Hypocalcemia in the Newborn

Jain, Ashish; Agarwal, Ramesh K.; Sankar, M. Jeeva; Deorari, Ashok K.; Paul, Vinod K.

doi:10.1007/s12098-010-0176-0

Cited by 99 publications

(76 citation statements)

References 7 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Preeclampsia, prematurity, perinatal stress/asphyxia, intrauterine growth restriction, infant of diabetic mother, maternal hyperparathyroidism, iatrogenic (alkalosis and use of blood products, diuretic, phototherapy, lipid infusion), maternal intake of anticonvulsants (Phenobarbital ,Phenytoin sodium) are all risk factors for hypocalcemia especially for the early-onset type which presents within 2 -3 days of life (20).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

Mosayebi¹,

Nariman²,

Hosseini³

et al. 2013

J Compr Ped

View full text Add to dashboard Cite

Background: Preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality. Objectives: The aim of this study was to determine the laboratory disorders in neonates born to preeclamptic mothers. Patients and Methods: This descriptive-retrospective study was conducted in the neonatal units of Shahid Beheshti and Shabihkhani Hospitals on neonates born to preeclamptic mothers during 2009 -2012. Neonatal data including gestational age, gender, mode of delivery, birth weight and laboratory reports were extracted from their medical records and analyzed. Results: A total of 2600 newborns were admitted during the study period, of which 84 infants were born to mothers with preeclampsia. The laboratory disorders were neutropenia in 32 cases (37%), anemia in 33 (39.2%), leucopenia in 24 (28.5%), thrombocytopenia in 23 (27.3%), hypoglycemia in 28 (33.3%), hypocalcemia in 22 (26.1%) and hyperbilirubinemia in 33 (39.2%) patients. Thirty one infants (35.6%) had positive cultures .Twenty nine patients (35%) developed coagulative disorders with prolonged PT and PTT. Evaluation of ABG showed 16 infants (19%) with metabolic acidosis, 23 (27.3%) hypoxia and 24 (28.5%) respiratory acidosis cases. All the laboratory abnormalities were more common in preterm and low birth-weight-infants. Conclusions: Early detection and timely management of laboratory disorders in preeclamptic infants may lead to improvement of the neonatal outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

Mosayebi¹,

Nariman²,

Hosseini³

et al. 2013

J Compr Ped

View full text Add to dashboard Cite

show abstract

“…[4][5][6] Another entity, resistant or prolonged hypocalcemia is defined as symptomatic hypocalcemia not responding to appropriate doses of calcium supplementation, calcium requirement beyond 72 h of age in neonates orhypocalcemia manifesting beyond 1st week of life. 1 The index case in this report is of late onset variety.…”

Section: Discussionmentioning

confidence: 89%

“…1 The early NH usually manifests within 72 hours after birth, requiring short term calcium supplementation, and it is a frequent co morbidity in high risk neonates. Maternal diabetes, prematurity and Perinatal asphyxia 1,[4][5][6][7] are the important causes of early NH. Late NH occurs after 1st week of life, usually symptomatic and requires long-term calcium therapy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

Hasina

Hassan²

2017

Bangladesh J Child Health

View full text Add to dashboard Cite

IntroductionNeonatal hypocalcaemia (NH) is a commonly reported metabolic abnormality in neonate. Ionized calcium is vital for various metabolic pathways like blood coagulation, neuronal depolarization, integrity of cell membrane, enzyme catalysis etc. Major part of the body calcium exists in bones and muscles (99%) and the rest of the calcium is present in extracellular fluid (1%). In extracellular fluid about 40% calcium is bound to albumin, another 10% is bound to citrate, phosphorus, lactate and sulfate and the rest (50%) exists as ionized free form, help in metabolic functions. 1,2 Hypocalcaemia has significant negative impact on newborn health. It is defined as total serum calcium of <8 mg/dL (2 mmol/L) or ionized calcium of <1.2 mmol/L in term neonates, and<7 mg/dL (1.75 mmol/L) of total calcium or <4 mg/dL (1 mmol/L) of ionized calcium in preterm infants. 3 Causes of neonatal hypocalcaemia is diverse like prematurity, perinatal asphyxia, cow milk feeding. Maternal Vitamin D deficiency has also been reported as a cause of neonatal hypocalcaemia. We are reporting a case of neonatal hypocalcaemia attributed to maternal Vitamin D deficiency in Asian context. Case Report 9 days old out born boy was admitted in NICU of Apollo Hospitals Dhaka on 3 rd September 2014 with h/o seizures. In immediate neonatal period, in a different hospital where he was born, the baby developed mild transient tachypnoea of newborn which required no active management. He was discharged from that hospital on 3 rd postnatal day. At 7 th day of age he developed convulsion and was re-admitted to that hospital. His convulsion was generalized in nature, 4-5 episodes with duration of approximately 10 seconds each. He was initially treated in that hospital with anticonvulsant, antibiotic and calcium gluconate but as condition was deteriorating, he was transferred to Apollo hospital at 9 th day of age. The pregnancy was unremarkable and the baby was born at term by an uncomplicated caesarian section. His birth weight was 2580 gram (10th to 25th percentile). Mother had bronchial asthma, otherwise family history was noncontributory. There was no history of fever, trauma or sepsis related risk factors. The baby was breastfed and supplemented with formula feed. The baby's weight was 2580gram. He was afebrile with normal vital signs. He had no dysmorphic features and physical examination was otherwise unremarkable. Twenty four hours after admission, the baby developed 2 episodes of focal convulsion for 10 seconds each. A Case of NeonatalInitial blood work showed normal septic screening, renal function and electrolytes with hypocalcemia (total calcium 6 mg/dl (8.5 to 10.5 mg/dl ) and hyperphosphataemia. Blood glucose level was 4.3mmol/L. The diagnosis was revealed after further maternal history and blood tests. On further query, the mother did not take any antenatal vitamin supplements. The baby had not been started on vitamin D supplements.Vitamin D deficiency in the infant was diagnosed on the basis of a low 25-hydroxy vitamin D level at 19 nmol/...

show abstract

“…Premature termination of trans-placental supply, exaggeration of the postnatal drop to hypocalcemic level, increased calcitonin and decrease target organ responsiveness to parathyroid hormone are considered as associated factors. A high percentage of hypocalcemia was detected in premature infants from 28 to 32 gestational weeks (3).…”

Section: Discussionmentioning

confidence: 97%

The Frequency of Early and Late Hypocalcemia Among Hospitalized Newborns in An Iranian Hospital

et al. 2015

View full text Add to dashboard Cite

Background: Hypocalcemia is a common neonatal abnormality particularly in high-risk neonates. Hypocalcaemic neonates with early diagnosis recover after a period of treatment with calcium. Objectives: In this study we aimed to determine the frequency of early and late hypocalcemia, as well as the influence of some relating factors. Patients and Methods: One hundred neonates with early or late hypocalcemia (hospitalized in Aliasghar Hospital of Tehran, Iran, during 2011) were enrolled. The required information was extracted from medical records. The frequency of each hypocalcemia type and relating factors were assessed. Results: Amongst all subjects, 63% had early and 37% had late hypocalcemia. We found significant associations between early or late hypocalcemia with Apgar score of < 5 and prematurity (P < 0.05). Conclusions: Calcium supplemented food could prevent hypocalcemia complications in high-risk neonates.

show abstract

Hypocalcemia in the Newborn

Cited by 99 publications

References 7 publications

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

A Case of Neonatal Hypocalcaemia Due to Maternal Vitamin D Deficiency

The Frequency of Early and Late Hypocalcemia Among Hospitalized Newborns in An Iranian Hospital

Contact Info

Product

Resources

About