Hyperventilation Associated with Quetiapine

Shelton, Penny S.; Barnett, Faith L; Krick, Stacie E.

doi:10.1345/aph.19232

Cited by 20 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One case report of olanzapine-associated respiratory failure occurred in an elderly patient with chronic lung disease and the authors recommend careful observation of patients with chronic lung disease treated with olanzapine [79]. In the clinical trials of quetiapine, hyperventilation was reported to occur in <1/1000 patients treated and case reports have appeared in the literature [80]. Lithium, anticonvulsants, risperidone and ziprasidone do not appear to alter respiratory drive.…”

Section: Resultsmentioning

confidence: 99%

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities

McLaren

Marangell

2004

Ann Gen Hosp Psychiatry

View full text Add to dashboard Cite

Background: The pharmacological treatment of bipolar disorder has dramatically improved with multiple classes of agents being used as mood-stabilizers, including lithium, anticonvulsants, and atypical antipsychotics. However, the use of these medications is not without risk, particularly when a patient with bipolar disorder also has comorbid medical illness. As the physician who likely has the most contact with patients with bipolar disorder, psychiatrists must have a high index of suspicion for medical illness, as well as a basic knowledge of the risks associated with the use of medications in this patient population.

show abstract

Section: Resultsmentioning

confidence: 99%

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities

McLaren

Marangell

2004

Ann Gen Hosp Psychiatry

View full text Add to dashboard Cite

show abstract

“…Clinical practice and post-marketing studies show a good tolerability [14] . However, there is initial evidence from case reports and recent surveillance studies that quetiapine can cause a variety of respiratory problems ranging from hyperventilation to acute respiratory failure, even at normal doses [9,14] . After an overdose intubation is often needed [1,5,8,12] , although poisoning is rarely lethal and doses up to 24 g have been survived [1,4,10] .…”

Section: Introductionmentioning

confidence: 99%

Respiratory Dysfunction in Sleep Apnea Associated with Quetiapine

Freudenmann¹,

Süßmuth²,

Wolf³

et al. 2008

Pharmacopsychiatry

View full text Add to dashboard Cite

Quetiapine is an atypical antipsychotic with good tolerability, but has recently been associated with respiratory dysfunction. The aim of this work is to report on moderate to severe respiratory dysfunction after normal oral doses of quetiapine in two obese patients with sleep apnea syndrome (SAS). In the first case, acute respiratory failure and coma occurred after a single normal oral dose of quetiapine in combination with lorazepam (although even higher doses of lorazepam alone were tolerated) in a patient with previously unknown SAS. Intensive care treatment and mechanical ventilation led to full recovery. The second case was a patient with an operated obstructive SAS in which quetiapine was associated with nocturnal respiratory dysfunction and confusion. Respiratory function should be monitored when using quetiapine in patients with possible sleep apnea, particularly in obese patients and when given in combination with benzodiazepines.

show abstract

“…A side effect of this drug is hyperventilation and development of respiratory alkalosis. The acid-base findings in this case exclude quetiapine (choice A) as the correct answer (19,20).…”

mentioning

confidence: 62%

“…Nonmelanoma skin cancers are the most common ma- lignancies experienced by kidney transplant recipients, occurring 50 to 200 times more frequently than in the general population. Nonrandomized studies as well as retrospective analyses of randomized trials have suggested that nonmelanoma skin cancers may be less common in transplant recipients treated with sirolimus-based immunosuppression than in control groups (18,19). In a recent multicenter German trial, 44 patients with multiple skin keratoses and skin cancers were randomized either to remain on conventional immunosuppression or to convert to sirolimus (20).…”

Section: Transplantation Question 2amentioning

confidence: 99%

The 2010 Nephrology Quiz and Questionnaire

Glassock

Bleyer

Hricik

et al. 2011

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Presentation of the Nephrology Quiz and Questionnaire (NQQ) Transplantation Case 1: Donald E. HricikA 63-year-old woman with ESRD secondary to type 2 diabetes mellitus received a kidney transplant from a deceased donor 6 months ago. The donor was serologically positive for Epstein Barr-virus (EBV) and for cytomegalovirus (CMV) based on IgG titers, while the recipient was serologically negative for both EBV and CMV. The patient received induction antibody therapy with rabbit anti-thymocyte globulin (total dose ϳ 6 mg/kg) and maintenance therapy with tacrolimus, enteric-coated mycophenolate sodium, and glucocorticoids that were withdrawn per protocol after 7 days. At the time of transplantation, the following prophylactic agents were prescribed: trimethoprim-sulfamethoxazole (one single strength daily for life), co-trimazole troches (10 mg three times daily for 3 months), and valganciclovir (450 mg daily for 3 months

show abstract

Hyperventilation Associated with Quetiapine

Abstract: The development of hyperventilation and respiratory alkalosis was associated with the administration of quetiapine.

Cited by 20 publications

References 11 publications

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities

Respiratory Dysfunction in Sleep Apnea Associated with Quetiapine

The 2010 Nephrology Quiz and Questionnaire

Contact Info

Product

Resources

About