Hyperuricemia predicts adverse outcomes in patients with heart failure

Hamaguchi, Sanae; Furumoto, Tomoo; Tsuchihashi-Makaya, Miyuki; Goto, Kazutomo; Goto, Daisuke; Yokota, Takashi; Kinugawa, Shintaro; Yokoshiki, Hisashi; Takeshita, Akira; Tsutsui, Hiroyuki

doi:10.1016/j.ijcard.2010.05.002

Cited by 97 publications

(79 citation statements)

References 45 publications

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“…Elevated serum UA levels may be a result of increased production, reduced renal excretion, or of both situations. Many previous studies have confirmed the importance of hyperuricemia, an independent factor of poor prognosis in patients with hypertension, coronary artery disease, chronic heart failure and chronic kidney disease (CKD) [2][3][4][5]. Nevertheless, it has not completely explained the mechanism of the negative effects of hyperuricemia on the function of the heart muscle.…”

Section: Original Papersmentioning

confidence: 99%

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Gromadziński¹,

Januszko‐Giergielewicz

Pruszczyk

2015

Adv Clin Exp Med

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Background. It has been reported that elevated serum uric acid (UA) levels is an independent factor of poor prognosis in patients with chronic heart failure and chronic kidney disease (CKD). Objectives. In our study, we assessed the potential impact of hyperuricemia on left ventricular (LV) diastolic dysfunction (DD) in patient with CKD. Material and Methods. The study group consisted of 50 patients with CKD, stages 2-5. Standard echocardiography and tissue Doppler imaging (TDI) were performed. The levels of UA and N-terminal prohormone brain natriuretic peptide (NT-proBNP) were determined. Patients were divided into two groups according to the results of peak mitral annular early diastolic velocity (EmLV): group with LV diastolic dysfunction (EmLV < 8 cm/s) DD (+) and group with normal LV diastolic function DD (-), when EmLV ≥ 8 cm/s. Results. Patients DD (+) group, as compared to DD (-) patients were characterized by significantly higher serum UA levels [6.7 (4.4-14.3) mg/dL vs 5.8 (1.9-8.9) mg/dL, p = 0.004] respectively. The area under the receiver operating characteristic (ROC) curve was of serum UA levels for the detection of LV diastolic dysfunction was 0.734, 95% confidence interval (CI) 0.590-0.849, p = 0.001, whereas ROC derived UA value of > 6.0 mg/dL was characterized by a sensitivity of 76.9% and specificity of 62.5% for diagnosing LV diastolic dysfunction. The independent variable predicting LV diastolic dysfunction as measured by a multivariate logistic regression analysis was UA level > 6.0 mg/dL with odds ratio (OR) = 14.3 (95% CI 2.0-103.2), p = 0.006. Conclusions. Hyperuricemia is an independent predictive factor for LV diastolic dysfunction in patients with CKD (Adv Clin Exp Med 2015, 24, 1, 47-54).

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Section: Original Papersmentioning

confidence: 99%

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Gromadziński¹,

Januszko‐Giergielewicz

Pruszczyk

2015

Adv Clin Exp Med

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show abstract

“…9,10,14,15, 19 Briefly, eligible patients were those hospitalized with worsening HF as the primary cause of admission. The study hospitals were encouraged to register the patients as consecutively as possible.…”

Section: Patientsmentioning

confidence: 99%

Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure

Hamaguchi

Kinugawa

Tsuchihashi-Makaya

et al. 2012

Circ J

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“…12- 19 The purpose of the present study was to determine both the prevalence of low BMI in the JCARE-CARD database and whether it is independently associated with long-term outcomes, including mortality and rehospitalization because of worsening HF.…”

mentioning

confidence: 99%

Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

Hamaguchi

Tsuchihashi-Makaya

Kinugawa

et al. 2010

Circ J

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Hyperuricemia predicts adverse outcomes in patients with heart failure

Cited by 97 publications

References 45 publications

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Loop Diuretic Use at Discharge Is Associated With Adverse Outcomes in Hospitalized Patients With Heart Failure

Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -

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