Hypoalbuminaemia is an Independent Predictor of Poor Outcome in Metastatic Ewing's Sarcoma Family of Tumours: A Single Institutional Experience of 150 Cases Treated with Uniform Chemotherapy Protocol

Biswas, Bivas; Rastogi, Sameer; Khan, Shah Alam; Shukla, Nootan Kumar; Deo, S.V.S.; Agarwala, Sandeep; Sharma, Daya Nand; Thulkar, Sanjay; Vishnubhatla, Sreenivas; Pathania, Subha; Bakhshi, Sameer

doi:10.1016/j.clon.2014.05.006

Cited by 33 publications

(35 citation statements)

References 22 publications

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“…Impaired estimated glomerular filtration rate was found to be a significant predictor for bladder cancer recurrence and progression and elevated preoperative serum creatinine was associated with worse cancer‐specific survival . Hypoalbuminaemia was found to be an independent predictor of poor outcome in metastatic Ewing's sarcoma, in patients with malignant pleural mesothelioma and non‐small lung cancer . However, underlying mechanisms for this association in cancer patients have not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Growing evidence emerged that low serum albumin levels and impaired kidney function as reflected by elevated serum creatinine are associated with decreased survival in cancer patients, though the exact mechanism remains still unknown …”

mentioning

confidence: 99%

“…[6][7][8][9][10] Growing evidence emerged that low serum albumin levels and impaired kidney function as reflected by elevated serum creatinine are associated with de-creased survival in cancer patients, though the exact mechanism remains still unknown. [11][12][13][14][15][16][17][18][19][20][21][22] The impact of serum creatinine and albumin on risk of mortality and survival in patients with STS has not yet been investigated. We set up a retrospective cohort study to analyze the association of serum creatinine and albumin with overall and disease-specific survival in patients with liposarcoma.…”

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confidence: 99%

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Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma

Panotopoulos

Posch

Funovics

et al. 2015

Journal Orthopaedic Research

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Low serum albumin levels and impaired kidney function have been associated with decreased survival in patients with a variety of cancer types. In a retrospective cohort study, we analyzed 84 patients with liposarcoma treated at from May 1994 to October 2011. Uni-and multivariable Cox proportional hazard models and competing risk analyses were performed to evaluate the association between putative biomarkers with disease-specific and overall survival. The median age of the study population was 51.7 (range 19.6-83.8) years. In multivariable analysis adjusted for AJCC tumor stage, serum creatinine was highly associated with diseasespecific survival (Subdistribution Hazard ratio (SHR) per 1 mg/dl increase ¼ 2.94; 95%CI 1.39-6.23; p ¼ 0.005). High albumin was associated with improved overall and disease-specific survival (Hazard Ratio (HR) per 10 units increase ¼ 0.50; 95%CI 0.26-0.95; p ¼ 0.033 and SHR ¼ 0.64; 95%CI 0.42-1.00; p ¼ 0.049). The serum albumin-creatinine-ratio emerged to be associated with both overall and disease-specific survival after adjusting for AJCC tumor stage (HR ¼ 0.95; 95%CI 0.92-0.99; p ¼ 0.011 and SHR ¼ 0.96; 95%CI 0.93-0.99; p ¼ 0.08). Our study provides evidence for a tumor-stage-independent association between higher creatinine and lower albumin with worse disease-specific survival. Low albumin and a high albumin-creatinine-ratio independently predict poor overall survival. Our work identified novel prognostic biomarkers for prognosis of patients with liposarcoma. ß

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma

Panotopoulos

Posch

Funovics

et al. 2015

Journal Orthopaedic Research

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“…Multi-agent chemotherapy has improved ES outcome, but most patients still recur and die [2-6]. Transformative therapy is therefore needed for ES.…”

Section: Introductionmentioning

confidence: 99%

Combining Tumor-Selective Bacterial Therapy with <b><i>Salmonella typhimurium</i></b> A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing’s Sarcoma in a Patient-Derived Orthotopic Xenograft Model

Miyake

Kiyuna

et al. 2018

Chemotherapy

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Background: Ewing’s sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics. Objectives: The aim of this study was to investigate the efficacy of tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model. Methods: The ES PDOX models were previously established in the right chest wall. The ES PDOX models were randomized into 5 groups when the tumor volume reached 80 mm³: G1: untreated control; G2: doxorubicin; G3: S. typhimurium A1-R; G4: o-rMETase; G5: S. typhimurium A1-R combined with o-rMETase. All mice were sacrificed on day 15. Body weight and tumor volume were assessed twice a week. Results: S. typhimurium A1-R and o-rMETase respectively suppressed tumor growth as monotherapies (p = 0.050 and p = 0.032). S. typhimurium A1-R combined with o-rMETase regressed tumor growth significantly compared to untreated group on day 15 (p < 0.032). S. typhimurium A1-R combined with o-rMETase group was significantly more effective than S. typhimurium A1-R or o-rMETase monotherapy (p = 0.032, p = 0.032). Conclusions: The present results suggest that the combination of S. typhimurium A1-R and o-rMETase has promise to be a transformative therapy for ES.

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“…Treatment generally consists of chemotherapy followed by surgery and/or radiotherapy. This multimodal approach drastically improved survival, from a 10‐year overall survival of approximately 10% up to 55% to 65% in patients with localized disease and 20% to 35% for patients with metastatic disease . During the last few decades local treatment has changed from routinely amputation to limb‐salvage, in which preservation of a functioning limb is at the essence of achieving clear margins …”

Section: Introductionmentioning

confidence: 99%

Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma

Bosma

Driel

Hogendoorn

et al. 2018

Journal of Surgical Oncology

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Ewing sarcoma (ES), an aggressive bone and soft‐tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra‐operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence‐guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra‐operatively, improving complete resection and therefore survival. This review evaluates potential ES‐specific proteins from the literature as targets for NIR FGS.

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Hypoalbuminaemia is an Independent Predictor of Poor Outcome in Metastatic Ewing's Sarcoma Family of Tumours: A Single Institutional Experience of 150 Cases Treated with Uniform Chemotherapy Protocol

Cited by 33 publications

References 22 publications

Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma

Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma

Combining Tumor-Selective Bacterial Therapy with <b><i>Salmonella typhimurium</i></b> A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing’s Sarcoma in a Patient-Derived Orthotopic Xenograft Model

Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma

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