Hypobetalipoproteinemic agents. 3. Variation of the polycyclic portion of 4-(1-adamantyloxy)aniline

Heyd, William E.; Bell, Larry T.; Heystek, J. R.; Schurr, P.E.; Day, Charles

doi:10.1021/jm00351a019

Cited by 6 publications

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“…Heyd et al showed in 1982 that derivatives of 1 and 2 are hypobetalipoproteinemic agents. [162] Upjohn filed patents where aniline derivatives of 1 and 2 are used as "... hypolipidemic agents, particularly hypocholesteremic…". [163] Mobil Oil investigated several different compounds of 1 and 2 for pharmaceutical use and showed that these derivatives "... have antiviral activity against HIV."…”

Section: Applications Of Diamondoidsmentioning

confidence: 99%

Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

2008

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Marilyn Monroe knew that "diamonds are a girl's best friend" but, in the meantime, many chemists have realized that they are also extremely attractive objects in contemporary chemistry. The chemist's diamonds are usually quite small (herein: nanometer-sized "diamondoids") and as a result of their unique structure are unusual chemical building blocks. Since lower diamondoids (up to triamantane) have recently become available in large amounts from petroleum and higher diamondoids (starting from tetramantane) are now also accessible from crude oil new research involving them has begun to emerge. Having well-defined structures makes these cage compounds so special compared to other nanometer-scale diamonds. Selective and high-yielding synthetic approaches to the functionalization of diamondoids gives derivatives that can find applications in, for example, polymers, coating materials, drugs, and molecular electronics.

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Section: Applications Of Diamondoidsmentioning

confidence: 99%

Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

2008

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“…Heyd et al. zeigten 1982, dass Derivate von 1 und 2 gegen Hypobetalipoproteinmangel wirksam sind 162. Die Firma Upjohn reichte mehrere Patente ein, in denen Anilinderivate von 1 und 2 als Wirkstoff gegen Lipidmangel und speziell gegen Cholesterinmangel verwendet wurden 163.…”

Section: Anwendungen Der Diamantoideunclassified

“Diamonds are a chemist's best friend”: die großen Geschwister des Adamantans

2008

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Marilyn Monroe wusste: “Diamonds are a girl's best friend”, aber auch Chemiker haben Diamanten als attraktive Forschungsobjekte entdeckt. Dabei sind diese Diamanten normalerweise recht klein (hier nanometergroße “Diamantoide”) und stellen durch ihre einzigartigen Strukturen äußerst ungewöhnliche Synthesebausteine dar. Da es seit wenigen Jahren möglich ist, die “niederen” Diamantoide (bis zum Triamantan) in großen Mengen aus Erdöl zu erhalten, und da die Isolierung der “höheren” Diamantoide (ab Tetramantan) aus Rohöl ebenfalls technisch machbar ist, stehen diese somit der Forschung zur Verfügung. Die Diamantoide zeichnen sich gegenüber anderen nanometergroßen Diamanten besonders durch ihre klar definierten Strukturen aus. Durch zielgerichtete Funktionalisierungen mit hohen Ausbeuten lassen sich Derivate für sehr unterschiedliche Anwendungen wie z. B. Polymere, Oberflächenbeschichtungen, Medizin, molekulare Elektronik usw. herstellen.

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Medicinal Compounds

2024

The Chemistry of Diamondoids

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Hypobetalipoproteinemic agents. 3. Variation of the polycyclic portion of 4-(1-adamantyloxy)aniline

Abstract: 40 g, 0.22 mol, Pierce Chemical Co.) was converted to the phenol, in 63% yield, in the manner described above: bp 91-93 °C (20 mm); n24D 1.4440 [lit.1 23 bp 92 °C (25 mm); n25D 1.4469].

Cited by 6 publications

References 6 publications

Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

“Diamonds are a chemist's best friend”: die großen Geschwister des Adamantans

Medicinal Compounds

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