Hypocholesterolemic Effect of Soybean Protein in Rats and Mice after Peptic Digestion

Yashiro, Akiko; Oda, Shinobu; Sugano, Michihiro

doi:10.1093/jn/115.10.1325

Cited by 56 publications

(26 citation statements)

References 28 publications

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“…In rabbits, an increased sterol excretion (both neutral and acidic), as well as an increased sterol turnover in plasma (7), have been described. Although it was suggested, based on animal findings, that peptide products from the digestion of soy proteins may increase fecal steroid output (8), our studies on cholesterol turnover and excretion in type II patients treated with the soybean diet, failed to show significant changes either in turnover or in excretion (9).…”

Section: Introductioncontrasting

confidence: 79%

Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.

Lovati¹,

Manzoni²,

Canavesi³

et al. 1987

J. Clin. Invest.

161

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The effect of two diets containing different protein sources (animal vs. soybean) on the low density lipoprotein (LDL) receptor activity was tested in freshly isolated mononuclear cells from 12 individuals with severe type II hyperlipoproteinemia. The two diets, both taken for 4 wk in a crossover design were of otherwise identical composition. During the soybean protein diet period, total cholesterol was reduced by 15.9% and LDLcholesterol by 16.4%. The diet containing animal proteins exerted no significant change in plasma lipid levels vs. the baseline findings. The soybean diet regimen dramatically affected the degradation of LDL by mononuclear cells. Degradation was increased 16-fold vs. the basal activity and 8-fold compared with the standard low lipid diet with animal proteins. There was, however, no clear relationship between the reduction of total and LDL-cholesterolemia and the increased LDL degradation. These findings confirm similar data previously obtained in cholesterol-fed rats and suggest that some factor/s, most likely of a protein nature, may regulate the expression of lipoprotein receptors in peripheral cells, particularly when receptor activity is suppressed by experimental diets and/or spontaneous hypercholesterolemia.

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Section: Introductioncontrasting

confidence: 79%

Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.

Lovati¹,

Manzoni²,

Canavesi³

et al. 1987

J. Clin. Invest.

161

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show abstract

“…The intraluminal theory includes the physicochemical interaction of protein hydroly sates with cholesterol and/or bile acid micelles in the intestine during the course of their luminal absorption (28). Recently, the possible participation of the digestion process in the hypocholesterolemic effect of plant protein has frequently been discussed (29)(30)(31)(32) The postabsorptive theory postulates that plant proteins affect the homeostasis of plasma cholesterol (10,33). One attractive explanation for the hypocholester olemic effect of PTB involves the specific combination of amino acids .…”

Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic effect of phototrophic bacterial cells in rats.

Lee¹,

Kobayashi²,

Yasumoto³

1990

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of diets containing the cells of a phototrophic bacteria (PTB), Rhodopseudomonas capsulate, on lipid metabolism was examined in the serum and liver of rats. Three groups of rats, 5 animals per group, were fed either a diet containing 0.2 or 2.0% PTB cells or a casein-based control diet. Each diet contained 1% cholesterol (CHOL). While serum glucose levels were not significantly different between the control and the PTB groups, total CHOL and triacylglycerol (TG) in the serum were significantly lower in the PTB groups than in the control group (p<0.01). The ratio of serum HDL-CHOL to total serum CHOL was significantly higher in the PTB groups than in the control group (p< 0.01). The 2.0% PTB group had lower hepatic TG (p<0.05) but higher hepatic CHOL (p<0.05) than did the control group. These results indicate that PTB cells contain a factor or factors which affect hepatic metabolism or secretion of CHOL.

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“…The amino acid sequence of proteins could possibly influence their cholesterolemic effect. The event encountered in the intestinal tract, production of specific peptide fractions should be taken into consideration (28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Effects of addition of sulfur-containing amino acids and glycine to soybean protein and casein on serum cholesterol levels of rats.

Tanaka

Sugano

1989

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of the supplementation of methionine (Met) , cystine (Cys), and glycine (Gly) to soybean protein or casein on serum and liver lipid levels were studied in rats. Rats were fed cholesterol-free diets containing 25% soybean protein or casein supplemented with 0.75% Met, 2.5% Gly, or a combination of these two for 4 weeks. The addition of Met to soybean protein caused a significant increase in serum cholesterol and this was slightly ameliorated when Gly was given simultaneously. In rats fed casein diets, serum cholesterol tended to decrease when Gly, or Met and Gly were added. A simultaneous supplementation of Met and Gly to casein resulted in a reduction of hepatic cholesterol. Cystine added at the 0.6% level did not cause demonstrable changes in lipid concentrations except for a drop in serum triglyceride of the casein group . When 2.0 Gly was added to cholesterol-enriched diets containing 20% protein , serum cholesterol decreased significantly only when the protein source was casein and the level attained was comparable to that observed in rats fed soybean protein. Liver cholesterol was also markedly decreased by the addition of Gly to casein. The results suggest a possible role of Gly in the regulation of serum cholesterol levels by dietary protein. Key Words soybean protein, casein, methionine, cystine, glycine , lysine, arginine, serum cholesterol Dietary protein is one of the factors influencing serum cholesterol levels (1-4). The factors responsible for the hypocholesterolemic effect of dietary protein remain unclear. Kritchevsky (5, 6) suggested that the arginine/lysine (Arg/Lys) ratio of dietary protein is an important factor in the regulation of cholesterol metabolism, although several data conflicting with the importance of this ratio are available

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Hypocholesterolemic Effect of Soybean Protein in Rats and Mice after Peptic Digestion

Cited by 56 publications

References 28 publications

Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.

Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.

Hypocholesterolemic effect of phototrophic bacterial cells in rats.

Effects of addition of sulfur-containing amino acids and glycine to soybean protein and casein on serum cholesterol levels of rats.

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