Hypocholesterolemic Effect of Dietary Fiber: Relation to Intestinal Fermentation and Bile Acid Excretion.

Kishimoto, Yuka; Wakabayashi, Shigeru; Aida, Hideo

doi:10.3177/jnsv.41.151

Cited by 53 publications

(30 citation statements)

References 16 publications

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“…At the same time it induces a reduction in the LDL cholesterol level in blood serum. Such a dependence was noted in earlier studies (Kishimoto et al, 1995;Kozera et al, 2006;Hanczakowski et al, 2009). Taking into consideration all these dependencies (i.e.…”

Section: Resultsmentioning

confidence: 47%

Production performance of pigs reared in different systems and fed increased energy content diets with or without green alfalfa

Kozera¹,

Karpiesiuk²,

Bugnacka³

et al. 2016

SA J. An. Sci.

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The objective of this study was to determine the effects of various feeding and housing systems on fattening performance, slaughter value and biochemical serum parameters in growing-finishing pigs. The experimental material comprised 90 growing-finishing pigs, divided into six groups of 15 animals that were diverse in terms of rearing (with or without free access to outdoor runs) and feeding systems (fed increased metabolizable energy (ME) content diets with or without green alfalfa). Different feeding regimes and rearing systems had no significant effects on most fattening results and the carcass traits of the pigs except for daily water and diet intake and feed/gain ratio. Daily water intake was lower in pigs fed complete diets plus green alfalfa forage. Low-density lipoprotein (LDL) cholesterol concentrations were statistically lower in the blood serum of Groups 3 and 6 than in Groups 2 and 4. High-density lipoprotein (HDL) cholesterol levels were significantly higher in the serum of Group 6, compared with other groups. Group 3 had significantly higher triglycerides levels compared with Groups 1, 2, 4, 5 and 6. Taking into consideration all these dependencies, it could be assumed that feeding regime and rearing with access to outdoor runs might improve not only blood lipid profile, but also the dietetic value of pork. It seems that feeding a complete diet with increased ME, plus green alfalfa forage and rearing indoors with free access to outdoor runs, gave the best results. ______________________________________________________________________________________

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Section: Resultsmentioning

confidence: 47%

Production performance of pigs reared in different systems and fed increased energy content diets with or without green alfalfa

Kozera¹,

Karpiesiuk²,

Bugnacka³

et al. 2016

SA J. An. Sci.

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“…Soluble fibers reduce the levels of blood cholesterol by 5 to 15% in experimental animals and in humans (14,15) through a number of mechanisms. However, it is improbable that soluble fiber is the main hypocholesterolemic component of S. melongena infusions, since the amount of dietary fiber needed for this effect is 15 to 30 g/ day (16) and the amount present in 10 g of powder (the quantity used to prepare the infusion) was only 1.3 g. Antioxidants such as vitamin C (ascorbic acid) and phenols have received some credit as preventive agents of atherosclerosis (17,18) but their action in reducing plasma cholesterol levels has been seldom described (18).…”

Section: Discussionmentioning

confidence: 99%

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Guimarães

Galvão

Batista

et al. 2000

Braz J Med Biol Res

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Eggplant (Solanum melongena) is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra-or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).

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“…11 The reduction of chilomicron remnant will decrease VLDL synthesis, and so to reduction of VLDL conversion to LDL. 9,10 On the other hand, PS has several mechanisms in lowering LDL cholesterol levels. 12 The most important mechanism was PS as a ligand for LXR -RXR nuclear reseptor.…”

Section: Discussionmentioning

confidence: 99%

“…The major effect of ID as soluble fiber is through the reduction in intrahepatic cholesterol due to the conversion of cholesterol to bile acid. 10 Soluble fiber disturbs the enterohepatic circulation by binding bile acid and cholesterol in the lumen of intestine and then excreted in the stool 9,10 Thus resulting in the reduction of intrahepatic cholesterol concentration, substantially stimulating HMG CoA reductase and CYP 7 activity to increase the compensatory cholesterol and bile acid synthesis. Reduction of intrahepatic cholesterol concentration will increase the synthesis of LDL receptor.…”

Section: Discussionmentioning

confidence: 99%

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The effect of indigestible dextrin and phytosterol on serum LDL-cholesterol level on hypercholesterolemic subjects

Then¹,

Bardosono²,

Harahap³

2009

Med J Indones

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Abstrak AbstractAim To investigate the effects of indigestible dextrin 2x2.3g/day and phytosterol 2x0.6g/day provided for 6 weeks in lowering serum LDL-cholesterol levels amongs hypercholesterolemic subjects.Methods A randomized clinical trial, two pararel groups, double blinded and randomly assigned to each different group was done in 16 subjects per-group.Results Before the, intervention the level of LDL cholesterol of both ID and FS group were 158.81 ± 17.74 mg/dL and 176.18 ± 25.31 mg/dL, respectively. After the intervention there was a significant reduction in LDL cholesterol level in both groups, i.e. among the ID group by 20.93 ± 12.65 mg/dL (13.24%) with p value of <0.001, while the reduction of LDL cholesterol level among the PS group was 21.87 ± 28.76 mg/dL (11.21%) with p value of 0.008. However, the reduction of cholesterol level between the two groups did not show any significant difference. ConclusionConsuming indigestible dextrin 2x2.3g/day and 2x0.6g/day phytosterol (PS) for 6 weeks will have the same ability to decrease the serum cholesterol level in hypercholesterolemic subjects. (Med J Indones 2009; 18: 114-9)

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Hypocholesterolemic Effect of Dietary Fiber: Relation to Intestinal Fermentation and Bile Acid Excretion.

Cited by 53 publications

References 16 publications

Production performance of pigs reared in different systems and fed increased energy content diets with or without green alfalfa

Production performance of pigs reared in different systems and fed increased energy content diets with or without green alfalfa

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

The effect of indigestible dextrin and phytosterol on serum LDL-cholesterol level on hypercholesterolemic subjects

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