Hyperviscosity and Hypofunction of the Seminal Vesicles

Gonzales, Gustavo F.; Kortebani, G.; Mazzolli, Alicia B.

doi:10.3109/01485019308988370

Cited by 53 publications

(37 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This prevalence was considerably lower than that found by Gonzales et al [8,9], but considerably higher when compared with that found by Gopalkrishnan et al [27] WBCs and/or inflammatory alterations observed by ultrasound. Group C, subjects negative for the above situations.…”

Section: Discussioncontrasting

confidence: 51%

See 1 more Smart Citation

Human semen hyperviscosity: prevalence, pathogenesis and therapeutic aspects

Elia¹,

Delfino²,

Imbrogno³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

The aims of this study were (a) to determine the prevalence of subjects with semen hyperviscosity (SHV) in a large population of male partners of subfertile couples; (b) to identify any correlation between SHV and infections or inflammation of the genital tract; (c) to assess the effects of therapeutic approaches for treating SHV; and (d) to assess sperm kinetic parameters after successful treatment of SHV. A retrospective study of 1 833 male partners of subfertile couples was conducted. Next, clinical, seminal, bacteriological and ultrasound studies involving 52 subjects suffering from SHV were performed, and the SHV was classified as being mild (length of thread > 2 cm and ≤ 4 cm), moderate (> 4 cm and ≤ 6 cm) or severe (> 6 cm). The prevalence of SHV was observed in 26.2% (480) of the subjects, with 13.2% suffering from mild, 6.6% from moderate and 6.4% from severe SHV. Treatment was completely successful in only 27 subjects (52.0%), primarily in those who had mild basal SHV with a positive semen culture. In these subjects, progressive motility percentage, straight line velocity and linearity were significantly higher than pre-treatment levels. SHV is often found in subjects with subfertility. Pathogenesis was strictly related to infective/inflammatory factors in only 48.0% of cases; therefore, it is possible that biochemical, enzymatic or genetic factors have a role in this condition.

show abstract

Section: Discussioncontrasting

confidence: 51%

“…Gonzales et al [8,9] and Andrade-Rocha [10] showed reduced levels of fructose in SHV, and hypothesized inadequate functioning of the seminal vesicles as the explanation. Carpino and Siciliano [11] studied the possible correlation between SHV and protein secretion of the epididymis, vesicles and prostate.…”

Section: Introductionmentioning

confidence: 99%

Human semen hyperviscosity: prevalence, pathogenesis and therapeutic aspects

Elia¹,

Delfino²,

Imbrogno³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…Semen samples coagulation and liquefaction with their physiological characteristics are still not fully understood; however, the negative effects of hyperviscosity on semen parameters, above all motility, are known. As reported in literature, hyperviscosity is due to a "trapping effect" that prevents normal sperm progression through the female genital tract (9,(10)(11)(12). There is evidence of a correlation between hyperviscosity (SHV) and low levels of fructose in seminal plasma, due to an impaired function of the seminal vesicles (11).…”

Section: Introductionmentioning

confidence: 99%

Analysis of MYO-Inositol effect on spermatozoa motility, in hyper viscous ejaculates and in patients with grades II and III varicocele

Scarselli

Lobascio

Terribile

et al. 2016

Arch Ital Urol Androl

View full text Add to dashboard Cite

The goal of this study is to evaluate MYOInositol effects on spermatozoa motility, in patients’ ejaculates with severe varicocele or hyper viscosity. The study included normal viscosity ejaculate from 30 patients affected by varicocele and hyper viscosity ejaculate from 33 patients without any testicular pathologies. All selected samples showed sperm concentration > 2 million/ml and progressive motility < 32%. In both groups, the pellet obtained after centrifugation in buffered medium, was divided in two aliquots, both incubated for 15 minutes at 37°C: one with MYO-Inositol and the other one, as control, only in phosphate buffered saline (PBS). Afterwards, the sperm progressive motility was assessed using Computer Assisted Sperm Analysis (CASA system). Incubation with MYO-Inositol improved sperm progressive motility in high viscosity samples compared to control group (38.9% ± 3.0 vs 24.35% ± 2.41, respectively; p ≤ 0.0001). Conversely, no statistically significant difference was observed in total sperm progressive motility in varicocele samples compared with control group (22.7% ± 2.07 vs 26.7% ± 3.31, respectively; p = 0.085). The MYO-Inositol positive effect on spermatozoa motility may depend on the type of sperm damage: heavy structural and biochemical defects which typically affects patients with varicocele are not restored by Inositol. On the contrary, MYOInositol is able to improve sperm motility in semen samples with high viscosity, since those samples show no substantial structural sperm defects.

show abstract

“…Recently, we found that seminal hyperviscosity was related to hypofunction of the seminal vesicles [6] and suggested that the effect on male fertility is more than a simple mechanical effect.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, semen with high amounts of seminal-vesicular fluid had low-chromatin zinc and low stability of sperm chromatin [2]. Since seminal hyperviscosity is associated with low vesicular fluid and a relatively high "prostatic fluid" [6], then stability of sperm chromatin should be increased.…”

Section: G F Gonzales and A Stinchezmentioning

confidence: 99%