Hypofrontality and microvascular dysregulation in remitted late-onset depression assessed by functional near-infrared spectroscopy

Matsuo, Koji; Onodera, Yasuyuki; Hamamoto, Taku; Muraki, Kenro; Kato, Nobuo; Kato, Takeshi

doi:10.1016/j.neuroimage.2005.01.024

Cited by 103 publications

(68 citation statements)

References 73 publications

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“…This hypothesis is strongly supported by the findings of the present study, because vascular lesions as measured by MRI had a negative impact on oxy-Hb in the left prefrontal cortex (CH30, 40, and 50). The present findings are consistent with those of Matsuo et al,27 in that in the latter study LOD patients in remission exhibited less activation in the prefrontal cortex than normal controls and negative correlations were obtained between reduced prefrontal activation and the severity of PVH. Prefrontal microvascular dysregulation as demonstrated by NIRS appears to play a role in the pathophysiology of functional hypofrontality in LOD.…”

Section: Discussionsupporting

confidence: 94%

“…Heterogeneous mechanisms have been hypothesized regarding the pathophysiology of 'vascular depression': 16,17,37 subcortical DWMH may lead to immediate dysfunction of directly connected portions of prefrontal cortex, 38 or breakdown of circuitry between the prefrontal cortex and the basal ganglia, specifically the cortico-striatopallido-thalamo-cortical pathway, may result in dysregulation of mood and emotion. 39 Either hypothesis may account for the frontal cortical dysfunction revealed by the present and previous 27,36 studies.…”

Section: Discussionmentioning

confidence: 75%

“…Activation of the prefrontal cortex during a cognitive task was significantly less in patients compared with controls, although task performance did not differ significantly between the two groups. The LOD patients in the study of Matsuo et al 27 also exhibited a tendency towards a negative correlation between a reduction of prefrontal activation and the severity of periventricular hyperintensity (PVH). These authors concluded that prefrontal microvascular dysregulation, as demonstrated by NIRS, plays a role in the pathophysiology of functional hypofrontality in LOD.…”

Section: Introductionmentioning

confidence: 92%

“…These authors concluded that prefrontal microvascular dysregulation, as demonstrated by NIRS, plays a role in the pathophysiology of functional hypofrontality in LOD. Because Matsuo et al 27 only examined LOD and not EOD patients, the question addressed in the present study was whether NIRS can reveal any differences in the pattern of brain dysfunction between patients with EOD and those with LOD. On the one hand, because the results of a number of MRI and SPECT studies have suggested the existence of subcortical vascular lesions in LOD, it is possible that NIRS will reveal more marked findings in brain pathology or hypofrontality in LOD than in EOD.…”

Section: Introductionmentioning

confidence: 99%

“…Using NIRS, several studies have demonstrated clear hypofrontality in major depression during engagement in cognitive tasks, among which the phonemic word fluency task (WFT) has been used most frequently. [23][24][25][26] Matsuo et al 27 examined LOD patients in remission using NIRS. Activation of the prefrontal cortex during a cognitive task was significantly less in patients compared with controls, although task performance did not differ significantly between the two groups.…”

Section: Introductionmentioning

confidence: 99%

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Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Background: Individuals with late-life depression can be divided into two categories, those with early and late-onset depression (EOD and LOD, respectively). It has been reported that LOD has more accentuated subcortical vascular lesions and frontal lobe dysfunction (hypofrontality). The aim of the present study was to examine whether LOD exhibits more prominent hypofrontality than EOD during performance of the word fluency task (WFT) under multichannel near-infrared spectroscopy (NIRS), a newly developed non-invasive functional neuroimaging technique. Methods: Eleven patients with EOD, 12 patients with LOD, and 13 healthy controls participated in the study. Clinical symptoms of depression were equivalent in the EOD and LOD groups. Brain magnetic resonance imaging demonstrated more robust subcortical vascular changes in LOD than EOD. The NIRS images were obtained using an ETG-4000, 52-channel NIRS system (Hitachi Medical, Tokyo, Japan). Mean changes in oxy-hemoglobin (oxy-Hb) were evaluated while the participants performed the phonemic WFT. Results: Healthy controls exhibited clear increases in oxy-Hb bilaterally throughout the medial to the lateral frontal cortices and the superior temporal areas during the WFT. In contrast, increases in oxy-Hb were mildly attenuated in EOD and severely attenuated in LOD in most channels. Subsequent analyses revealed that increases in oxy-Hb in LOD during the WFT was significantly poorer than in EOD in the left lateral portion of the cortex, including the dorsolateral prefrontal and the superior temporal areas. In addition, significant negative correlations were obtained between the age of onset and oxy-Hb, as well as between subcortical vascular changes and oxy-Hb in the lateral channels. These findings suggest that the higher the age of onset of depression, and the more prominent the vascular lesions, the greater the attenuation in lateral frontal and temporal activation, as indicated by NIRS. Conclusions: Multichannel NIRS is useful for demonstrating attenuated functional activation in the left lateral prefrontal and temporal areas in LOD and, thus, for differentiating between LOD and EOD. The NIRS findings observed may have useful clinical implications for treatment-resistant LOD.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Event‐related functional near‐infrared spectroscopy (fNIRS) based on craniocerebral correlations: Reproducibility of activation?

Plichta¹,

Herrmann²,

Baehne³

et al. 2006

Human Brain Mapping

106

116

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The purpose of the present study was to assess the retest reliability of cortical activation detected by event-related functional near-infrared spectroscopy (fNIRS) based on craniocerebral correlations. Isolated functional activation was evoked in the motor cortex by a periodically performed finger-tapping task. During 44-channel fNIRS recording, 12 subjects performed 30 trials of right and left index finger tapping in two sessions. The retest interval was set to 3 weeks. Simple correlations of the contrast t-values supplemented by scatterplots, channel-wise intraclass correlation coefficients (ICC), as well as reproducibility indices for the size and the location of the detected activation were calculated. The results at the group level showed sufficient single measure ICCs (up to 0.80) and excellent reproducibility of the size and the location (up to 89% were reproducible). Comparisons of the intersession group amplitudes demonstrate that the fNIRS signals were stable across time in a retest study design: the number of significant differences was less than randomly occurring false-positive activated channels if an alpha level of 5% is chosen. Effect size analyses indicated that the intersession amplitude differences are small (mean < 0.25). For deoxyhemoglobin and oxyhemoglobin distinct statistical power profiles were revealed regarding the activation vs. baseline contrast as well as the intersession amplitude differences, indicating a higher sensitivity of deoxyhemoglobin for local hemodynamic changes. The results suggest that sensorimotor activation assessed by event-related fNIRS based on craniocerebral correlations is sufficiently reproducible at the group level.

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Functional Abnormality of the Prefrontal Cortex in Posttraumatic Stress Disorder: Psychophysiology and Treatment Studies Assessed by Near-Infrared Spectroscopy

Ohtani

Matsuo

2006

PTSD

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Hypofrontality and microvascular dysregulation in remitted late-onset depression assessed by functional near-infrared spectroscopy

Cited by 103 publications

References 73 publications

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

Event‐related functional near‐infrared spectroscopy (fNIRS) based on craniocerebral correlations: Reproducibility of activation?

Functional Abnormality of the Prefrontal Cortex in Posttraumatic Stress Disorder: Psychophysiology and Treatment Studies Assessed by Near-Infrared Spectroscopy

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