Hypocalcaemic chorea secondary to malabsorption

Howdle, P D; Bone, Ian; Losowsky, M. S.

doi:10.1136/pgmj.55.646.560

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…Hypocalcemia has been described to be causative in movement disorders. [3][4][5][6][7] The limitation of the chorea to the right side of the body is consistent with the lack of contralateral cortical input to the basal ganglia as a result of the prior stroke. In this case, the cause of the patient's hemichorea was hypocalcemia secondary to nutritional vitamin D deficiency.…”

Section: Discussionsupporting

confidence: 58%

Nutritional Vitamin D Deficiency Presenting as Hemichorea

2007

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The authors describe a pediatric patient with repaired hypoplastic left heart syndrome developing protein-losing enteropathy, hypocalcemia, vitamin D deficiency, and hemichorea. After correction of nutritional vitamin D deficiency with calcium and vitamin D supplementation, the chorea resolved. Hypoalbuminemia also improved after the correction of vitamin D deficiency without requiring albumin infusions. This report also raises the possible role of calcium or vitamin D in the intestinal loss of albumin in protein-losing enteropathy.

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Section: Discussionsupporting

confidence: 58%

Nutritional Vitamin D Deficiency Presenting as Hemichorea

2007

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“…82 Depending on diet and other homeostatic factors, serum calcium may be low or normal. Other causes of hypocalcemia reported to result in chorea include malabsorption, 83 bisphosphonate therapy, 84 and low vitamin D levels. 85 Hypercalcemia may also cause choreoathetosis but is far less commonly reported in the literature.…”

Section: Infectious/para-infectiousmentioning

confidence: 99%

“…87,88 There can also be a disconnection between the apparent symmetry of the calcification and asymmetry of clinical symptoms. 83,85,[87][88][89] This suggests that the imaging findings may be correlative rather than causative. The threshold for abnormal movements is potentially lowered by the basal ganglia mineralization, causing increased sensitivity to electrolyte disruption.…”

Section: Infectious/para-infectiousmentioning

confidence: 99%

Diagnostic Uncertainties: Chorea

Cincotta

Walker

2023

Semin Neurol

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Chorea is a hyperkinetic movement disorder with a multitude of potential etiologies, both acquired and inherited. Although the differential diagnosis for new-onset chorea is extensive, there are often clues in the history, exam, and basic testing that can help to narrow the options. Evaluation for treatable or reversible causes should take priority, as rapid diagnosis can lead to more favorable outcomes. While Huntington's disease is most common genetic cause of chorea, multiple phenocopies also exist and should be considered if Huntington gene testing is negative. The decision of what additional genetic testing to pursue should be based on both clinical and epidemiological factors. The following review provides an overview of the many possible etiologies as well as a practical approach for a patient presenting with new-onset chorea.

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“…Hypocalcemia as cause of chorea is more commonly seen in hypoparathyroidism, either idiopathic, postoperative, or pseudo-hypoparathyroidism [ 108 ]. Other reported causes of chorea secondary to hypocalcemia include malabsorption or bisphosphonate treatment [ 109 110 111 ]. Chorea is usually generalized and patients may show other manifestations of hypocalcemia.…”

Section: Acquired Choreasmentioning

confidence: 99%

Review of Hereditary and Acquired Rare Choreas

Martínez-Ramírez

Walker

Rodríguez-Violante

et al. 2020

Tremor and Other Hyperkinetic Movements

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The first step in diagnosis is recognizing the movement disorder as chorea [1]. Chorea is characterized by irregu lar, purposeless, arrhythmic, nonstereotyped involuntary movements that flow from one body part to another [2]. These movements can affect any part of the body, although usually brief, can also be of long duration, and can have small or large amplitude. Movements with large amplitude localized proximally in the arms are called "ballismus" [3]. Once the movement disorder has been recognized as chorea, we then recommend classifying the age of onset as either childhood (prior to the age of 16) or adultonset [1]. Multiple causes of chorea exist in both age groups, many of which fit in the definition of rare diseases [4]. Since the most common cause of acute chorea in childhood is Sydenham's chorea and of chronic progressive chorea in adults is Huntington's disease (HD), we recommend these disorders should be tested for, as appropriate, and excluded before proceeding to other diagnostic pathways. The next step is to determine, if possible, whether the chorea is hereditary (genetic) or acquired (nongen etic) in nature. The family history should be carefully and

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Hypocalcaemic chorea secondary to malabsorption

Abstract: Summary A patient presented with chorea and a recent history of Crohn's disease. Investigation revealed the cause of the chorea to be hypocalcaemia secondary to malabsorption. So far as is known there has been no previous report of hypocalcaemic chorea due to malabsorption.

Cited by 11 publications

References 23 publications

Nutritional Vitamin D Deficiency Presenting as Hemichorea

Nutritional Vitamin D Deficiency Presenting as Hemichorea

Diagnostic Uncertainties: Chorea

Review of Hereditary and Acquired Rare Choreas

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