Hypocalciuria Can Differentiate Preeclampsia from Chronic Hypertension in the Third Trimester

A systematic review and meta‐analysis of hypocalciuria in pre‐eclampsia

“…Eight of the included studies 10,[13][14][15]19,20,22,26 used a rise in the systolic blood pressure of more than 30 mm Hg or in the diastolic blood pressure of more than 15 mm Hg above baseline as part of their definition of pre-eclampsia. Given that this criterion is not part of current pre-eclampsia definitions, a subgroup analysis was performed comparing studies that used this definition of pre-eclampsia and those that did not.…”

“…The association of hypocalciuria with pre‐eclampsia was first reported in 1984 . Since then, numerous additional publications have concluded that urinary calcium excretion is decreased in patients with pre‐eclampsia. In fact, urinary calcium excretion has been shown to decrease as early as the first trimester among women who subsequently were diagnosed with pre‐eclampsia …”

“…The association of hypocalciuria with pre-eclampsia was first reported in 1984. 6 Since then, numerous additional publications [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] have concluded that urinary calcium excretion is decreased in patients with pre-eclampsia.…”

Calciuria and preeclampsia: A case–control study

“…Al‐Mait et al . compared preeclampsia, chronic hypertension and controls, and found sensitivity, specificity, and positive and negative predictive values of 95, 85, 84, and 96% for calciuria less <175 mg/24 h 36 . In patients who became severe after the initial examinations, calciuria levels ranged from50–137 mg/24 h, values that may be predictors of the disease.…”

“…29 Our finding of 167 mg/24 h, obtained in the same research group, is correlated with published data that show levels from 50-195 mg/24 h, without a definitive cutoff for clinical use. Al-Mait et al compared preeclampsia, chronic hypertension and controls, and found sensitivity, specificity, and positive and negative predictive values of 95, 85, 84, and 96% for calciuria less <175 mg/24 h. 36 In patients who became severe after the initial examinations, calciuria levels ranged from 50-137 mg/24 h, values that may be predictors of the disease. The serum concentration of uric acid decreases during normal pregnancy as a consequence of increased glomerular filtration rate and reduced proximal tubular reabsorption.…”