Hyphenated techniques of thermal analysis for dibenz[b,f][1,4]oxazepine

Xue, Tian; Cui, Qingzhong; Han, Yong-he; Wang, Shan; Mao, Yong-Yang

doi:10.1039/c5ay03368c

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The encoded protein is a transmembrane transport protein that is known to serve as a prognostic biomarker for cancers such as renal cell carcinoma and lung adenocarcinoma (Arroyo Varela et al, 2019;Kang et al, 2020). This gene has been shown to be differentially methylated in colon cancer (Xue et al, 2018). WFIKKN2 17 20 5.24E-11 The encoded protein is a protease that inhibits the biological activity of myostatin with potential as a biomarker for risk of type 2 diabetes (Ngo et al, 2021).…”

Section: Genes Are Differentially Methylated After Hctmentioning

confidence: 99%

DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients

Mohanraj

Wolf

Silvey

et al. 2022

Biological Research For Nursing

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Background Blood cancers may be potentially cured with hematopoietic stem cell transplantation (HCT); however, standard pre-assessments for transplant eligibility do not capture all contributing factors for transplant outcomes. Epigenetic biomarkers predict outcomes in various diseases. This pilot study aims to explore epigenetic changes (epigenetic age and differentially methylated genes) in patients before and after autologous HCT, that can serve as potential biomarkers to better predict HCT outcomes. Methods This study used a prospective longitudinal study design to compare genome wide DNA methylation changes in 36 autologous HCT eligible patients recruited from the Cellular Immunotherapies and Transplant clinic at a designated National Cancer Center. Results Genome-wide DNA methylation, measured by the Illumina Infinium Human Methylation 850K BeadChip, showed a significant difference in DNA methylation patterns post-HCT compared to pre-HCT. Compared to baseline levels of DNA methylation pre-HCT, 3358 CpG sites were hypo-methylated and 3687 were hyper-methylated. Identified differentially methylated positions overlapped with genes involved in hematopoiesis, blood cancers, inflammation and immune responses. Enrichment analyses showed significant alterations in biological processes such as immune response and cell structure organization, however no significant pathways were noted. Though participants had an advanced epigenetic age compared to chronologic age before and after HCT, both epigenetic age and accelerated age decreased post-HCT. Conclusion Epigenetic changes, both in epigenetic age and differentially methylated genes were observed in autologous HCT recipients, and should be explored as biomarkers to predict transplant outcomes after autologous HCT in larger, longitudinal studies.

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Section: Genes Are Differentially Methylated After Hctmentioning

confidence: 99%

DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients

Mohanraj

Wolf

Silvey

et al. 2022

Biological Research For Nursing

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“…Then, as the next generation of RCAs, CS became the most widely used RCA in the world, which is a 10 times more potent lacrimator than CN and less toxic [1,2]. As a third-generation riot control agent, CR has a large extensive safe range than CN and CS [3]. In recent years, OC pepper spray has become popular with law enforcement agencies and replaced CN and CS for civilian use [4].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of trace level riot control agents in environmental water by solid‐phase microextraction and gas chromatography coupled with a flame ionization detector

Hao¹,

Wang²,

Zhao³

et al. 2022

J of Separation Science

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In this paper, a direct immersion solid‐phase microextraction procedure for the simultaneous analyses of four primary riot control agents: 2‐chloroacetophenone, o‐chlorobenzylidene malonitrile, dibenz(b,f)‐1,4‐oxazepine, and oleoresin capsicum at μg/L concentration from environmental water was developed. Several parameters that influence the extraction effectiveness were investigated, including fiber type, extraction temperature, extraction time, starring rate, and salinity. Under the recommended conditions, the optimized method had reasonable linearity and accuracy. The average recovery of this method ranged from 84 to 108.1%. The limit of detection for all the analytes ranged from 0.2 to 3 μg/L and the limit of quantification ranged from 1 to 10 μg/L, respectively. A relative standard deviation from 3.0 to 4.3% can be achieved depending on the compounds. The procedure was applied to analyze all the four riot control agents simultaneously in several environmental samples.

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Hyphenated techniques of thermal analysis for dibenz[b,f][1,4]oxazepine

Cited by 2 publications

References 26 publications

DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients

DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients

Simultaneous determination of trace level riot control agents in environmental water by solid‐phase microextraction and gas chromatography coupled with a flame ionization detector

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