Hypno-Sedative Activity of Gymnema sylvestre Extract in Sodium Barbiturate - Induced Hypnosis in Rattus novergicus

James, Omale; Awam, Menegbe Nasara; Eleojo, Ojogbane

doi:10.11648/j.ab.20140205.11

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Hydrogen peroxide (H2O2) is found to be very hemolytic on red blood cells. This predicts the oxidative property of H2O2 against cell membrane and liberation of haemoglobin from the cells (James et al, 2014).…”

Section: Anti-haemolytic Activity On 2% Hrbc Suspensionmentioning

confidence: 98%

Phytochemical Screening and Study of Anti-Microbial, Anti-Haemolytic, Anti-Fungal and Anti-Oxidant Activities of Ethanol Extract of Panicum Sumatrense Leaves

N. A. Dogar,

M. Ghous,

A. Hanif

et al. 2023

PJS

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Little millets (Panicum Sumatrense) are of immense importance both medically and economically. Scientifically proven that the grains of little millets are nutritionally well. In the present research work, the less explored, underutilized, nutrient-rich and easily available Panicum sumatrense leaves were analysed for their phytochemical constituents and anti-oxidant or anti-haemolytic activity. The ethanolic extract of the little millet was examined to proximate, phytochemical determinations and anti-oxidant, anti–haemolytic, anti-bacterial and anti-fungal activity. It was found that the given sample contains important Phytochemicals. The extract prepared using leaves of Panicum sumatrense was evaluated for their antioxidant activity, anti-haemolytic activity using UV-Vis spectrophotometer. The antibacterial and antifungal activity tests were performed using the Agar well diffusion method. Anti-bacterial activity of ethyl alcohol extract and n-hexane extract was higher for Escherichia coli and In Staphylococcus aureus extract was slightly low effective. Anti-fungal activity of ethanolic and n-hexane extract was not satisfactory. The leaves extract showed that both anti-oxidant, anti-hemolytic and anti-bacterial activity increased with increasing concentration. Thus, the result revealed the anti-oxidant anti-haemolytic and anti-bacterial activity of the underutilized leaves of Panicum sumatrense.

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Section: Anti-haemolytic Activity On 2% Hrbc Suspensionmentioning

confidence: 98%

Phytochemical Screening and Study of Anti-Microbial, Anti-Haemolytic, Anti-Fungal and Anti-Oxidant Activities of Ethanol Extract of Panicum Sumatrense Leaves

N. A. Dogar,

M. Ghous,

A. Hanif

et al. 2023

PJS

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“…Anti-hemolytic activity assessment was performed as previously published [32]. Briefly, the same steps were performed as in the hemolysis assay except that H 2 O 2 was added to induce hemolysis.…”

Section: Assay Of Hemolysis and Anti-hemolytic Activitymentioning

confidence: 99%

Determination of Medicago orbicularis Antioxidant, Antihemolytic, and Anti-Cancerous Activities and Its Augmentation of Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells

Shaito,

Omairi,

Al-Thani

et al. 2024

Plants

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The anti-lung cancer properties of the plant Medicago orbicularis have not been explored yet. Therefore, we identified its phytochemical composition and investigated the antioxidant, anti-hemolytic, and anti-cancerous properties of extracts of this plant in A549 human lung adenocarcinoma cells. The results show that all parts of M. orbicularis (stems, leaves, and fruits) exhibit remarkable hemolytic activities and modest antioxidant capacity. In addition, all extracts showed a dose-dependent anti-cancerous cytotoxic activity against A549 cells, with fruit extracts being the most potent. This cytotoxic effect could be related, at least partly, to the induction of apoptosis, where M. orbicularis fruit extracts reduced the ratio of anti-apoptotic BCL-2/pro-apoptotic BAX, thereby promoting cellular death. Furthermore, the use of M. orbicularis, in combination with a conventional chemotherapeutic agent, cisplatin, was assessed. Indeed, the combination of cisplatin and M. orbicularis fruit extracts was more cytotoxic and induced more aggregation of A549 cells than either treatment alone. GC-MS analysis and total polyphenol and flavonoid content determination indicated that M. orbicularis is rich in compounds that have anti-cancerous effects. We propose M. orbicularis as a potential source of anti-cancerous agents to manage the progression of lung cancer and its resistance to therapy.

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<em>Medicago orbicularis</em> Has Antioxidant, Antihemolytic, and Anti-cancerous Activities and Augments Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells

Shaito,

Omairi,

Al-Thani

et al. 2023

Preprint

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Cancer is second leading cause of death, worldwide. Lung cancer is the leading cause of cancer-related mortality. Plant-based therapeutics and herbal medicine have played a vital role in the development of several anti-cancerous agents, and has been used to reduce the severe side effects of chemotherapy as well. Since the anti-lung cancer properties of the plant Medicago. orbicularis are not explored yet, we identified its phytochemical composition and investigated the anti-oxidant, anti-hemolytic, and anti-cancerous properties of extracts of this plant in A549 human lung adenocarcinoma cells. Results show that all parts of M. orbicularis (stems, leaves, and fruits) exhibit remarkable anti-oxidant and hemolytic activities. In addition, all extracts showed a dose-dependent anti-cancerous cytotoxic activity against A549 cells; with fruit extracts being the most potent. This cytotoxic effect could be related, at least partly, to the induction of apoptosis, where M. orbicularis fruit extracts activated Caspase-3 and PARPP-1, and reduced the ratio of anti-apoptotic BCL-2/ pro-apoptotic BAX, thereby promoting cellular death. Furthermore, the use of M. orbicularis, in combination with a conventional chemotherapeutic agent, cisplatin, was assessed. Indeed, combination of cisplatin and M. orbicularis fruit extracts was more cytotoxic and induced more aggregation of A549 cells than either treatment alone. GC-MS analysis and total polyphenol and flavonoid content determination indicated that M. orbicularis is rich in compounds that have anti-cancerous effects. M. orbicularis may be a potential source of anti-cancerous agents to manage progression of lung cancer and its resistance to therapy.

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Hypno-Sedative Activity of Gymnema sylvestre Extract in Sodium Barbiturate - Induced Hypnosis in Rattus novergicus

Cited by 3 publications

References 15 publications

Phytochemical Screening and Study of Anti-Microbial, Anti-Haemolytic, Anti-Fungal and Anti-Oxidant Activities of Ethanol Extract of Panicum Sumatrense Leaves

Phytochemical Screening and Study of Anti-Microbial, Anti-Haemolytic, Anti-Fungal and Anti-Oxidant Activities of Ethanol Extract of Panicum Sumatrense Leaves

Determination of Medicago orbicularis Antioxidant, Antihemolytic, and Anti-Cancerous Activities and Its Augmentation of Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells

<em>Medicago orbicularis</em> Has Antioxidant, Antihemolytic, and Anti-cancerous Activities and Augments Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells

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