Hypochlorous acid antiseptic washout improves patient comfort after intravitreal injection: A patient reported outcomes study

Fam, Anthony; Finger, Paul T.; Tomar, Ankit Singh; Garg, Gaurav; Chin, Kimberly J.

doi:10.4103/ijo.ijo_2001_20

“…Additionally, compared with the traditional application of 50% TTO treatment for 3 months in a row, we found that there was no only obvious differentiation between them ( Demodex mite eradication rate between the two groups at the 55 th day) ( ∗∗ p = 0.006 < 0.01) ( Figure 3 ) with regard to the average Demodex figures, but the successful killing rate is higher at different check points of this clinic trail in HOCL groups than that of control ( ∗ p 15 th vs. 1 st day = 0.028 < 0.05; ∗∗ p 30 th vs. 1 st day = 0.002 < 0.01; ∗∗ p 55 th vs. 1 st day = 0.0018 < 0.01) ( Figure 3 ). The HOCL is a natural immunity reaction of the human body; our data shows no discomforts which coincide with previous study [ 12 , 14 , 44 , 51 ]. Otherwise, many discomforts such as allergic reactions, contact dermatitis, and ocular irritations are well-known adverse reactions of TTO proposal [ 54 ].…”

Section: Discussionsupporting

confidence: 92%

“…Observed were then followed a medication box labelled with a bunch of number which contained all medicaments. The clinical research group used market-oriented available HOCL 0.01% pH 5.4 (20 mL) (Avenova®, NovaBay Pharmaceuticals, Inc., Emeryville, California, USA) [ 14 ]. At the same time, the control was treated with a placebo material 0.1% Purified Sodium Hyaluronate (20 mL) (Santen Pharmaceutical Co. Ltd.) which is a 0.72% (g/mL) sodium chloride solution with the osmotic pressure of 235 mOsmol/kg and a pH value of 6.5.…”

Section: Participants and Evaluationsmentioning

confidence: 99%

Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization

Li

¹

,

Wang

²

,

Mo

³

et al. 2022

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Background. Dry eye is a multifactor disease which needs comprehensive treatments to keep the homeostasis of ocular surface. Objective. To explore the effect of hypochlorous acid on the meibomian gland dysfunction dry eye through ultrasonic atomization. Methods. We set this study of 0.01% HOCL and 0.1% hyaluronate by ultrasonic atomization. All the data was recorded at the 1st, 15th, 30th, and 55th days. The patients’ complains, the meibum analysis, conjunctive congestion, corneal staining, Schirmer’s I test, and NIBUT were recorded by K5M, the MMP-9, and IL-2 of tear by inflammation kit; the Demodex was recorded by microscopy. Results. 53 patients have joined this study. There is no statistic difference between them on OSDI (day 15: p = 0.061 , 30: p = 0.055 , 55: p = 0.052 ); results show the 10.57 ± 0.13 and 12.54 ± 0.17 reduction on OSDI; the differences of both treatments are significant ( ∗ ∗ p < 0.01 ). Increased Schirmer’s and TBUT are 3.27 ± 0.10 and 6.29 ± 0.10 ( ∗ ∗ p < 0.01 ) or 7.32 ± 1.72 s and 9.22 ± 1.41 s ( ∗ p < 0.05 ); the decreased conjunctive and corneal staining are 0.23 ± 0.07 and 0.45 ± 0.06 ( ∗ ∗ p < 0.01 ) or 0.42 ± 0.03 and 0.37 ± 0.02 ( ∗ p < 0.05 ) at both groups. The differences of MMP-9 and IL-2 negative rate are significant ( Z = 0.896 , ∗ ∗ p = 0.002 < 0.01 ; Z = 0.659 , ∗ ∗ p = 0.001 < 0.01 ); the number of Demodex mites at first is 10 or 11, while the last is 2 or 6 ( Z = − 4.642 , ∗ ∗ p < 0.01 ; Z = 2.742 , p > 0.05 ). The Demodex count between them is significant ( Z = − 2.310 , ∗ p = 0.032 < 0.05 ). The survival times (ST) of each stage at the HOCL are 110.75 ( 108.50 ± 24.50 ), 95.50 ( 90.25 ± 14.50 ), and 75.25 ( 73.48 ± 8.50 ) min which are shorter than those of control which are 155.50 ( 160.10 ± 21.50 ), 130.25 ( 128.25 ± 16.50 ), and 105.75 ( 102.50 ± 14.50 ) min ( ∗ ∗ p < 0.01 ). The Demodex eradication rate of HOCL is statistic significant ( ∗ p 15th vs. 1st day = 0.028 < 0.05 ; ∗ ∗ p 30th vs. 1st day = 0.002 < 0.01 ; ∗ ∗ p 55th vs. 1st day = 0.0018 < 0.01 ). Conclusions. 0.01% HOCL improves the Demodex eradication by shortening the survival time; the HOCL acts on the ocular surface by reducing the inflammation. The ultrasonic atomization helps for the drug usage.

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“…Our results show that there is a statistically significant improvement in OSDI scores in the HOCL group, with a reduction of 20.3 ± 20 scores, while there is only a reduction of 9.6 ± 15.3 score in the control group. These results are in agreements with previous studies, whereby topical 0.01% HOCL spray after intravitreal injection effectively improves patients' quality of life [37]. The effect of 0.01% HOCL has also been identified in dry eye patients, which results in a relief of symptoms over a 30 day period of use [38].…”

Section: Discussionsupporting

confidence: 91%

Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial

Zhang

¹

,

Wu

²

,

Wan

³

et al. 2023

JCM

2

0

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Purpose: To evaluate the efficacy and safety of eyelid hygiene using topical 0.01% hypochlorous acid (HOCL) through ultrasonic atomization after 2 weeks in patients with blepharitis. Design: Randomized controlled trial. Methods: Patients with blepharitis were randomized into two groups: topical 0.01% HOCL through ultrasonic atomization (HOCL group, 42 eyes) or eyelid scrubs (control group, 37 eyes). Patients in both groups received warm compresses twice daily and topical 0.5% levofloxacin three times a day. Primary outcomes were the ocular surface disease index scores (OSDI), lid margin redness, lid margin abnormalities, meibum expressibility, meibum quality, and noninvasive breakup time after 2 weeks. Secondary outcomes were conjunctiva redness, corneal fluorescein staining, and tear meniscus height. A questionnaire of treatment adherence with a free response section was administered to confirm patient compliance and comments. Results: Sixty-seven participants participated in this study. Both groups show an improvement in all primary outcomes, while statistically significant improvements in OSDI, lid margin redness, lid margin abnormality, meibum expressibility and quality are only limited to the HOCL group after 2 weeks of treatment (p < 0.05, p < 0.05, p < 0.001, p < 0.001 and p < 0.001, respectively). Subgroup analysis in HOCL reveals that only the change in lid margin abnormality and meibum expressibility in the mild–moderate meibomian glands loss patients at baseline has a statistically significant difference p < 0.05). Multiple linear regression shows that the improvement in OSDI is negatively associated with meibum expressibility score at the baseline (95% CI [−28.846, −1.815], p = 0.028). The patient compliance is 7.1 ± 2.0 in the HOCL group and 7.1 ± 1.8 in the control group (p > 0.05). No adverse events are reported. Conclusion: Topical 0.01% HOCL through ultrasonic atomization is a tolerable and effective eyelid hygiene treatment for blepharitis.

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“…(Goto, 2015;Ateş, 2020). As for the usage areas in health services superficial skin infections, acute and chronic wound, antisepsis of the operation site before and after the operation, mastitis, metritis, rhinitis, sinusitis, ocular and oral lesions, skin burns can be exemplify (Hakim et al, 2015;Gray et al, 2016;Karabulut and Gülay, 2016;Fuentes, 2018;Kim and Nam, 2018;Kanclerz et al, 2019;Block and Rowan, 2020;Fam et al, 2020;Gold et al, 2020;Joachim, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

Babur

¹

,

Karademir

²

2023

Turkish JAF Sci.Tech.

0

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Dermatophytosis is a mycotic disease of the skin that is resistant to treatment. The aim of this study was to investigate the treatment efficacy of a novel antimicrobial agent, Hypochlorous Acid (HOCL), on dermatophytosis of cats and dogs, in comparison with Ketaconazole. In this study, a total of 76 animals (26 cats and 50 dogs) without any disease other than skin fungal infection after clinical, hematological, biochemical, microscopic and Wood's lamp examinations were used. Subjects were randomly assigned to two equal treatment groups within their own species as HOCL: HP and Ketaconazole: KT. Naked eye inspection results were collected on the 8th, 11th and 15th days of all patients. The study was terminated on the 15th day by collecting the Wood's lamp and microscopic examination data together with the last inspection finding. Findings were analyzed statistically with chi-square and CART (Classification and Regression Tree) algorithm test. Inspection results of the treatment groups exhibited significant recovery over time (day 8, 11 and 15) for both species (p0.05). According to the microscopic examination results, a significant statistical difference was observed between the HP and KT groups (p0.05). As a result, it was concluded that HOCl has an effect on dermatophytosis of cat and dogs, although not as much as Ketaconazole, but further studies are needed to reveal the results more clearly.

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Hypochlorous acid antiseptic washout improves patient comfort after intravitreal injection: A patient reported outcomes study

Cited by 10 publications

References 36 publications

Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization

Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization

Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

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