Hypoaldosteronism

Role of the Renin-Angiotensin-Aldosterone System in the Regulation of Plasma Potassium in Chronic Renal Disease

“…Five of the six hyperkalemic subjects included in this study were found to have selective hypoaldosteronism [23], which may well account for their elevated plasma potassium levels; in each case, aldosterone deficiency was noted during normal sodium intake as well asfollowing sodium depletion, and hyperkalemia was aggravated during the period of salt restriction. It has been shown that treatment with mineralocorticoids consistently leads to normalization of plasma potassium values in such patients [33,36,42].…”

Recurrent Hyperkalaemia due to Selective Aldosterone Deficiency: Correction by Angiotensin Infusion

“…That the symptomatology is caused by the electrolyte derangements has been shown by the prompt clinical improve--r 653 ment when these are corrected and by the rapid return of symptoms when similar electrolyte disturbances are induced acutely (Hudson et al, 1957). That the disordered electrolyte pattern is due primarily to the deficiency of aldosterone is shown by the beneficial response to treatment with this corticosteroid (Hokfelt and Skanse, 1960;Jacobs and Posner, 1964) or other sodium retaining corticosteroids.…”

“…The association of acquired aldosterone deficiency with normal cortisol levels was first reported by Hudson et al (1957). The syndrome seems to be rare since only 21 further cases have been recorded (Skanse and Hokfelt, 1958;Hill et al, 1959;Lambrew et al, 1961;Rick et al, 1962;Posner and Jacobs, 1964;Wilson and Goetz, 1964;Gerstein et al, 1968;Vagnucci, 1969;McGiff et al, 1970;Vagnucci, 1970;Ferrara et al, 1970;Perez et al, 1972;Schambelan et al, 1972;Mellinger et al, 1972;Weidman et al, 1972;Brown et al, 1972a).…”

Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate.

“…Gordon's syndrome is unique in that patients have a consistently normal GFR. While patients with conditions associated with a primary disturbance of aldosterone secretion (Addison's disease, isolated hypoaldosteronism 48 ) or action (pseudohypoaldosteronism 31 ) have potentially normal GFRs, the sodium wasting and subsequent volume contraction markedly reduce GFR. This reduced GFR contributes to the hyperkalemia.…”