Hypofractionnement à visée curative dans le cancer de la prostate

Improved Functionality of the Vasculature during Conventionally Fractionated Radiation Therapy of Prostate Cancer

“…Furthermore, our results suggest that during CFRT, stabilization of vessels is necessary so that the 2 nd week fractions become more efficient. While there is increasing interest in high-dose hypofractionated protocols, especially in prostate cancer patients [40], these data raise the question whether such protocols preserve the advantage of increasing oxygen levels and thereby the therapeutic index [41]. In other tumor models however, hypofractionated (3 Gy/fraction radiotherapy) improved oxygenation only during the early phase of the treatment, but led to a considerable decrease of tumor oxygenation in the later phase of irradiation (> 45 Gy) [42].…”

Moderately hypofractionated prostate external-beam radiotherapy: an emerging standard

“…52 This has led to national recommendations in the United Kingdom to embrace this technique and should lead to further confidence in the wider use of hypofractionated prostate radiotherapy. 53 A different approach is the use heavy ions such as protons to both reduce dose to the rectum as well as lower the integral dose, with promising low toxicity results reported in large institutional series. 54 Imaging Advancing imaging capabilities are transforming the practice of prostate radiotherapy.…”

Radiothérapie chez la personne âgée, recommandations pour la pratique clinique pour les principales localisations : cancers du sein, de la prostate et gynécologiques

“…Une application stricte des contraintes de dose, en particulier rectales, est de mise chez le patient âgé. L'irradiation hypofractionnée n'est pour l'instant pas un standard thérapeutique [53].…”