Hypochlorous acid gel technology—Its impact on postprocedure treatment and scar prevention

Gold, Michael H.; Andriessen, Anneke; Dayan, Steven H.; Fabi, Sabrina G.; Lorenc, Z. Paul; Berg, Meagan-Helen Henderson

doi:10.1111/jocd.12330

Cited by 21 publications

(33 citation statements)

References 16 publications

(46 reference statements)

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“…26 The benefits of the silicone gels, associated with the anti-inflammatory and biocide effect of the HOCl, has led some authors to consider this as an interesting option to be employed in different phases of the wound healing, from wounds to scars. 24 Scars with greater degree of hypertrophy, might benefit from greater occlusion, better achieved by means of a silicone dressing, while sterile gels are to be used in postoperative care, ulcerated or facial scars. The development of new formulations that combine an absence of tissue toxicity and the prevention of HS are welcomed, still to be tested in multicenter, randomized studies to compare the several presentations of silicones.…”

Section: Discussionmentioning

confidence: 99%

“…The development of new formulations that combine an absence of tissue toxicity and the prevention of HS are welcomed, still to be tested in multicenter, randomized studies to compare the several presentations of silicones. 24…”

Section: Discussionmentioning

confidence: 99%

“…24 The neutral solution of the HA helps disinfect the skin, 19 and is similar to the one released by human cells. 24 A randomized study compared the efficacy of Celacyn with a 100% silicone gel (Kelo-Cote) in the treatment of 42 keloids and HS for 8 weeks. 25 The IGA (Investigator Global Assessment) of efficacy was good/very good in 30% of patients in the Celacyn group at day 56% and 55% at day 112% vs 27.8% at both time points for patients in Kelo-cote group.…”

Section: Hypochlorous Acidmentioning

confidence: 99%

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Silicone sheets and new gels to treat hypertrophic scars and keloids: A short review

Oliveira¹,

Gold

2020

Dermatologic Therapy

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Silicone dressings have been used to treat hypertrophic scars and keloids since 1983. This treatment modality is considered to be safe and efficacious, leading to a progressive improvement in scar color, size, erythema, pliability, pain, and itching. Its mechanism of action is due to the hydration of the skin corneal layer; and modulating the cell signaling between fibroblasts and keratinocytes, mediated by cytokines. Silicone dressings are considered first line treatments for hypertrophic scars and keloids. Silicone gels were developed later, in order to help treating those scars in areas such as the scalp or joints, where fixing the silicone sheets would be a more difficult task, or on the face, where a silicone dressing would be cosmetically undesirable to most. Similar to silicone sheets, silicone gels have also proved to help treating and preventing hypertrophic scars and keloids. A new silicone gel combined with hypochlorous acid has recently been developed to help in treating scars. Hypochlorous acid acts as a biocide and anti‐inflammatory agent, therefore, it has also been used in post procedure, on recent traumatic scars or on nonepithelized skin. This manuscript reviews the use of silicone dressings, silicone gels, and combined gels to treat scars.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Hypochlorous Acidmentioning

confidence: 99%

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Silicone sheets and new gels to treat hypertrophic scars and keloids: A short review

Oliveira¹,

Gold

2020

Dermatologic Therapy

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“…Kwas podchlorawy jest naturalną substancją wytwarzaną przez układ odpornościowy człowieka, produkowaną w makrofagach w trakcie fagocytozy w celu eliminacji bakterii przez neutrofile [4, 9,10]. Działanie środków zawierających kwas podchlorawy polega na denaturacji oraz zwiększeniu przepuszczalności ściany komórkowej mikroorganizmów i w efekcie zniszczeniu komórek bakterii [4].…”

Section: Wstępunclassified

Hypochlorites in the treatment of chronic wounds

Dzikowska¹,

Wojtas²,

Kózka³

2020

Medicine

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Streszczenie:W leczeniu ran odleżynowych stosuje się różne środki, które zarówno oczyszczają ranę, jak i wspomagają ziarninowanie oraz naskórkowanie. W piśmiennictwie naukowym zauważa się skuteczność podchlorynów w gojeniu się ran. Celem pracy była ocena płynu do płukania ran Microdacyn i żelu Microdacyn Hydrogel, stosowanych w leczeniu ran odleżynowych u dwóch osób hospitalizowanych na oddziale leczenia zachowawczego. Badania przeprowadzono na podstawie opisu przypadków pacjenta i pacjentki leczonych na Oddziale Chorób Wewnętrznych i Alergologii Szpitala Specjalistycznego im. J. Dietla w Krakowie w 2014 roku. W badaniach stosowano następujące narzędzia: autorski kwestionariusz ankiety, klasyfikację odleżyn według Thorrance'a, "kolorowy" system klasyfikacji ran przewlekłych, ADL, BMI, AMTS. W wyniku podejmowanych działań zgodnie z koncepcją TIME oraz zastosowania preparatu Microdacyn uzyskano oczyszczenie rany w obu przypadkach. Kolejny etap leczenia, czyli proces ziarninowania i naskórkowania, miał pomyślny przebieg u jednej osoby, u której było możliwe zastosowanie opatrunku hydrokoloidowego (Hydrocoll). Abstract:Different medicaments are used in decubitus ulcer treatment. They enable cleaning the wound and support growth of granulation tissue and epidermization. Scientific literature proves the effectiveness of hypochlorites in the above mentioned processes of wound healing. The aim of the study was to assess the use of Microdacyn liquid for rinsing wounds and Microdacyn gel in decubitus ulcer treatment in two hospitalized patients on a conservative treatment ward. The research was based on the description of the cases of male and female patients hospitalized at Internal Medicine and Allergology Department of J. Dietl Specialist Hospital in Kraków in 2014. The following tools were used: author's questionnaire, Torrance scale for ulcer's degree assessment, "colourful" classification system for long-lasting wounds, ADL scale, BMI index and AMTS. As a result of activities according to the TIME concept, the wounds were cleaned with Microdacyn in both cases. A visible process of growth of granulation tissue and epidermisation as a next step of treatment was achieved for one patient, for whom it was possible to apply hydrocolloid dressing (Hydrocoll).

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“…Cellular death is attributed to the disruption of bacterial adenosine triphosphate (ATP) production by oxidative and fermentative pathways by HClO [ 20 ]. EO water is effective against a wide range of microorganisms and it is used for many applications in medical devices such as root canal irrigation [ 21 ], scar prevention [ 22 ], wound biofilms [ 23 ], and inflammatory skin disorders [ 24 ]. The antiplaque effect [ 25 ] and bacterial viability [ 26 ] of hypochlorous acid mouthwash have been investigated; while the effects of contact time and dose dependent toxicity study have been left neglected.…”

Section: Introductionmentioning

confidence: 99%

The In Vivo Toxicity and Antimicrobial Properties for Electrolyzed Oxidizing (EO) Water-Based Mouthwashes

et al. 2020

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The objective of this study was to verify the feasibility of electrolyzed oxidizing (EO) water as a mouthwash through the evaluation of its in vivo toxicity by embryonic zebrafish and antimicrobial efficacy against Streptococcus mutans (S. mutans). Methodology: Each 1.5–3.0 g of sodium chloride (NaCl), sodium bromide (NaBr), or calcium chloride (CaCl2) were added into an electrolyzer with 300 mL of DD water to produce electrolyzed oxidizing (EO) water. A zebrafish embryo assay was used to evaluate acute toxicity of specimens. Antimicrobial property was conducted with 100 μL microbial count of 1 × 108 cfu/mL S. mutans to blend with each 10 mL specimen of chlorhexidine (CHX) gluconate or hypochlorous acid (HOCl) for various time points. The concentration of viable microorganisms was assessed according to individually standardized inoculum by a plate-count method. Results: Among the EO water produced from NaCl, NaBr, and CaCl2, the EO water from NaCl showed a relatively low mortality rate of zebrafish embryos and was chosen for a detailed investigation. The mortality rates for the groups treated with EO water containing 0.0125% and 0.0250% HOCl were not statically different from those of a negative control, however the mortality rate was 66.7 ± 26.2% in 0.2% CHX gluconate for the same treatment time of 0.5 min. All of the HOCl or 2.0% CHX gluconate groups showed >99.9% antimicrobial effectiveness against S. mutans; while the 0.2% CHX gluconate group showed a bacterial reduction rate of 87.5% and 97.1% for treatment times of 0.5 min and 1.0 min, respectively. Conclusions: Except for the 0.2% CHX gluconate, all the HOCl specimens and 2.0% CHX gluconate revealed similar antimicrobial properties (>99.9%) against S. mutans. The EO water comprised of both 0.0125% and 0.0250% HOCl showed >99.9% antimicrobial efficacy but with little in vivo toxicity, illuminating the possibility as an alternative mouthwash for dental and oral care.

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Hypochlorous acid gel technology—Its impact on postprocedure treatment and scar prevention

Abstract: A postprocedure regime using this technology, aimed at preventing infection, reducing inflammation, and promoting healing is proposed to have benefits over current regimes as it appears to be effective, safe, and well tolerated.

Cited by 21 publications

References 16 publications

Silicone sheets and new gels to treat hypertrophic scars and keloids: A short review

Silicone sheets and new gels to treat hypertrophic scars and keloids: A short review

Hypochlorites in the treatment of chronic wounds

The In Vivo Toxicity and Antimicrobial Properties for Electrolyzed Oxidizing (EO) Water-Based Mouthwashes

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