Hypoadiponectinemia in Patients with Cerebral Infarction: Comparison with Other Atherosclerotic Disorders

The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

“…Moreover, no difference was noted in the serum adiponectin level between patients experiencing cerebral infarction and those with other atherosclerotic disorders (such as arteriosclerosis obliterans or ischemic heart disease) [44]. During the acute phase of cerebral infarction, ischemic stroke patients, display significantly decreased adiponectin levels upon admission compared to control subjects, but these levels in ischemic stroke patients subsequently recover to basal levels [44,45]. The association between adiponectin gene polymorphisms and ischemic stroke risk has also been examined.…”

“…The adiponectin levels change significantly in ischemic patients. Compared with controls, ischemic patients display significantly reduced serum adiponectin levels [44]. Moreover, no difference was noted in the serum adiponectin level between patients experiencing cerebral infarction and those with other atherosclerotic disorders (such as arteriosclerosis obliterans or ischemic heart disease) [44].…”

Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects

“…have a reduction in serum adiponectin levels [19]. The elevated circulatory RBP4 increases insulin resistance by inhibiting insulin signaling in muscular tissues and increasing hepatic glucose output [6,20]. Persistent insulin resistance may develop arteriosclerotic disorders, including ischemic heart disease, cerebrovascular disease and peripheral arterial disease (PAD) [21][22][23].…”

“…Exercise load could stimulate synthesis and/or release of RBP4 in the subjects without nephropathy. RBP4 is synthesized in skeletal muscles and white adipose tissues as well as in hepatocytes [1,20]. Kahn et al [9] reported that RBP4 mRNA was verified in rat skeletal muscles.…”

The Role of Serum Adiponectin Levels on Ischemic Stroke

“…It indicates anti-atherosclerotic property by blocking the effects of inflammation mediators that cause atherogenesis by cumulating on damaged blood vessel wall 8 . Adiponectin is a protein with anti-inflammatory and anti-atherogenic properties 9 . Inflammatory processes play a fundamental role in atherosclerotic cerebrovascular disease and stroke, which is the second leading cause of death worldwide and a major cause of long-term disability 10 .…”