Hypoalgesia in genetically hypertensive rats (SHR) is absent in rats with experimental hypertension.

Sitsen, J. M. A.; Jong, W. De

doi:10.1161/01.hyp.5.2.185

Cited by 110 publications

(38 citation statements)

References 16 publications

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“…For example, spontaneously hypertensive rats (SHRs), which have been selectively bred to develop hypertension, demonstrate reduced responsiveness to nociceptive stimuli as early as the third week of life [43,48].…”

Section: Discussionmentioning

confidence: 99%

Maternal family history of hypertension attenuates neonatal pain response

Taddio

Shah

Pagé

et al. 2009

Pain

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Reduced sensitivity to naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension, high-normal blood pressure, and a family history of hypertension. The present study sought to extend these findings by examining the relationship between familial history of hypertension and pain responsivity in neonates. Eighty infants had intramuscular (lM) injections of vitamin K p€r-formed in the delivery room within t h ofbirth as per institutional practice. Video recordings ofthe injection procedure were used by trained observers to code infant pain responses using facial grimacing and cry duration. Prior to the birth ofthe child, the infants'parents each completed a family blood pressure history survey and these responses were used to identifu infants with and without a maternal and paternal family history of hypertension. As compared to infants without a maternal family history of hypertension, infants with a maternal family history of hypertension had significantly shorter crying times, (1,74)=6.96, p=.O'1, q2 =.086, and marginally lower facial grimacing scores, F(1,74)=2.68, p=.16, 42 =.O3s, during vitamin K injection. The presence of attenuated responses to the IM injection in neonates with a maternal family history ofhypertension provides important and novel evidence that reduced pain responding in individuals at risk for hypertension is not a learned response st5de, but rather may arise from prenatal or genetic influences.

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Section: Discussionmentioning

confidence: 99%

Maternal family history of hypertension attenuates neonatal pain response

Taddio

Shah

Pagé

et al. 2009

Pain

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“…Thus, pressor-mediated increases in baroreflex stimulation are frequently offered as a mechanism of hypertensive hypoalgesia~Dworkin, 1988;Ghione, 1996;Maixner, 1991!. Endogenous opioids have also been implicated in this effect, as a number of laboratory animal studies have shown that hypertensive hypoalgesia is reversed by administration of opiate antagonists~Delbarre, Casset-Senon, Delbarre, Sestillange, & Christin, 1982;Saavedra, 1981;Sitsen & de Jong, 1983Wendel & Bennett, 1981!. Other authors have suggested that the arrow of causation is reversed such that, in some cases, hypertension is a consequence of hypoalgesia. As early as 1979, Dworkin and colleagues proposed that blood pressure increases are negatively reinforced by baroreflexmediated dampening of central nervous system responses to aversive events~Dworkin, Filewich, Miller, Craigmyle, & Pickering, 1979!.…”

Section: Theoretical Implications Of Hypertensive Hypoalgesiamentioning

confidence: 99%

“…Consistent with this model, some of the earliest laboratory animal studies of the relationship between hypertension and hypoalgesia indicated that decreased pain perception is not dependent upon high blood pressure. For example, SHR exhibit elevated nociceptive thresholds as early as 4 weeks of age, when their blood pressure levels are not yet significantly different from age-matched controls~Maixner et al., 1982;Sitsen & de Jong, 1983;Wendel & Bennett, 1981!. Further, acute administration of the opiate antagonist naloxone can reverse hypoalgesia in SHR without affecting resting blood pressure~Maix-ner et al, 1982!.…”

Section: Theoretical Implications Of Hypertensive Hypoalgesiamentioning

confidence: 99%

Decreased pain perception and risk for hypertension: Considering a common physiological mechanism

France

1999

Psychophysiol.

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For almost two decades, researchers have demonstrated that hypertension is reliably associated with decreased perception of pain. More recently, a growing body of evidence has begun to suggest that hypoalgesia is not a consequence of high blood pressure, as the phenomenon precedes the onset of hypertension in individuals at risk for the disorder. This article provides a review of empirical evidence of decreased pain perception in normotensive persons with a family history of hypertension, elevated resting blood pressure, or exaggerated cardiovascular reactivity to stress. Based on the existing evidence, hypoalgesia is argued to be a correlate of dysregulation of central nervous system structures involved in both pain control and cardiovascular regulation in individuals who are genetically predisposed to develop high blood pressure. As such, hypoalgesia may serve as a valuable method of identifying individuals at greatest risk for hypertension. Descriptors: Pain, Hypoalgesia, Risk for hypertensionHypertension is often referred to as a "silent" killer because it is typically believed that individuals with high blood pressure rarely experience subjective symptoms of their disorder. In fact, two decades of research has demonstrated convincingly that hypertension is reliably associated with at least one subjective symptomhypoalgesia, or decreased perception of pain. The following article will briefly review the existing literature on the association between hypoalgesia and high blood pressure, and will present evidence to suggest that this relationship may have important clinical and theoretical implications. In particular, evidence of hypoalgesia in normotensive individuals at increased risk for hypertension will be offered in support of the notion that hypertension and decreased pain perception may result from a common physiological dysfunction. Specifically, central opioid hyposensitivity is hypothesized as a mechanism of both hypoalgesia and exaggerated autonomic and neuroendocrine responses to stress in individuals at risk for hypertension. Finally, it will be argued that if hypoalgesia and hypertension share a common pathophysiology, then decreased pain perception might serve as a behavioral marker of risk for hypertension long before the onset of high blood pressure levels.

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“…27 Hypertension-related hypalgesia has been reported in animal and human studies. [28][29][30] Zamir and Shuber 31 showed that there is a significant positive correlation between BP and pain threshold, determined using a pulp tester, which applies a 600 Hz, 0.1 ms monophasic pulse to the tooth pulp, in healthy normotensive and hypertensive volunteers. Falcone et al 32 also demonstrated that the mean dental pain threshold determined by pulp stimulation significantly correlates with mean DBP in hypertensive patients with coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Relationship between base blood pressure during sleep and health-related quality of life in healthy adults

2006

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There are many reports indicating that night time blood pressure (BP) is closely associated with target organ damage. However, BP in the waking period is influenced by physical activity and also by the psychological status. Recently, base BP (BP0: minimum and stable BP during sleep) has been reported to correlate with organ damage in hypertensives. However, little is known about the implications of BP0. We examined how BP0 is associated with BP, heart rate variability and healthrelated quality of life (HRQOL) in healthy subjects. One hundred and thirty-five participants, composed of 88 male and 47 female (age: 21-33 years) underwent a 24-h ambulatory BP monitoring (ABPM). Multiple linear regression analysis showed that SBP0 correlated with gender (Po0.01), night time LF/HF (Po0.04) and the scores of body pain (Po0.04). In conclusion, SBP0 correlated with BP, LF/HF and the scores of body pain (HRQOL). SBP0 may be a useful indicator for assessing 24-h BP, sympathetic nervous functions and HRQOL in healthy subjects.

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Hypoalgesia in genetically hypertensive rats (SHR) is absent in rats with experimental hypertension.

Cited by 110 publications

References 16 publications

Maternal family history of hypertension attenuates neonatal pain response

Maternal family history of hypertension attenuates neonatal pain response

Decreased pain perception and risk for hypertension: Considering a common physiological mechanism

Relationship between base blood pressure during sleep and health-related quality of life in healthy adults

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