load.

Cited by 77 publications

References 27 publications

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

Impaired response inhibition is associated with self‐reported symptoms of depression, anxiety, and ADHD in femaleFMR1premutation carriers

The Impact of Anxiety on Decision Making in Individuals with Intellectual and Developmental Disabilities or a Diagnosis on the Autism Spectrum

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