2015
DOI: 10.1016/j.jad.2014.09.034
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Hypoesthesia of the malleolus as a soft sign in depression

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Cited by 3 publications
(3 citation statements)
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“…Our study demonstrates that hypoesthesia is present in anxiety disorders and not only in affective disorders. 9 Furthermore, we can add to the hypotheses proposed by López-Ibor 7 and Rojo-Sierra 8 that both people with anxiety disorders and with "anguish" exhibit hypoesthesia. Although this study has not tested whether the thalamus is the substrate of hypoesthesia, neurobiological abnormalities in the thalamus have been implicated in the pathogenesis of anxiety disorders.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…Our study demonstrates that hypoesthesia is present in anxiety disorders and not only in affective disorders. 9 Furthermore, we can add to the hypotheses proposed by López-Ibor 7 and Rojo-Sierra 8 that both people with anxiety disorders and with "anguish" exhibit hypoesthesia. Although this study has not tested whether the thalamus is the substrate of hypoesthesia, neurobiological abnormalities in the thalamus have been implicated in the pathogenesis of anxiety disorders.…”
Section: Discussionmentioning
confidence: 87%
“…8 A recent study showed that individuals with depression who exhibited malleolar hypoesthesia had greater symptoms of anxiety depression. 9 However, these patients showed depressive disorder. Thus, the relationship between anxiety disorders and hypoesthesia remains unknown.…”
mentioning
confidence: 93%
“…Evidence has suggested that hypoesthesia of the malleolus (i.e., reduced sense of touch on the bony projections on the ankle) may be a soft neurological sign associated with MDD (Livianos et al, 2015). However, other studies have failed to identify significant differences in soft neurological signs between individuals with MDD and healthy controls using standard soft sign assessments, including motor coordination, sensory integration, and disinhibition (Zhao et al, 2013).…”
Section: Soft Neurological Signs Associated With Mddmentioning
confidence: 99%