Hyphal‐associated protein expression is crucial for Candida albicans‐induced eicosanoid biosynthesis in immune cells
Jana Schimanski,
Mark S. Gresnigt,
Elena Brunner
et al.
Abstract:Candida albicans causes opportunistic infections ranging from mucosal mycoses to life‐threatening systemic infections in immunocompromised patients. During C. albicans infection, leukotrienes and prostaglandins are formed from arachidonic acid by 5‐lipoxygenase (5‐LOX) and cyclooxygenases, respectively to amplify inflammatory conditions, but also to initiate macrophage infiltration to achieve tissue homeostasis. Since less is known about the cellular mechanisms triggering such lipid mediator biosynthesis, we i… Show more
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