Hypervitaminosis a in the Dog

Maddock, Charlotte L.; Wolbach, S. B.; Maddock, Stephen

doi:10.1093/jn/39.1.117

Cited by 46 publications

(12 citation statements)

References 20 publications

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“…Histologically, eosinophilic cartilage which appeared in the growth plates was undergoing necrosis and some areae of the region were destroyed [2], whereas blood vessels invaded the growth plates from the epiphyseal side [11]. Clark [3] also observed such invading by blood vessels and illustrated that, in discontinuous plates, V-shaped cartilage remnants on the diaphysial side bridged the gap between the broken ends.…”

Section: Animalsmentioning

confidence: 99%

Local Disappearance of Epiphyseal Growth Plates in Rats with Hypervitaminosis A.

Kodaka

Takaki

Soeta

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. Epiphyseal growth plates of proximal tibiae in rats with high doses of vitamin A (V-A) were observed. Of 4 groups, each consisting of 5 rats, three groups were given V-A at doses, IU/100 g by body weight/day, of 50,000, 100,000, and 150,000, respectively. The other group rats were given no V-A (control). Rats were administered V-A for the 5 days from 4 weeks after birth and sacrificed at 12 weeks after birth. Three rats of the 150,000 IU group died during the period of observation. The decalcified sections were stained with hematoxylin-eosin or toluidine blue. In the ground sections, microradiography, backscattered electron imaging, and energy-dispersive Xray microanalysis were performed. These observations suggest that the local disappearance of epiphyseal growth plates under high doses of V-A goes in the order of the increased doses through the process of (1) calcified cartilage areae appearing in the resting cell zone, (2) some of the calcified areae extending in the growth plate towards the diaphysial side, (3) bone tissue replacing the calcified areae, and (4) the local disappearing of the growth plate. Such a local disappearance may be formed in the stressed proximal regions of tibiae. -KEY WORDS: calcified cartilage, epiphyseal growth plate, hypervitaminosis A, local disappearance, sulfur content.

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Section: Animalsmentioning

confidence: 99%

Local Disappearance of Epiphyseal Growth Plates in Rats with Hypervitaminosis A.

Kodaka

Takaki

Soeta

et al. 1998

The Journal of Veterinary Medical Science

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“…Animal studies support the notion that both vitamin A excess [31][32][33][34][35][36][37] and deficiency 32,34,38 have profound adverse effects on bone. In rats fed oral doses of retinyl esters at 25,000 -75,000 IU/d, the most characteristic lesion found was spontaneous bone fracture, 31,32,36 an outcome that occurred more consistently in young than in older rats.…”

Section: Animal Studies Case Reports and Studies Of Humans On Synthmentioning

confidence: 85%

Vitamin A: Is It a Risk Factor for Osteoporosis and Bone Fracture?

Ribaya-Mercado

Blumberg

2008

Nutrition Reviews

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Results from observational studies of the association between vitamin A intake or serum concentration and bone mineral density or fracture are mixed. The inconsistencies may be due, in part, to difficulties in obtaining an accurate assessment of vitamin A intake or status. Serum retinol is a poor measure of vitamin A status because it is subject to homeostatic control. Stable-isotope-dilution methodology gives a validated assessment of the total-body and liver vitamin A stores and is recommended in future studies on vitamin A status and osteoporosis. The potential for exacerbating an already serious public health problem with intakes of vitamin A currently considered safe indicates further research into this matter is warranted.

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“…Brandes .... Many studies have demonstrated that in growing and adult animal and human tissues, bone is one of the most important target sites of vitamin A action 17,18,20,[25][26][27][28] and that in a variety of experimental systems, embryogenesis of both eartilagenous and bony structures is altered by vitamin A. [29][30][31][32][33] Because of our interest in the effects of vitamin A on bone,34 our first studies made use of an osteogenic sarcoma which has shown persistence of osteoid tissue after multiple animal passages.…”

Section: Effect Of Vitamin a On Malignant Tissues Brandes Et Aps Dementioning

confidence: 99%