Hyperviscosity Syndrome in Arterial Hypertension and Hemorheological Effects of Antihypertensive Drugs

Шаманаев, А. Ю.; Алиев, О. И.; Анищенко, А. М.; Сидехменова, А. В.; Плотников, М. Б.

doi:10.15829/1560-4071-2016-4-97-102

Cited by 2 publications

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“…[ 5 6 ] Therefore, during the treatment and investigation of the action mechanisms of a new antihypertensive drug, special attention should be paid to assessment of the effect on blood rheology. [ 7 8 ]…”

Section: Introductionmentioning

confidence: 99%

Hemorheological effects of amlodipine in spontaneously hypertensive rats

et al. 2017

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OBJECTIVES:The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated.MATERIALS AND METHODS:SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured.RESULTS:The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%. Nevertheless, BV tended to increase. The administration of amlodipine had no effect on PV, plasma fibrinogen concentration, RBC aggregation, and RBC deformability, but hematocrit was higher (by 6%) than it was in control group.CONCLUSIONS:These results demonstrate that amlodipine has no positive hemorheological improvements when administered to SHRs.

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Section: Introductionmentioning

confidence: 99%

Hemorheological effects of amlodipine in spontaneously hypertensive rats

et al. 2017

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Effect of the combined administration of metoprolol and dihydroquercetin on the rheological properties of blood in spontaneously hypertensive rats (SHRs)

Сидехменова

Алиев

Анищенко

et al. 2021

Regional blood circulation and microcirculation

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Introduction. Hyperviscosity syndrome plays an important role in the pathogenesis of arterial hypertension and its complications associated with impaired microcirculation in target organs. Therefore, along with the use of antihypertensive drugs, it is important to pay attention to the correction of the hyperviscosity syndrome with means of hemorheological agents.The aim is to study the effect of metoprolol and its combined use with dihydroquercetin (DHQ) on the rheological parameters of blood in rats with spontaneous arterial hypertension.Materials and methods. The experiments were carried out on normotensive male Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). SHRs of the experimental groups received metoprolol (50 mg/kg) or metoprolol and DHQ (50 mg/kg each) daily intragastrically for 6 weeks in 1 % starch mucus; SHRs of the control group and normotensive rats received 1 % starch mucus according to the same scheme. Systemic blood pressure was registered in awake animals. Blood was sampled from the catheterized right common carotid artery. Blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation and deformability were studied.Results. Compared with the parameters in normotensive rats, SHRs showed significant increase of blood viscosity, hematocrit, erythrocyte aggregation, and decrease of erythrocyte deformability. The course administration of metoprolol induced to a further increase in blood viscosity at low shear rates (15–45 s–1); plasma viscosity, hematocrit and micro-rheological parameters in rats of this group did not significantly differ from those in the control. With the combined administration of metoprolol and DHQ, blood viscosity at shear rates of 300 and 450 s–1 and erythrocyte aggregation were significantly lower than in the control SHRs.Conclusions. The course administration of metoprolol increases the severity of the hyperviscosity syndrome in SHRs. The use of DHQ together with metoprolol partially eliminates adverse effects of the beta blocker on blood rheology parameters.

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Hyperviscosity Syndrome in Arterial Hypertension and Hemorheological Effects of Antihypertensive Drugs

Cited by 2 publications

References 10 publications

Hemorheological effects of amlodipine in spontaneously hypertensive rats

Hemorheological effects of amlodipine in spontaneously hypertensive rats

Effect of the combined administration of metoprolol and dihydroquercetin on the rheological properties of blood in spontaneously hypertensive rats (SHRs)

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