Hypoalbuminemia Predicts Acute Stroke Mortality: Paul Coverdell Georgia Stroke Registry

Famakin, Bolanle M.; Weiss, Paul S.; Hertzberg, Vicki; McClellan, William; Presley, Rodney; Krompf, Kerrie; Karp, Herbert R.; Frankel, Michael

doi:10.1016/j.jstrokecerebrovasdis.2009.01.015

Cited by 47 publications

(36 citation statements)

References 39 publications

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“…This showed that hypoalbuminemia was significantly associated with in-hospital mortality which is similar to the study by Famakin et al (2010) 13 . Likewise, low level of serum albumin and poor outcome patients of stroke is similar in two studies as well.…”

Section: Discussionsupporting

confidence: 88%

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Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

Kirtania¹,

Khatun

Chowdhury³

et al. 2018

Bangladesh J Med Biochem

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Albumin is a non-glycosylated plasma protein synthesized primarily in the liver. It is a protein involved in the transport of small molecules in the blood and plays a key role in restricting fluid leakage from the vasculature into the tissue. Elevated level of serum albumin is related to haemoconcentration and reduced level is associated with malnutrition and chronic inflammatory diseases representing a negative acute phase protein. This cross sectional study was done to determine the association between admission serum albumin levels and short-term outcome following acute stroke. Consecutive first-ever acute stroke patients were enrolled between January 2016 and December 2016 at DMCH. On admission serum albumin were measured. Patients were then followed up for 10 days and outcome measure at the end of the study were 10- day mortality. Relationship between serum albumin and stroke outcome was determined. A total of 100 stroke cases were thus included in the study comprising 66 males and 34 females. The mean age of patients was 69.2±12.2 years. Of total, 74% patients were of ischemic stroke and 26% were of hemorrhagic stroke. Among them 22 patients expired in the hospitalization period within 10 days and remaining 78 patients were discharged. The mean serum level of albumin was 2.90±0.57 g/dl in the expired group and 3.79±0.51 g/dl in the discharged group. It may be concluded that low admission serum albumin may be significantly associated with poor outcome.Bangladesh J Med Biochem 2016; 9(1): 27-30

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Section: Discussionsupporting

confidence: 88%

“…In a recent study by Famakin et al (2010) 13 , 1477 patient admitted cases with acute stroke were evaluated. In-patient hospital death were 10%.…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

Kirtania¹,

Khatun

Chowdhury³

et al. 2018

Bangladesh J Med Biochem

View full text Add to dashboard Cite

show abstract

“…10 Famkin and et al in a study showed that Hypoalbuminemia is an independent risk factor predictor of mortality from ischemic stroke. 11 This study showed that there wasn't any significant relation between mortality from stoke and using albumin. Babu MS and et al in a study showed that higher rate of serum albumin in ischemia stroke decrease from bad prognosis of disease.…”

Section: Discussionmentioning

confidence: 77%

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

Abbasi

Fattahzadeh-Ardalani

Safarnejad

et al. 2016

Int J Basic Clin Pharmacol

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“…There commonly existed the phenomenon that serum albumin concentration was acutely decreased after major surgery or severe trauma clinically [1][2][3] , as the most important ingredient to maintain plasma colloid osmotic pressure, albumin could not only regulate dynamic balance of water between tissues and vessels, but also had such important effects as antioxidation, transporting hemoglobin, hormones and fatty acids, etc, the degree of hypoproteinemia was positively correlated with the patients' complications and mortality [12][13][14] . How to correct hypoproteinemia?…”

Section: ■ Discussionmentioning

confidence: 99%

Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits

Cen

et al. 2017

Acta Cir. Bras.

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Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits 1 3-Experimental SurgeryActa Cir Bras. 2017;32(2):108-115 AbstractPurpose: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. Methods: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate. Results: Compared with the saline group, the albumin group and the Syn group exhibited significantly increased serum albumin concentrations 48h after surgery (P<0.05). The albumin leakage rate was the most obvious in the albumin group, followed by the saline group, while that in the Syn group was the minimal, and there existed significant differences among these groups (P<0.05). Conclusion:Simple administration of albumin in the early stage after major abdominal surgery could increase the albumin leakage, while the synergization of albumin and hydroxyethyl starch could reduce the albumin leakage.

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Hypoalbuminemia Predicts Acute Stroke Mortality: Paul Coverdell Georgia Stroke Registry

Cited by 47 publications

References 39 publications

Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

Serum Albumin Level and Short-Term Outcome Following Stroke in Hospital Admitted Patients

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits

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