Hypoalbuminemia Predicts Poor Pregnancy Outcome among Cases of HELLP Syndrome in Nigeria

Amadi, Collins; Amadi, Bright

doi:10.52403/ijhsr.20211130

Cited by 1 publication

(2 citation statements)

References 15 publications

(38 reference statements)

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“…The COVID-19 disease outcome was categorized as discharged home, intensive care unit transfer/treatment care, and mortality. Serum albumin status was defined as normal albumin status (35-52 g/L) and hypoalbuminemia (<35 g/L) [13]. Hypoalbuminemia was further categorized as clinically significant (<25 g/L) or clinically insignificant (25-34 g/L) as previously documented [13].…”

Section: Data Definitions and Stratificationsmentioning

confidence: 99%

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Correlation of Plasma Albumin Status with Markers of Hepato-biliary Dysfunction and Systemic Inflammation Among COVID-19 Patients

Amadi¹,

Lawson²,

Amadi³

et al. 2022

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Background: Several studies have reported profound altered serum albumin level status among patients with COVID-19 disease. Hence, the current study aimed to evaluate the plasma albumin status levels and to establish the relationship between serum albumin level status and markers of hepato-biliary dysfunction and systemic inflammation among COVID-19 patients of African origin. Methods: This was a retrospective study of pre-treatment data obtained from patients with confirmed real-time reverse transcription-polymerase chain reaction COVID-19 disease in Eleme COVID-19 treatment center, Port Harcourt, Southern Nigeria. Data were obtained from each patients' case notes, medical review charts, nurses' vital signs/medication charts, laboratory records, and archived data from the electronic medical records using trained research assistants at the treatment center. The data extraction was done using validated data collection templates. Data analysis was done using standard protocols. Results: Among the 473 studied cases, 112 (23.7%) had normal plasma albumin status while 361 (76.3%) had low plasma albumin status. Among the low plasma albumin status subgroups, 57.6% and 42.4% had clinically insignificant and clinically significant low plasma albumin status levels, respectively. No difference was observed in the mean plasma levels/activities of all the markers of hepato-biliary dysfunctions between the subjects with normal and low albumin status levels and also between the clinically insignificant and clinically significant low plasma albumin status subgroups (p>0.05). However, a statistically significant difference was observed in the mean plasma levels of all the systemic inflammatory markers between the subjects with normal and low albumin status levels as well as between the clinically insignificant and clinically significant low plasma albumin status subgroups (p<0.05). Furthermore, no statistically significant relationship existed between the plasma albumin status levels and all the markers of hepato-biliary dysfunctions (p>0.05). However, significant inverse relationships existed between plasma albumin status levels and all the systemic inflammatory markers/indices (p<0.05). Conclusion: The present study indicates that low plasma albumin level status is common among COVID-19 patients and correlates significantly with systemic inflammation. Since COVID-19 is invariably associated with systemic inflammation, albumin may have therapeutic value in COVID-19 management. However, further studies are highly recommended.

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Section: Data Definitions and Stratificationsmentioning

confidence: 99%

“…Serum albumin status was defined as normal albumin status (35-52 g/L) and hypoalbuminemia (<35 g/L) [13]. Hypoalbuminemia was further categorized as clinically significant (<25 g/L) or clinically insignificant (25-34 g/L) as previously documented [13].…”

Section: Data Definitions and Stratificationsmentioning

confidence: 99%