Hypo-Agamma-Globulin�mie bei einem Fall von Amyloidose

Hypogammaglobulinaemia and Tuberculosis

“…In addition, abnormal enlargement of lymph nodes, liver, and spleen, separately or together, have been reported in some cases of the acquired deficiency only (Rohn et al, 1955;Good and Mazzitello, 1956;Citron, 1957); and, occasionally, a thymoma has been discovered (Good and Varco, 1955;Martin et al, 1956;MacLean et al, 1956;Ramos, 1956), removal of which did not alter the serum y-globulin level in one patient (MacLean et al, 1956). Such abnormalities were not present in my patient, but they have been found associated with granuloma or tumour involvement of the reticulo-endothelial system in some patientssarcoidosis (Zinnieman et al, 1954), malignant lymphoma (Arends et al, 1954), chronic lymphatic leukaemia (Prasad and Koza, 1954;Jim and Reinhard, 1956), as well as generalized amyloidosis (Gras et al, 1954)-and it may well be that such involvement directly impairs plasma-cell function and therefore antibody formation. It is probable that acquired hypogammaglobulinaemia is more commonly due to immaturity of plasma cells, as instanced by Citron (1957), and this may be genetically determined.…”

Systemic amyloidosis in a patient with hypogammaglobulinaemia

“…The occurrence of amyloidosis in patients with hypogammaglobulinaemia is rare and the pathogenesis incompletely known. Continuous chronic infection functioning as a trigger of the deposition of amyloid in the tissues could be an important aetiological factor in the majority of cases : all previously reported patients suffered from recurrent pneumonias and most had bronchiectasis [2][3][4][5][6][8][9][10]. In our patient, amyloidosis developed in association with an inadequate treatment of hypogammaglobulinaemia.…”

“…Keywords : amyloidosis, arthritis, hypogammaglobulinaemia. literature [2][3][4][5][6][7][8][9][10][11][12]. We describe here a patient with hypogammaglobulinaemia who developed nephrotic syndrome due to systemic amyloidosis in association with an inadequate dose of the gamma-globulin substitution therapy.…”

Primary `acquired' hypogammaglobulinaemia and amyloidosis

“…In this context the development of amyloidosis in a patient with primary 'acquired' hypogammaglobulinaemia is of relevance. Only five other fully documented reports of this association have been found in the literature (Gras, Latorre, and Gamissans, 1954;Teilum, 1964a;Clinicopathological Conference, 1965;Forssman and Herner, 1964;Conn and Quintiliani, 1966). The present case was reported previously before the diagnosis of amyloidosis was made (Cook and Melrose, 1958).…”