Hyphenated Techniques for Analysis of Complex Organic Mixtures

Wilkins, Charles L.

doi:10.1126/science.6353577

Cited by 55 publications

(15 citation statements)

References 29 publications

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“…If expensive high-performance IR and mass spectrometers are required for success, it is not likely that the method will be widely adopted for routine mixture analysis. For example, a review that appeared late in 1982 (20) discussed GC/IR/MS analysis studies using very expensive high-performance double focusing (12) and Fourier transform mass spectrometers (19) in combination with top-of-the-line FT-IR spectrometers. Such systems involved use of close to half a million dollars' worth of equipment.…”

Section: Instrumentation For Gc/ir/msmentioning

confidence: 99%

Linked Gas Chromatography Infrared Mass Spectrometry

Wilkins¹

1987

Anal. Chem.

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Section: Instrumentation For Gc/ir/msmentioning

confidence: 99%

Linked Gas Chromatography Infrared Mass Spectrometry

Wilkins¹

1987

Anal. Chem.

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“…In particular, the combination of a gas chromatograph with the mass spectrometer is eminently suited for the analysis of complex organic mixtures [2][3][4] . The gas chromatograph (GC) reduces/eliminates the complexity of the analyte, expected to be encountered in the field environment.…”

Section: Introductionmentioning

confidence: 99%

<title>Miniature mass spectrometer for chemical sensing in homeland defense applications</title>

Sinha

Houseman

2003

SPIE Proceedings

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A Miniature Mass Spectrometer (MMS) with an array detector has been developed at the Jet Propulsion Laboratory (JPL). The spectrometer has a focal plane geometry, and an array detector that can measure the intensities of different masses simultaneously after their separation along the focal plane. In the past, the large mass, size and the lack of an array detector with high gain (such as an electron multiplier) did not allow the application of focal plane mass spectrometer to the measurement that required high sensitivity and portability. In the JPL developed-MMS, miniaturization has been accomplished by using rare earth magnet material and novelties in the design of the magnetic and electric sectors. A new ion detector was developed for the measurement of the intensities of different mass ions. The array detector is based on the conversion sequence of ions into electrons into photons and their final measurement by a photon array detector. MMS possesses high sensitivity, specificity, and fast response time and can be used as a universal chemical analyzer. It will find application in a variety of Home Defense tasks. MMS is presently being applied for the detection of propellants (hydrazine and its derivatives). The instrument will have a mass of 1-2 kg and consume a power of 2-4 W for operation Keywords: miniature mass spectrometer, array detector for ions, isotope measurement, microbore capillary column, and gas chromatograph.

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“…The hyphenated 63 technique GC-MS is widely used in forensic analysis and has become a "gold standard" in many fields of application. [64][65][66][67][68][69][70][71][72] Screening and confirmation of illicit drugs is often made by GC-MS, although there are alternatives 73 .…”

Section: Gc-msmentioning

confidence: 99%

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Carlsson¹

2016

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The application of different analytical techniques is fundamental in forensic drug analysis. In the wake of the occurrence of large numbers of new psychoactive substances possessing similar chemical structures as already known ones, focus has been placed on applied criteria for their univocal identification. These criteria vary, obviously, depending on the applied technique and analytical approach. However, when two or more substances are proven to have similar analytical properties, these criteria no longer apply, which imply that complementary techniques have to be used in their differentiation.This work describes the synthesis of some structural analogues to synthetic cannabinoids and cathinones based on the evolving patterns in the illicit drug market. Six synthetic cannabinoids and six synthetic cathinones were synthesized, that, at the time for this study, were not as yet found in drug seizures. Further, a selection of their spectroscopic data is compared to those of already existing analogues; mainly isomers and homologues. The applied techniques were mass spectrometry (MS), Fourier transformed infrared (FTIR, gas phase) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. In total, 59 different compounds were analyzed with the selected techniques.

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Hyphenated Techniques for Analysis of Complex Organic Mixtures

Cited by 55 publications

References 29 publications

Linked Gas Chromatography Infrared Mass Spectrometry

Linked Gas Chromatography Infrared Mass Spectrometry

<title>Miniature mass spectrometer for chemical sensing in homeland defense applications</title>

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

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